Ultrasound Mediated, Sodium Bisulfite Catalyzed, Solvent Free Synthesis of 6-Amino-3-methyl-4-substitued-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Darandale, Sunil N.; Sangshetti, Jaiprakash N.; Shinde, Devanand B.

doi:10.5012/jkcs.2012.56.3.328

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Ultrasound Mediated, Sodium Bisulfite Catalyzed, Solvent Free Synthesis of 6-Amino-3-methyl-4-substitued-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Journal title : Journal of the Korean Chemical Society
Volume 56, Issue 3, 2012, pp.328-333
Publisher : Korean Chemical Society
DOI : 10.5012/jkcs.2012.56.3.328

Title & Authors

Ultrasound Mediated, Sodium Bisulfite Catalyzed, Solvent Free Synthesis of 6-Amino-3-methyl-4-substitued-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
Darandale, Sunil N.; Sangshetti, Jaiprakash N.; Shinde, Devanand B.;

Abstract

A simple, convenient and practical green synthetic protocol for sodium bisulfite catalyzed multicomponent reaction of ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes for the synthesis of 6-amino-4-phenyl-3-methyl-2,4-ihydropyrano[2,3-c]pyrazole-5-carbonitriles using ultrasound irradiations in solvent free condition. This method provides the advantage of operational simplicity, shorter reaction time and excellent yields making the protocol environment friendly and economically lucrative.

Keywords

Pyrano[2,3-c]pyrazole;Substituted aldehydes;Sodium bisulfite catalyst;

Language

English

Cited by

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