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Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)
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 Title & Authors
Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)
Hee Dong Han; Sung Soo Kim; Ho Suk Choi; Byung Cheol Shin;
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 Abstract
This study has investigated the temperature-sensitive liposomes, which release anticancer drug(doxorubicin) at the hyperthermia temperature. The temperature-sensitive liposomes were modified with a copolymers of N-isopropylacrylamide(NIPAAm) and acrylamide(AAm), which exhibit a lower critical solution temperature (LCST) at the hyperthermia temperature. The release of doxorubicin from the modified liposomes was determined by measuring the fluorescence intensity with changing temperature and time. The release of doxorubicin from liposomes modified with poly(NIPAAm-co-AAm) copolymer was increased significantly, because poly(NIPAAm-co-AAm) could undergo the conformational transition in the narrow hyperthermia temperature region. Moreover, we observed that doxorubicin released from liposomes within 5 minutes, and the size of modified liposomes was 120~170 nm. In this study, we have prepared temperature-sensitive liposomes which could be controlled by temperature. They can be applied in the field of a drug delivery system for tumor targeting by temperature control.
 Keywords
Hyperthermia; Tumor Targeting; Liposomes; Temperature-Sensitive Polymer;
 Language
Korean
 Cited by
1.
리포솜이 함유된 N-이소프로필아크릴아마이드의 공중합체로부터 온도에 따른 약물의 방출,박영심;한희동;홍성욱;김승수;신병철;

폴리머, 2004. vol.28. 1, pp.59-66
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