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Resolution of Aryl α-Aminoalkyl Ketones on a Doubly Tethered Liquid Chromatographic Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid
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 Title & Authors
Resolution of Aryl α-Aminoalkyl Ketones on a Doubly Tethered Liquid Chromatographic Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid
Jin, Kab-Bong; Kim, Hee-Jin; Hyun, Myung-Ho;
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 Abstract
A doubly tethered chiral stationary phase (CSP) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied to the resolution of various aryl -aminoalkyl ketones with the use of 80% ethanol in water containing 10 mM sulfuric acid as a mobile phase. The chiral resolution was quite successful, the separation factors () and the resolutions () being in the range of 1.39-2.05 and 3.18-5.22, respectively. The separation factors () on the doubly tethered CSP were slightly worse than those on the corresponding singly tethered CSP. However, the resolutions () on the doubly tethered CSP were generally greater than those on the corresponding singly tethered CSP. The chromatographic behaviors for the resolution of aryl -aminoalkyl ketones on the doubly tethered CSP were demonstrated to be dependent on the type and the content of the organic and acidic modifiers in aqueous mobile phase and the column temperature.
 Keywords
Aryl -aminoalkyl ketone;Chiral stationary phase;(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid;Liquid chromatography;Resolution;
 Language
English
 Cited by
1.
Racemic drug resolution: a comprehensive guide, Anal. Methods, 2016, 8, 42, 7567  crossref(new windwow)
2.
Liquid chromatographic enantioseparations on crown ether-based chiral stationary phases, Journal of Chromatography A, 2016, 1467, 19  crossref(new windwow)
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