Advanced SearchSearch Tips
Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
Thomas, Asha B.; Nanda, Rabindra K.; Kothapalli, Lata P.; Deshpande, Avinash D.;
  PDF(new window)
A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff`s bases, followed by the cyclocondensation of Schiff`s bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.
Antimicrobial activity;Microwave irradiation;Sonication;4-thiazolidinones;Resistant bacterial strains;
 Cited by
Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole, Chemistry Central Journal, 2013, 7, 1, 64  crossref(new windwow)
Design and Synthesis of Arylthiophene-2-Carbaldehydes via Suzuki-Miyaura Reactions and Their Biological Evaluation, Molecules, 2013, 18, 12, 14711  crossref(new windwow)
Novel hydrazone derivatives containing pyridine amide moiety: Design, synthesis, and insecticidal activity, Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4, 1161  crossref(new windwow)
Tomasz, A.; Eng. N. J. Med. 1994, 330, 1247.

Witte, W.; Cuny, C.; Klare, I.; Nubel, U.; Strommenger, B.; Werner, G. Int. J. Med. Microbial. 2008, 298, 365.

Vicini, P.; Zani, F.; Cozzini, P.; Doytchinova, I. Eur. J. Med. Chem. 2002, 37, 553. crossref(new window)

Loncle, C.; Brunel, J. M.; Vidal, N.; Dherbomez, M.; Letourneux, Y. Eur. J. Med. Chem. 2004, 39, 1067. crossref(new window)

Sridhar, S. K.; Pandeya, S. N.; Stables, J. P.; Atmakuru, R. Eur. J. Pharm. Sci. 2002, 16, 129. crossref(new window)

Todeschini, A. R.; Miranda, A. L. P.; Silva, K. C. M.; Parrini, S. C.; Barreiro, E. J. Eur. J. Med. Chem. 1998, 33, 189. crossref(new window)

Melnyk, P.; Leroux, V.; Sergheraert, C.; Grellier, P. Bioorg. Med. Chem. Lett. 2006, 16, 31. crossref(new window)

Kaymakcioglu, B. K.; Rollas, S. Farmaco 2002, 57, 595. crossref(new window)

Patole, J.; Sandbhor U.; Padhye, S.; Deobagkar, D. N.; Anson, C. E.; Powell, A. Bioorg. Med. Chem. Lett. 2003, 13, 51. crossref(new window)

Geronikaki, A. A.; Lagunin, A. A.; Hadjipavlou-Litina, D. I.; Eleftheriou, P. T.; Filimonov, D. A.; Poroikov, V. V.; Alam, I.; Saxena, A. K. J. Med. Chem. 2008, 51, 1601. crossref(new window)

Hrib, N. J.; Jurcak, J. G.; Bregna, D. E.; Burgher, K. L.; Hartman, H. B.; Kafka, S.; Kerman, L. L.; Kongsamut, S.; Roehr, J. E.; Szewczak, M. R.; Woods-Kettelberger, A. T.; Corbett, R. J. Med. Chem. 1996, 39, 4044. crossref(new window)

El-Gaby, M. S. A.; El-Hag Ali, G. A. M.; El-Maghraby, A. A.; Abd El-Rahman, M. T.; Helal, M. H. M. Eur. J. Med. Chem. 2009, 44, 4148. crossref(new window)

Khan, S. A.; Yusuf, M. Eur. J. Med. Chem. 2009, 44, 2597. crossref(new window)

M. de Aquino, T.; Liesen, A. P.; da Silva, R. E. A.; Lima, V. T., Carvalho, C. S.; de Faria, A. R.; de Araujo, J. M.; de Lima, J. D.; Alves, A. J.; de Melo, E. J. T.; Goes, A. J. S. Bioorg. Med. Chem. 2008, 16, 446. crossref(new window)

Liu, H. L.; Li, Z.; Anthonsen, T. Molecules 2000, 5, 1055. crossref(new window)

Knutsen, L. J. S.; Hobbs, C. J.; Earnshaw, C. G.; Fiumana, A.; Gilbert, J.; Mellor, S. L.; Radford, F.; Smith, N. J.; Birch, P. J.; Burley, J. R.; Ward, S. D. C.; James, L. F. Bioorg. Med. Chem. Lett. 2007, 17, 662. crossref(new window)

Wrobel, J.; Jetter, J.; Kao, W., Rogers, J.; Di, L.; Chi, J.; Perez, M. C.; Chen, G.-C.; Shen, E. S. Bioorg. Med. Chem. 2006, 14, 5729. crossref(new window)

Balzarini, J.; Orzeszko-Krzesinska, B.; Maurin, J. K.; Orzeszko, A. Eur. J. Med. Chem. 2009, 44, 303. crossref(new window)

Zhou, H.; Wu, S.; Zhai, S.; Liu, A.; Sun, Y.; Li, R.; Zhang, Y.; Ekins, S.; Swaan, P. W.; Fang, B.; Zhang, B.; Yan, B. J. Med. Chem. 2008, 51, 1242. crossref(new window)

Pan. B.; Huang, R.; Zheng, L.; Chen, C.; Han, S.; Qu, D.; Zhu, M.; Wei, P. Eur. J. Med. Chem. 2011, 46, 819. crossref(new window)

Kavitha, C. V. Bioorg. Med. Chem. 2006, 14, 2290. crossref(new window)

Bonde, C. G.; Gaikwad, N. J. Bioorg. Med. Chem. 2004, 12, 2151. crossref(new window)

Bondock, S.; Khalifa, W.; Fadda, A. A. Eur. J. Med. Chem. 2007, 42, 948. crossref(new window)

Bondock, S.; Khalifa, W.; Fadda, A. A. Synth. Commun. 2006, 36, 1601. crossref(new window)

Patel, N. B.; Shaikh, F. M. Saudi Pharm. J. 2010, 18, 129. crossref(new window)

Lingampalle, D.; Jawale, D.; Waghmare, R.; Mane, R. Synth. Commun. 2010, 40(6), 2397. crossref(new window)

Jaju, S.; Palkar, M.; Maddi, V.; Ronad, P.; Mamledesa, S.; Satyanarayana, D. Archiv der Pharmazie 2009, 342(12), 723. crossref(new window)

Lourenco, M. C.da S.; Ferreira, M. de L. M.; Souza, V. N. de; Peralta, M. A.; Vasconcelos, T. R. A.; Henriques, M. das, G. M. O. Eur. J. Med. Chem. 2008, 43(6), 1344. crossref(new window)

Khan, M. H. Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 2007, 46(1), 148.

Thomas, A. B.; Tupe, P. N.; Badhe, R. V.; Nanda, R. K.; Kothapalli, L. P.; Paradkar, O. D.; Sharma, P. A.; Deshpande, A. D. Green Chem. Lett. Rev. 2009, 2, 23. crossref(new window)

Thomas, A. B.; Sharma, P. A.; Nanda, R. K.; Kothapalli, L. P.; Paradkar, O. D.; Deshpande, A. D. Green Chem. Lett. Rev. 2011, 4(3), 211. crossref(new window)

Jorgensen, J. H. In Clinical Microbiology; Tonover, F. C., Ed.; ASM Press: Washington, DC, 1995; p 1275.