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Distribution of PFOA and PFOS in Maternal Blood, Cord Blood and Breast Milk in Busan
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 Title & Authors
Distribution of PFOA and PFOS in Maternal Blood, Cord Blood and Breast Milk in Busan
Suh, Chun-Hui; Lee, Chae-Kwan; Kim, Kun-Hyung; Son, Byung-Chul; Lee, Jong-Tae;
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Objectives: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are man-made, persistent global pollutants widely diffused throughout the environment. They have been even found in the cord blood and breast milk of humans. Furthermore evidence of developmental toxicity in animals exists. To assess the distribution of maternal and fetal exposure to PFOS and PFOA, we analyzed paired maternal blood, cord blood and breast milk samples. Methods: Maternal blood, cord blood and breast milk were collected from 150 volunteers from the general population (aged 20-40, mean ) of the city of Busan in 2009-2010. The samples were extracted using the weak anion exchange and solid-phase extraction methods and quantified by high-performance liquid chromatograph (HPLC, Agilent 1200 Series) coupled with an Triple Quad LC-MS/MS system (Agilent 6410). Results: Median PFOA and PFOS concentrations in maternal blood were 2.18 and 3.32 ng/ml, in cord blood were 0.83 and 0.58 ng/ml, and in breast milk were 0.13 and 0.11 ng/ml, respectively. PFOS and PFOA concentrations were significantly correlated among matrices (Spearson's , p = 0.05 for maternal blood; , p < 0.01 for cord blood; p < 0.01 for breast milk). The ratio of cord blood/maternal blood was 0.39 for PFOA and 0.19 for PFOS. The ratio of breast milk/maternal blood was 0.07 for PFOA and 0.06 for PFOS. Conclusions: Our findings suggest that PFOA and PFOS exposure through the placenta was more prominent than through breast milk among Korean neonates born in Busan. The transfer efficiency of maternal blood to breast milk was similar between PFOA and PFOS, but that of maternal blood to cord blood was higher in PFOA than PFOS.
Perfluorooctanoic acid;Perfluorooctane sulfonate;Maternal blood;Cord blood;Breast milk;
 Cited by
식품 포장재 중의 퍼플루오르옥탄설포네이트 분석,김일영;김애경;정보경;신영;김지영;김정헌;채영주;

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산모의 한약 복용이 모유에 미치는 영향 - HPLC와 LC/MS/MS를 이용한 생화탕 지표성분 분석 -,박가영;이아영;반지혜;박정경;이은희;

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