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Occupational Exposure to Trichloroethylene and Non-hodgkin Lymphoma Risk
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 Title & Authors
Occupational Exposure to Trichloroethylene and Non-hodgkin Lymphoma Risk
Chun, Jae-Buhm; Han, So-Hee; Yoon, Hyung-Suk; Lee, Eun-Jung; Lee, Kyoung-Mu;
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Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies
Trichloroethylene;Non-hodgkin lymphoma;Occupational exposure;Cohort study;Case-control study;Immune response;Biomarker;
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