Advanced SearchSearch Tips
Preparation and Drug-releasing Properties of Chitosan-based Thermosensitive Composite Hydrogel
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Preparation and Drug-releasing Properties of Chitosan-based Thermosensitive Composite Hydrogel
Li, Heping; Yu, Tao; Li, Shan; Qin, Long; Ning, Jingheng;
  PDF(new window)
The novel chitosan-based thermosensitive hydrogels were prepared as control-releasing drug carriers. N-carboxyethyl chitosan (ACS) was synthesized by microwave heating for 1 h through Michael addition of CS to acrylic acid in a grafting yield of 52.97%, which was proved to be a faster and more efficient way than ordinary methods. 5-Fu was modified with formaldehyde to synthesize N,N`-Bis(hydroxymethyl)-5-fluorouracil (5-Fu-OH). Then an esterification was performed using ACS and 5-Fu-OH to give 5-Fu-ACS. The new thermosensitive hydrogels were prepared by adding sodium glycerophosphate to the solution of compounds under a certain constant temperature. Simultaneously, the hydrogels` swelling rate, in vitro drug release rate and thermosensitive were studied, and found that the 5-Fu-ACS composite hydrogel had more excellent releasing effect, higher drug loading and better thermosensitive.
Chitosan;Acrylic acid;Microwave heating;Thermosensitive hydrogel;Drug releasing;
 Cited by
Carbohydrate polymer based pH-sensitive IPN microgels: Synthesis, characterization and drug release characteristics, Materials Chemistry and Physics, 2017, 195, 176  crossref(new windwow)
Phosphate crosslinked pectin based dual responsive hydrogel networks and nanocomposites: Development, swelling dynamics and drug release characteristics, International Journal of Biological Macromolecules, 2017, 103, 1162  crossref(new windwow)
A comparative study and evaluation of magnetic and nonmagnetic hydrogels towards mitigation of di butyl and di ethyl hexyl phthalate from aqueous solutions, Journal of the Taiwan Institute of Chemical Engineers, 2016, 59, 578  crossref(new windwow)
Kumar, S.; Aninat, C.; Michaux, G.; Morel, F. J. Rep. Toxic. 2010, 29, 415. crossref(new window)

van Kuilenburg, A. B. P. Eur. J. Cancer 2004, 40, 939. crossref(new window)

Alvarenga, E. S.; Oliveiraa, C. P.; Bellatoa, C. R. Carbohydr. Polym. 2010, 80, 1155. crossref(new window)

Tayela, A. A.; Moussaa, S.; Knittelb, O.; Dierk, K.; Schollmeyerb, E.; Nickisch-Hartfiel, A. Int. J. Bio. Mac. 2010, 47, 10. crossref(new window)

Guo, Z. Y.; Xing, R. G.; Liu, S. Carbohydr. Polym. 2008, 73, 173. crossref(new window)

Kandile, N. G.; Mohamed, M. I.; Zaky, H. T.; Nasr, A. S.; Abdel-Bary, E. M. Carbohydr. Polym. 2009, 75, 580. crossref(new window)

Zuniga, A.; Debbaudta, A.; Albertengoa, L.; Rodriguez, M. S.; Carbohydr. Polym. 2010, 79, 475. crossref(new window)

Thanou, K. M. Adv. Drug. Del. Rev. 2010, 21, 3.

Li, R. H.; Cheng, Y. L. Journal of Beijing Union University (Natural Sciences) 2008, 22, 30.

Jiang, T. D. Chitosan; Chemical Industry Press: Beijing, China, 2006.

Fan, T. F.; Li, M. J.; Wu, X. M.; Li, M.; Wu, Y. Colloids and Surf., B: Biointerfaces 2011, 88, 593. crossref(new window)

Wei, L.; Lin, J. P.; Cai, C. H.; Fang, Z. D.; Fu, W. G. Eur. J. Pharm. Biopharm. 2011, 78, 346. crossref(new window)

Zhang, L. Y.; Li, Z. W.; Li, M. L.; Zeng, Q. X. Chem. Ind. Eng. Pro. 2008, 27, 585.

Li, H. P.; Wang, Z. D.; Yu, T. Med. Chem. Res. 2011, 20, 67. crossref(new window)

Chenite, A.; Chaput, C.; Wang, D.; Combes, C.; Buschmann, M. D.; Hoemann, C. D.; Leroux, J. C.; Atkinson, B. L.; Binette, F.; Selmani, A. Biomaterials 2000, 21, 2155. crossref(new window)