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Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones
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 Title & Authors
Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones
Kodhati, Venkateshwarlu; Vanga, Malla Reddy; Yellu, Narsimha Reddy;
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The synthesis of title compounds were accomplished by synthetic sequence shown in Scheme 1. Chalcones on cyclocondensation with thiourea in ethanol and potassium hydroxide under reflux yielded the respective dihydropyramidin-2(1H)-thiones. Each of the dihydropyrimidin thiones was, then subjected to the Mannich condensation in alkaline medium using three different secondary amines, viz., dimethylamine, diethylamine and morpholine to obtain a new series of S-Mannich bases. All the synthesised compounds () were evaluated for their antiulcer and antibacterial activities. Compounds , , , and exhibited relatively more potent antiulcer activity but not comparable to the standard; Omeprazole, while , , and were moderate in activity at 100 mg/kg p.o. All the compounds () showed mild to moderate activity against both Gram-positive (S.aureus, L.delbrueckii) and Gram-negative (P.vulgaris, E.coli) bacteria. Amongst the compounds tested, only , , and were found to be potent.
4, 6-diaryl-3,4-dihydropyramidin-2(1H)-thiones;Anti-ulcer activity;Antibacterial activity;
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