JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Synthesis and Antimicrobial Evaluation of Some Novel 2-(4-Chlorophenylimino) thiazolidin-4-one Derivatives
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Synthesis and Antimicrobial Evaluation of Some Novel 2-(4-Chlorophenylimino) thiazolidin-4-one Derivatives
B`Bhatt, H.; Sharma, S.;
  PDF(new window)
 Abstract
A series of 2-(4-chlorophenylimino)-5-((3-(p-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl) methylene) thiazolidin-4-one () compounds were prepared from the 2-(4-chlorophenylimino) thiazolidin-4-one () and 1-phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde (). All compounds were characterized by elemental (C, H, N) analysis and spectral (FT-IR, NMR and GC-MS) analysis. These newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial activity was observed and evaluated against the bacterial strains like Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442) and against the fungal strains like Candida albicans (MTCC 227), Aspergillus niger (MTCC 282) and Aspergillus clavatus (MTCC 1323). All the synthesized compounds were found to possess moderate to excellent antimicrobial activity against above selected strains.
 Keywords
2-(4-Chlorophenylimino) thiazolidin-4-one;Antibacterial activity;Anti fungal activity;Vilsmeier-Haack reaction;Knoevenagel condensation reaction;
 Language
English
 Cited by
1.
Ring Transformation of the S-(2-Oxo-2,3-dihydro-1-benzofuran-3-yl)isothiuronium Bromides to 5-(2-Hydroxyphenyl)-2-imino-1,3-thiazolidin-4-ones, HETEROCYCLES, 2014, 89, 5, 1183  crossref(new windwow)
2.
Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids, European Journal of Medicinal Chemistry, 2016, 113, 145  crossref(new windwow)
 References
1.
Mistry, K. M.; Desai, K. R. E-J. Chem. 2004, 1, 189. crossref(new window)

2.
Gursoy, A.; Terzioglu, N. Turk. J. Chem. 2005, 29, 247.

3.
Knusli, G. E. Chim. Ital. 1949, 79, 621.

4.
Kucukguzel, S. G.; Oruc, E. E.; Rollas, S.; Sahin, F.; Ozbek, A. Eur. J. Med. Chem. 2002, 37, 197. crossref(new window)

5.
Kucukguzel, G.; Kocatepe, A.; Clercq, E. D.; Sahin, F.; Gulluce, M. Eur. J. Med. Chem. 2006, 41, 353. crossref(new window)

6.
Bukowski, L.; Janowiec, M.; Zwolska-Kwiek, Z.; Andrzejczyk, Z. Pharmaz. 1999, 54, 651.

7.
Babaoglu, K.; Page, M. A.; Jones, V. C.; McNeil, M. R.; Dong, C.; Naismith, J. H.; Lee, R. E. Bioorg. Med. Chem. Lett. 2003, 13, 3227. crossref(new window)

8.
Goel, T.; Ram, R.; Tyagi, E.; Bansal, A.; Kumar, D.; Mukherjee, Sinha, J. N. Eur. J. Med. Chem. 1999, 34, 265. crossref(new window)

9.
Vigorita, M. G.; Ottana, R.; Monforte, F.; Maccari, R.; Trovato, A.; Monforte, M.; Taviano, M.F. Bioorg. Med. Chem. Lett. 2001, 11, 2791. crossref(new window)

10.
Bhati, S. K.; Kumar, A. Eur. J. Med. Chem. 2008, 43, 2323. crossref(new window)

11.
Barreca, M. L.; Chimirri, A.; De Luca, L.; Monforte, A. M.; Monforte, P.; Rao, A.; Zappala, M.; Balzarini, J.; De Clercq, E. Bioorg. Med. Chem. Lett. 2001, 11, 1793. crossref(new window)

12.
Murugesan, V.; Prabhakar, Y. S.; Katti, S. B. J. Mol. Graph. Model. 2009, 27, 735. crossref(new window)

13.
Balzarini, J.; Orzeszko-Krzesinska, B.; Maurin, J. K.; Orzesko, A. Eur. J. Med. Chem. 2009, 44, 303. crossref(new window)

14.
Mosula, L.; Zimenkovsky, B.; Havrylyuk, D.; Missir, A. V.; Chirita, I. C.; Lesyk, R. Farmac. 2009, 57, 321.

15.
Jeo, R.; Park, S. Arch. Pharm. Res. 2004, 27, 1099. crossref(new window)

16.
Lesyk, R.; Vladzimirska, O.; Zimenkovsky, B. Boll. Chim. Farmace. 1998, 137, 210.

17.
Amir, M.; Khan, S.; Khan, M. Ind. J. Heterocycl. Chem. 2001, 11, 55.

18.
Jain, R.; Pandya, P.; Bhadauria, J.; Tomar, S. J. Indian. Chem. Soc. 2000, 77, 42.

19.
Gupta, D. P.; Bhadauria, R. S.; Soan, V. Int. J. Pharma. Appl. Sci. 2010, 1, 97.

20.
Sarma, K. N.; Subha, M. C. S.; Rao, K. C. E-J. Chem. 2010, 7, 745. crossref(new window)

21.
Solanki, P. R.; Wadodarkar, K. N. Ind. J. Heterocycl. Chem. 2003, 13, 135.

22.
Jr. Owen, J. E.; Swanson, E. E.; Meyers, D. B. J. Am. Pharm. Assoc. 2006, 47, 70. crossref(new window)

23.
Badawey, E.; El-Ashmawey, I. M. Eur. J. Med. Chem. 1998, 33, 349. crossref(new window)

24.
Makhsumov, A. G.; Dzhuraev, A. D.; Kilichov, G.; Nikbaev A.T. Khimiko-farmatsevticheskii Zhurnal. 1986, 20, 289.

25.
Bekhit, A. A.; Ashour, H. M.; Guemei, A. A. Arch. Pharm. 2005, 338, 167. crossref(new window)

26.
Dominguez, J. N.; Charris, J. E.; Caparelli, M.; Riggione, F. Arzneimittelforschung 2002, 52, 482.

27.
Ouyang, G.; Chen, Z.; Cai, X.; Song, B.; Bhadury, P. S.; Yang, S.; Jin, L.; Xue, W.; Hu, D.; Zeng, S. Bioorg. Med. Chem. 2008, 16, 9699. crossref(new window)

28.
Zhou, H.; Wu, S.; Zhai, S.; Liu, A.; Sun, Y.; Li, R.; Zhang, Y.; Ekins, S.; Swaan, P. W.; Fang, B.; Zhang, B.; Yan, B. J. Med. Chem. 2008, 51, 1242. crossref(new window)

29.
Pier, G. B.; Barbara, C.; Giampiero, S.; Romeo, R.; Giovanni, B.; Abdel, N. Z.; Maria, J.; de las, I. Synthesis 1997, 10, 1140.

30.
Porse, B. T.; Leviev, L.; Mankin, A. S.; Garret, R. A. J. Mol. Biol. 1998, 276, 391. crossref(new window)

31.
Ghalem, B. R.; Mohamed, B. Afr. J. Pharm. Pharmacol. 2009, 3, 92.