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Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
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 Title & Authors
Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
Thomas, Asha B.; Nanda, Rabindra K.; Kothapalli, Lata P.; Deshpande, Avinash D.;
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 Abstract
A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff`s bases, followed by the cyclocondensation of Schiff`s bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.
 Keywords
Antimicrobial activity;Microwave irradiation;Sonication;4-thiazolidinones;Resistant bacterial strains;
 Language
English
 Cited by
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Novel hydrazone derivatives containing pyridine amide moiety: Design, synthesis, and insecticidal activity, Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4, 1161  crossref(new windwow)
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