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Fates and Removals of Micropollutants in Drinking Water Treatment
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 Title & Authors
Fates and Removals of Micropollutants in Drinking Water Treatment
Nam, Seung-Woo; Zoh, Kyung-Duk;
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Micropollutants emerge in surface water through untreated discharge from sewage and wastewater treatment plants (STPs and WWTPs). Most micropollutants resist the conventional systems in place at water treatment plants (WTPs) and survive the production of tap water. In particular, pharmaceuticals and endocrine disruptors (ECDs) are micropollutants frequently detected in drinking water. In this review, we summarized the distribution of micropollutants at WTPs and also scrutinized the effectiveness and mechanisms for their removal at each stage of drinking water production. Micropollutants demonstrated clear concentrations in the final effluents of WTPs. Although chronic exposure to micropollutants in drinking water has unclear adverse effects on humans, peer reviews have argued that continuous accumulation in water environments and inappropriate removal at WTPs has the potential to eventually affect human health. Among the available removal mechanisms for micropollutants at WTPs, coagulation alone is unlikely to eliminate the pollutants, but ionized compounds can be adsorbed to natural particles (e.g. clay and colloidal particles) and metal salts in coagulants. Hydrophobicities of micropollutants are a critical factor in adsorption removal using activated carbon. Disinfection can reduce contaminants through oxidation by disinfectants (e.g. ozone, chlorine and ultraviolet light), but unidentified toxic byproducts may result from such treatments. Overall, the persistence of micropollutants in a treatment system is based on the physico-chemical properties of chemicals and the operating conditions of the processes involved. Therefore, monitoring of WTPs and effective elimination process studies for pharmaceuticals and ECDs are required to control micropollutant contamination of drinking water.
Micropollutants;pharmaceuticals;endocrine disruptors;water treatment plant;coagulation;adsorption;chlorination;
 Cited by
Stackelberg PE, Gibs J, Furlong ET, Meyer MT, Zaugg SD, Lippincott RL. Efficiency of conventional drinking-water-treatment processes in removal of pharmaceuticals and other organic compounds. Sci Total Environ. 2007; 377(2-3): 255-272. crossref(new window)

Halling-Sorensen B, Nors Nielsen S, Lanzky P, Ingerslev F, Holten Ltzhoft H, Jorgensen S, Occurrence, fate and effects of pharmaceutical substances in the environment-a review. Chemosphere. 1998; 36(2): 357-393. crossref(new window)

Vieno N, Tuhkanen T, Kronberg L. Removal of pharmaceuticals in drinking water treatment: effect of chemical coagulation. Environ Technol. 2006; 27(2): 183-192. crossref(new window)

Ratola N, Cincinelli A, Alves A, Katsoyiannis A. Occurrence of organic microcontaminants in the wastewater treatment process. A mini review. J. Hard Mater. 2012; 239-240: 1-18. crossref(new window)

Stackelberg PE, Furlong ET, Meyer MT, Zaugg SD, Henderson AK, Reissman DB. Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-watertreatment plant. Sci Total Environ. 2004; 329(1-3): 99-113. crossref(new window)

Kim Y, Choi K, Jung J, Park S, Kim PG, Park J. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ Int. 2007; 33(3): 370-375. crossref(new window)

Kumar A, Chang B, Xagoraraki I. Human health risk assessment of pharmaceuticals in water: issues and challenges ahead. Int. J Environ Res Publ Health. 2010; 7(11): 3929-3953. crossref(new window)

Korea Pharmaceutical Manufacturers Association. Statistics of Korea Pharmaceutical Manufacturers Association. 2010. p.5-6.

Kumar A, Xagoraraki I. Pharmaceuticals, personal care products and endocrine-disrupting chemicals in U.S. surface and finished drinking waters: A proposed ranking system. Sci Total Environ. 2010; 408(23): 5972-5989. crossref(new window)

Kim SD, Cho J, Kim IS, Vanderford BJ, Snyder SA. Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. Water Res. 2007; 41(5): 1013-1021. crossref(new window)

Huerta-Fontela M, Galceran MT, Ventura F. Occurrence and removal of pharmaceuticals and hormones through drinking water treatment. Water Res. 2011; 45 (3): 1432-1442. crossref(new window)

Westerhoff P, Yoon Y, Snyder S, Wert E. Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes. Environ Sci Technol. 2005; 39(17): 6649-6663. crossref(new window)

Adams C, Wang Y, Loftin K, Meyer M. Removal of antibiotics from surface and distilled water in conventional water treatment processes. J Environ Eng. 2002; 128 (3): 253-260. crossref(new window)

European environment agency. Environmental terminology and discovery service (ETDS). Available: http: // glossary.eea. html?term=micropollutant. [accessed 9 July 2013].

Network of reference laboratories for monitoring of emerging environmental pollutions in Europe. Why do we need to address emerging substances ? Available: module=public/about_us/comment_substances&menu2 =public/about_us/about_us. [accessed 9 August 2013].

United states environmental protection agency. Water: contaminants of emerging concern. Available: [accessed 9 August 2013].

International environment forum. IEF sustapedia an encyclopedia of sustainability. Available: http:// [accessed 9 August 2013].

Thomas PM, Foster GD. Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process. Environ Toxicol. 2005; 24(1): 25-30. crossref(new window)

Prevedouros K, Cousins IT, Buck RC, Korzeniowski SH. Sources, fate and transport of perfluorocarboxylates. Environ Sci Technol. 2006; 40(1): 32-44. crossref(new window)

Birkett JW, Lester JN. Endocrine disrupters in wastewater and sludge treatment processes. CRC Press: 2003. p. 5-7.

Heberer T, Reddersen K, Mechlinski A. From municipal sewage to drinking water: fate and removal of pharmaceutical residues in the aquatic environment in urban areas. Water Sci Technol. 2002; 46(3): 81-88.

Caliman FA, Gavrilescu M. Pharmaceuticals, personal care products and endocrine disrupting agents in the environment a review. CLEAN. 2009; 37(4-5): 277-303.

Assmuth T, Louekari K. Research for management of environmental risks from endocrine disruptors, 448. The Finnish Environment: environmental protection; 2001. p.82-84.

Hazardous substances data bank. Comprehensive, peer-reviewed toxicology data for about 5,000 chemicals. Available: sis/htmlgen?HSDB. [accessed 31 July 2013].

World Health Organization. IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 79, spplement 7. 1987. p.365-370.

Nguyen LN, Hai FI, Kang J, Nghiem LD, Price WE, Guo W et al. Comparison between sequential and simultaneous application of activated carbon with membrane bioreactor for trace organic contaminant removal. Bioresour Technol. 2012; 130: 412-417.

Rogers HR. Sources, behaviour and fate of organic contaminants during sewage treatment and in sewage sludges. Sci Total Environ. 1996; 185(1-3): 3-26. crossref(new window)

Richardson ML, Bowron JM. The fate of pharmaceutical chemicals in the aquatic environment. J Pharm Pharmacol. 1985; 37(1): 1-12. crossref(new window)

Zoeteman B, Harmsen K, Linders J, Morra C, Slooff W. Persistent organic pollutants in river water and ground water of the Netherlands. Chemosphere. 1980; 9: 231-249. crossref(new window)

Gledhill W. Biodegradation of 3, 4, 4'-trichlorocarbanilide, TCC in sewage and activated sludge. Water Res. 1975; 9(7): 649-654. crossref(new window)

Grundwasser KiBO-u, Heberer T, Schmidt-Bumler K, Stan H. Occurrence and distribution of organic contaminants in the aquatic system in Berlin. Part I: Drug residues and other polar contaminants in Berlin surface and groundwater. Acta hydrochim hydrobiol. 1998; 26(5): 272-278. crossref(new window)

McLachlan J, Guillette L, Iguchi Jr T, Toscano J. Fate and analysis of pharmaceutical residues in the aquatic environment. Ann NY Acad Sci. 2001; 948:153.

Gibs, J, Stackelberg PE, Furlong ET, Meyer M, Zaugg SD, Lippincott RL. Persistence of pharmaceuticals and other organic compounds in chlorinated drinking water as a function of time. Sci Total Environ. 2007; 373(1): 240-249. crossref(new window)

Benotti M, Trenholm R, Vanderford B, Holady J, Stanford B, Snyder S. Pharmaceuticals and endocrine disrupting compounds in US drinking water. Environ Sci Technol. 2009; 43(3): 597-603. crossref(new window)

Boleda MR, Galceran MT, Ventura F. Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments. Environ Pollut. 2011; 159(6): 1584-1591. crossref(new window)

Gregory J, Duan J. Hydrolyzing metal salts as coagulants. Pure Appl Chem. 2001; 73(12): 2017-2026. crossref(new window)

Duan J, Gregory J. Coagulation by hydrolysing metal salts. Adv Colloid Interface Sci. 2003; 100-102: 475-502. crossref(new window)

Ye C, Wang D, Shi B, Yu J, Qu J, Edwards M, et al. Alkalinity effect of coagulation with polyaluminum chlorides: Role of electrostatic patch. Colloids Surf., A 2007; 294(1-3): 163-173. crossref(new window)

Ternes TA, Meisenheimer M, McDowell D, Sacher F, Brauch HJ, Haist-Gulde B et al. Removal of Pharmaceuticals during Drinking Water Treatment. Environ Sci Technol. 2002; 36(17): 3855-3863. crossref(new window)

Choi KJ, Kim SG, Kim SH. Removal of antibiotics by coagulation and granular activated carbon filtration. J Hazard Mater. 2008; 151(1): 38-43. crossref(new window)

Alexander JT, Hai FI, Al-aboud TM. Chemical coagulation-based processes for trace organic contaminant removal: Current state and future potential. J Environ Manage. 2012; 111(30): 195-207. crossref(new window)

Huerta-Fontela M, Galceran MT, Ventura F. Stimulatory drugs of abuse in surface waters and their removal in a conventional drinking water treatment plant. Environ Sci Technol. 2008; 42(18): 6809-6816. crossref(new window)

Vieno N. Occurrence of pharmaceuticals in Finnish sewage treatment plants, surface waters, and their elimination in drinking water treatment processes. Tampere University of Technology. Publication;666. 2007. p.28-34.

Carballa M, Omil F, Lema JM. Removal of cosmetic ingredients and pharmaceuticals in sewage primary treatment. Water Res. 2005; 39(19): 4790-4796. crossref(new window)

Carballa M, Omil F, Lema J. Removal of pharmaceuticals and personal care products (PPCPs) from municipal wastewaters by physico-chemical processes. Elec J Env Agricult Food Chem. 2003; 2(2): 309-313.

Suarez S, Lema JM, Omil, F. Pre-treatment of hospital wastewater by coagulation flocculation and flotation. Bioresour Technol. 2009; 100(7): 2138-2146. crossref(new window)

Roccaro P, Sgroi M, Vagliasindi FG. Removal of xenobiotic compounds from wastewater for environment protection: treatment processes and costs. Chem eng trans. 2013; 32: 505-510.

Stumm W, Morgan JJ, Drever JI. Aquatic chemistry. J Environ Qual. 1996; 25(5): 1162.

Snyder SA, Adham S, Redding AM, Cannon FS, DeCarolis J, Oppenheimer J, et al. Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals. Desalination. 2007; 202(1): 156-181. crossref(new window)

Choi KJ, Kim SG, Kim CW, Park JK. Removal efficiencies of endocrine disrupting chemicals by coagulation/flocculation, ozonation, powdered/granular activated carbon adsorption, and chlorination. Korean J Chem Eng. 2006; 23(3): 399-408. crossref(new window)

Summers RS, Roberts PV. Activated carbon adsorption of humic substances: I. Heterodisperse mixtures and desorption. J. Colloid Interf. Sci. 1988; 122(2): 367-381. crossref(new window)

Avdeef A. Absorption and drug development: solubility, permeability, and charge state. 2nd ed. Wiley: 2012. p.31-34.

Cantrell KJ, Serne RJ, Last GV. Applicability of the linear sorption isotherm model to represent contaminant transport processes in site-wide performance assessments. Pacific Northwest National Laboratory. Technical report PNNL-14576. 2003. p.1-6.

Yu Z, Peldszus S, Huck PM. Adsorption characteristics of selected pharmaceuticals and an endocrine disrupting $compound^{\circ}^{TM}$Naproxen, carbamazepine and $nonylphenol^{\circ}^{TM}$on activated carbon. Water res. 2008; 42(12): 2873-2882. crossref(new window)

Hari AC, Paruchuri RA, Sabatini DA, Kibbey TC. Effects of pH and cationic and nonionic surfactants on the adsorption of pharmaceuticals to a natural aquifer material. Environ Sci Technol. 2005; 39(8): 2592-2598. crossref(new window)

Rossner A, Snyder SA, Knappe, DR. Removal of emerging contaminants of concern by alternative adsorbents. Water res. 2009; 43(15): 3787-3796. crossref(new window)

Richardson SD. Disinfection by-products and other emerging contaminants in drinking water. Trends Anal Chem. 2003; 22(10): 666-684. crossref(new window)

Yiasoumi W. Water disinfecting techniques for plant pathogen control. Combined proceedings-IPPS. 2005; 55: .138.

Jolley RL, Gorchev H, Hamilton JrD. Water chlorination: environmental impact and health effects. Volume 2 Ann Arbor Science Publishers, Inc Ann Arbor, MI: 1978. p.78-220

Heasley VL, Anderson ME, Combes DS, Elias DS, Gardner JT, Hernandez ML, et al. Investigations of the structure and reactions of the intermediate in the chlorination of resorcinol. Environ Toxicol Chem. 1993; 12(9): 1653-1659. crossref(new window)

Gallard H, von Gunten U. Chlorination of phenols: Kinetics and formation of chloroform. Environ Sci Technol. 2002; 36(5): 884-890. crossref(new window)

Pinkston KE, Sedlak DL. Transformation of aromatic ether-and amine-containing pharmaceuticals during chlorine disinfection. Environ Sci Technol. 2004; 38(14): 4019-4025. crossref(new window)

Sim WJ, Lee JW, Oh JE. Occurrence and fate of pharmaceuticals in wastewater treatment plants and rivers in Korea. Environ Pollut. 2010; 158(5): 1938-1947. crossref(new window)

Bedner M, MacCrehan WA. Transformation of acetaminophen by chlorination produces the toxicants 1, 4-benzoquinone and N-acetyl-p-benzoquinone imine. Environ Sci Technol. 2006; 40(2): 516-522. crossref(new window)

Quintana JB, Rodil R, Lpez-Maha P, Muniategui- Lorenzo S, Prada-Rodrguez D. Investigating the chlorination of acidic pharmaceuticals and by-product formation aided by an experimental design methodology. Water Res. 2010; 44(1): 243-255. crossref(new window)

Dodd MC, Huang CH. Transformation of the antibacterial agent sulfamethoxazole in reactions with chlorine: kinetics, mechanisms, and pathways. Environ Sci Technol. 2004; 38(21): 5607-5615. crossref(new window)

Melton TC, Brown SD. The fate of sulfamethazine in sodium-hypochlorite-treated drinking water: monitoring by LC-$MS^{n}$-IT-TOF. J Med Chem. 2012; 2012: 1-6.

Yamamoto T, Yasuhara A. Chlorination of bisphenol A in aqueous media: formation of chlorinated bisphenol A congeners and degradation to chlorinated phenolic compounds. Chemosphere. 2002; 46(8): 1215-1223. crossref(new window)

Hu JY, Xie GH, Aizawa T. Products of aqueous chlorination of 4-nonylphenol and their estrogenic activity. Environ Toxicol Chem. 2002; 21(10): 2034- 2039. crossref(new window)

Sojic D, Despotovi V, Ori D, Szab E, Arany E, Armakovi S, et al. Degradation of thiamethoxam and metoprolol by UV, $O_{3}$ and UV/$O_{3}$ hybrid processes: Kinetics, degradation intermediates and toxicity. J Hydrol. 2012; 472-473: 314-327. crossref(new window)