JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Surface Mmodification of Poly(DL-lactide-co-glycolide) Nanoparticle
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Surface Mmodification of Poly(DL-lactide-co-glycolide) Nanoparticle
Oh, Yu-Mi; Jung, Taek-Kyu; Chi, Sang-Cheol; Shin, Byung-Cheol;
  PDF(new window)
 Abstract
We studied on preparation of nanoparticles modified surface using biodegradable polymer, poly(DL-lactide-co-glycolide) (PLGA). Two kinds of PLGA nanoparticles were prepared by a spontaneous emulsification solvent diffusion (SESD) method using cetyltrimethylammonium chloride (CTAC) and tetradecyltrimethylammonium bromide (TTAB) as a cationic surfactant and polyethylene glycol-block-polypropylene glycol copolymer (Lutrol F68) as a nonionic surfactant. Model protein was coated on the surface of nanoparticles by the ionic complexation. The model protein was that influenza vaccine (, B strain) labeled with NHS-fluorescein. The sizes of cationic nanoparticles were 140-160 nm and the surface charges were 50-60 mV. The sizes of nonionic nanoprticles were 80-90 nm and the surface charge was -10 mV. After coating vaccine on the surface of nanoparticles, the sizes of cationic nanoparticles were increased to 380-400 nm and the size of nonionic nanoparticles was not increased. The amount of coated vaccine on the cationic nanoparticles was 22.73 /mg.
 Keywords
PLGA;Nanoparticle;Vaccine;Cationic Surfactant;Surface Modification;
 Language
Korean
 Cited by
1.
Polymeric nanoparticles, micelles and polymersomes from amphiphilic block copolymer,;;;;

The Korean Journal of Chemical Engineering, 2010. vol.27. 3, pp.731-740 crossref(new window)
1.
Polymeric nanoparticles, micelles and polymersomes from amphiphilic block copolymer, Korean Journal of Chemical Engineering, 2010, 27, 3, 731  crossref(new windwow)
 References
1.
Brannon-Peppas, L. Int. J. Pharm. 1995, 116, 1. crossref(new window)

2.
Labhasetwar, V.; Song, C.; Levy, R. J. Adv. Drug Deliv. Rev. 1997, 24, 63. crossref(new window)

3.
Kreuter, J.; Speiser, P. J. Pharm. Sci. 1976, 65, 1624. crossref(new window)

4.
Couvreur, P.; Kante, B.; Roland, M.; Speiser P. J. Pharm. Sci. 1979, 68, 1521. crossref(new window)

5.
Couvreur, P.; Kante, H.; Lenaerts, V.; Scailteur V.; Roland, M.; Speiser P. J. Pharm. Sci. 1980, 69, 199. crossref(new window)

6.
Couvreur, P.; Kante, B.; Grislain, L.; Roland, M.; Speiser P. J. Pharm. Sci. 1982, 71, 790. crossref(new window)

7.
Allemann, E.; Gurny, R.; Doelker, E. Eur. J. Pharm. Biopharm. 1993, 39, 173.

8.
Quintanar-Guerrero, D.; Allemann, E.; Fessi, H.; Doelker, E. Drug Dev. Ind. Pharm. 1998, 24, 1113. crossref(new window)

9.
Zimmer, A.; Kreuter, J. Adv. Drug Deliv. Rev. 1995, 16, 61. crossref(new window)

10.
Peppas L. B. Int. J. Pharm. 1995, 116, 1. crossref(new window)

11.
Leroux, J.-C.; Allemann, E.; De Jaeghere, F.; Doelker, E.; Gurny, R. J. Controlled Release 1996, 39, 339. crossref(new window)

12.
Soppimath, K. S.; Aminabhavi, T. M.; Kulkami, A R.; Rudzinski, W. E. J. Controlled Release 2001, 70, 1. crossref(new window)

13.
Govender, T.; Stolnik, S.; Garnett, M. C.; Illum, L.; Davis, S. S. J. Controlled Release 1999, 57, 171. crossref(new window)

14.
O'Hagan, D. T. Adv. Drug Deliv. Rev. 1998, 34, 305. crossref(new window)

15.
Michael, V.; O'Hagan, D. T. Adv. Drug Deliv. Rev. 2001, 51, 127. crossref(new window)

16.
Vila, A.; Sanchez, A.; Tobio, M.; Evora, C., Soriano, I.; McCallion, O.; Alonso, M. J. Pharm. Res. 1998, 15, 270. crossref(new window)

17.
Murakami, H.; Kobayashi, M.; Takeuchi, H.; Kawashima, Y. Int. J. Pharm. 1999, 187, 143. crossref(new window)

18.
Hiraku, O.; Yoshiham, M. Biomaterials 1999, 20, 175. crossref(new window)

19.
Park, S. J.; Kim, S. H.; Lee, I.R; Lee, H. H.; Hong, S. K. Polymer (Korea) 2002, 26(3), 326.

20.
Murakami, H.; Kawashima, Y.; Niwa, T.; Hino, T.; Takeuchi, H.; Kobayashi, H. Int. J. Pharm. 1997, 149, 43. crossref(new window)