JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Facile Synthesis of New Pyrazolopyrimidine Derivatives of Potential Biosignificant Interest
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Facile Synthesis of New Pyrazolopyrimidine Derivatives of Potential Biosignificant Interest
Aly, Aly A.; El-Karim, Iman A. Gad;
  PDF(new window)
 Abstract
An easy and efficient route for the synthesis of some imidazo[1,2-c]pyrazolo[4,3-e]pyrimidines 3-6, imidazo[1,2-c]pyrazolo[4,3-e]triazine 8, pyrazolo[4,3-e]triazolo[1,5-c]pyrimidines 12-15 and pyrazolo-[3`,4`:4,5]pyrimido[1,6-b]triazines 16, 17 was described through the reaction of readily available 5-aminopyrazole-4-carbonitrile 1 with different reagents. The in vitro antimicrobial activity of some synthesized compounds was examined. Most of the tested compounds proved to be active as antibacterial and antifungal agents.
 Keywords
Imidazole pyrimidine;Pyrazole and triazine;
 Language
English
 Cited by
1.
Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of Imidazolone Fused Pyrazolo[1,5-a]pyrimidine Derivatives, Journal of Heterocyclic Chemistry, 2017, 54, 3, 1904  crossref(new windwow)
2.
Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3- d ]pyrimidin-4(3 H )-one schiff bases, Bioorganic & Medicinal Chemistry Letters, 2016, 26, 3, 836  crossref(new windwow)
3.
3-Amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno [2,3-d ]pyrimidine: An Effecient Key Precursor for Novel Synthesis of Some Interesting Triazines and Triazepines as Potential Anti-Tumor Agents, Molecules, 2012, 17, 12, 11538  crossref(new windwow)
4.
Antimicrobial Activity of Novel Tetra- and Penta-azaheterocyclic Ring Systems, Journal of Heterocyclic Chemistry, 2017, 54, 1, 610  crossref(new windwow)
5.
Synthesis, antimicrobial, and antioxidant activities of some new indole analogues containing pyrimidine and fused pyrimidine systems, Medicinal Chemistry Research, 2012, 21, 11, 3809  crossref(new windwow)
 References
1.
Tollefson, M. B.; Acker, B. A.; Jacobsen, E. J.; Hughes, R. O.; Walker, J. K.; Fox, D. N. A.; Palmer, M. J.; Freeman, S. K.; Yu, Y. Bond, Bioorg. Med. Chem. Lett. 2010, 20(10), 3120. crossref(new window)

2.
Kumar, R.; Joshi, Y. C. Indian. J. Chem. Sect. B 2010, 49B(1), 84.

3.
Ivachtchenko, A. V.; Dmitriev, D. E.; Golovina, E. S.; Dubrovskaya, E. S.; Kadieva, M. G.; Koryakova, A. G.; Kysil, V. M.; Mitkin, O. D.; Tkachenko, S. E.; Okun, I. M.; Vorobiov, A. A. Bioorg. Med. Chem. Lett. 2010, 20(7), 2133. crossref(new window)

4.
Bakavoli, M.; Bagherzadeh, G.; Vaseghifar, M.; Shiri, A.; Pordel, M.; Mashreghi, M.; Pordeli, P.; Araghi, M. Eur. J. Med. Chem. 2010, 4(2), 647.

5.
Curran, K. J.; Verheijen, J. C.; Kaplan, J.; Richard, D. J.; Toral-Barza, L.; Hollander, I.; Lucas, J.; Ayral-Kaloustian, S.; Yu, K.; Zask, A. Bioorg. Med. Chem. Lett. 2010, 20(4), 1440. crossref(new window)

6.
Kim, I.; Song, J. H.; Park, C. M.; Jeong, J. W.; Kim, H. R.; Ha, J. R.; No, Z.; Hyun, Y. L.; Cho, Y. S.; Kang, N. S.; Jeon, D. J. Bioorg. Med. Chem. Lett. 2010, 20(3), 922. crossref(new window)

7.
Bakavoli, M.; Bagherzadeh, G.; Vaseghifar, M.; Shiri, A.; Pordel, M.; Mashreghi, M.; Pordeli, P.; Araghi, M. Eur. J. Med. Chem. 2010, 45(2), 647. crossref(new window)

8.
Ali, H. I.; Fujita, T.; Akaho, E.; Nagamatsu, T. Molecular Design 2010, 24(1), 57.

9.
Schenone, S.; Brullo, C.; Bruno, O.; Bondavalli, F.; Mosti, L.; Maga, G.; Crespan, E.; Carraro, F.; Manetti, F.; Tintori, C.; Botta, M. Eur. J. Med. Chem. 2008, 43(12), 2665. crossref(new window)

10.
Rana, P. B.; Patel, J. A.; Mistry, B. D.; Desai, K. R. Indian. J. Chem. Sect. B 2009, 48B(11), 1601.

11.
Gilbert, A. M.; Nowak, P.; Brooijmans, N.; Bursavich, M. G.; Dehnhardt, C.; Santos, E. D.; Feldberg, L. R.; Hollander, I.; Kim, S.; Lombardi, S.; Park, K.; Venkatesan, A. M.; Mallon, R. Bioorg. Med. Chem. Lett. 2010, 20(2), 636. crossref(new window)

12.
Verheijen, J. C.; Richard, D. J.; Curran, K.; Kaplan, J.; Lefever, M.; Nowak, P.; Malwitz, D. J.; Brooijmans, N.; Toral-Barza, L.; Zhang, W.-G.; Lucas, J.; Hollander, I.; Ayral-Kaloustian, S.; Mansour, T. S.; Yu, K.; Zask, A. J. Med. Chem. 2009, 52(24), 8010. crossref(new window)

13.
Karci, F.; Karci, F. Dyes and Pigments 2008, 76(1), 147. crossref(new window)

14.
Brough, P. A.; Barril, X.; Beswick, M.; Dymock, B. W.; Drysdale, M. J.; Wright, L.; Grant, K.; Massey, A.; Surgenor, A.; Workman, P. Bioorg. Med. Chem. Lett. 2005, 15(23), 5197. crossref(new window)

15.
Aly, A. A. Curr. Org. Chem. 2009, 13, 1758. crossref(new window)

16.
El Ashry, E. S. H.; Aly, A. A.; Aouad, M. R.; Amer, M. R. Nucleosides, Nucleotides Nucleic Acids. 2010, 29, 698. crossref(new window)

17.
Aly, A. A. J. Heterocycl. Chem. 2008, 45(4), 993. crossref(new window)

18.
Domling, A. Chem. Rev. 2006, 106(1), 17. crossref(new window)

19.
Zhou, Y.; Liu, G.; Chen, J.; Reddy, P. S. M. M.; Yoon, I. S.; Zhang, M.; Zhang, B.; Barber, J. R.; Ng, S. C. Bioorg. Med. Chem. Lett. 2009, 19(21), 6114. crossref(new window)

20.
Sztanke, K.; Markowski, W.; CEwieboda, R.; Polak B. Eur. J. Med. Chem. 2010, 45(6), 2644. crossref(new window)

21.
Leiferet, C.; Chidbouree, S.; Hampson, S.; Workman, S.; Sigee, D.; Epton, H. A.; Harbour, A. J. Appl. Bacteriol. 1995, 78, 97. crossref(new window)