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Environmental Pollutants and Epigenetics
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 Title & Authors
Environmental Pollutants and Epigenetics
Park, Sung-Kyun; Lee, Sun-Dong;
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Since Barker found associations between low birth weight and several chronic diseases later in life, the hypothesis of fetal origins of adult disease (aka, Barker Hypothesis) and epigenetics have been emerging as a new paradigm for geneenvironment interaction of chronic disease. Epigenetics is the study of heritable changes in gene silencing that occur without any change in DNA sequence. Gene expression can be regulated by several epigenetic mechanisms, including DNA methylation and histone modifications, which may be associated with chronic conditions, such as cancers, cardiovascular disease, and type-2 diabetes. One carbon metabolism which involves the transfer of a methyl group catalyzed by DNA methyltransferase is an important mechanism by which DNA methylation occurs in promoter regions and/or repetitive elements of the genome. Environmental factors may induce epigenetic modification through production of reactive oxygen species, alteration of methyltransferase activity, and/or interference with methyl donors. In this review, we introduce recent studies of epigenetic modification and environmental factors, such as heavy metals, environmental hormones, air pollution, diet and psychosocial stress. We also discuss epigenetic perspectives of early life environmental exposure and late life disease occurrence.
environment;epigenetics;DNA methylation;histone modification;one-carbon metabolism;
 Cited by
최근 보건의료분야에서 활발하게 연구되고 있는 "Epigenetics"란 무엇인가? -기본개념 및 기전을 중심으로-,이선동;박성균;고성규;신헌태;김명동;

대한예방한의학회지, 2010. vol.14. 2, pp.1-12
환경성 발암 기전에서 유전자-환경 상호작용의 역할,한소희;이경무;

한국환경보건학회지, 2010. vol.36. 1, pp.1-13 crossref(new window)
The Role of Gene-environment Interaction in Environmental Carcinogenesis, Korean Journal of Environmental Health Sciences, 2010, 36, 1, 1  crossref(new windwow)
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