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Synthesis of Potential Anticancer 6-Allylthio-3-aminopyridazine Derivatives
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 Title & Authors
Synthesis of Potential Anticancer 6-Allylthio-3-aminopyridazine Derivatives
Park, Eun-Hee; Park, Myung-Sook;
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 Abstract
A series of new 6-allylthio-3-aminopyridazine derivatives was synthesized through allylthiolation, amination and expected for anti-tumor activity. The pyridazine nucleus was obtained by condensing hydrazine monohydrate with maleic anhydride. 3,6-Dichloropyridazine was synthesized from 3,6-dihydroxypyridazine by treating with POCl3. 6-Allylthio-3-chloropyridazine was prepared from the reaction of 3,6-dichloropyridazine with allylmercaptan and sodium hydroxide. The heterocycles with nitrogen nucleophile such as morpholine, piperazine, pyrazole, imidazole, pyrrolidine, piperidine, perhydroazepine, and perhydroazocine were introduced into 3-position of pyridazine ring. The substitution reaction of 6-allylthio-3-chloropyridazine with heteroamines was performed by refluxing for 24~48 h in n-buthanol with NH4Cl.
 Keywords
Amination;Substitution;Aminopyridazines;Heterocyclopyridazines;
 Language
English
 Cited by
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