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Synthesis and Cytotoxicity Evaluation of Phosphorylated Derivatives of Ribavirin
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 Title & Authors
Synthesis and Cytotoxicity Evaluation of Phosphorylated Derivatives of Ribavirin
Rao, Valasani Koteswara; Reddy, Sanapalli Subba; Babu, Kilaru Raveendra; Kumar, Kuntrapakam Hema; Ghosh, Sunil Kumar; Raju, Chamarthi Naga;
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 Abstract
Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, , , NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.
 Keywords
Phosphorylated ribavirins;Trypan blue assay;MTT assay;MCF-7 cell lines;
 Language
English
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