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Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones
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 Title & Authors
Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones
Kodhati, Venkateshwarlu; Vanga, Malla Reddy; Yellu, Narsimha Reddy;
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 Abstract
The synthesis of title compounds were accomplished by synthetic sequence shown in Scheme 1. Chalcones on cyclocondensation with thiourea in ethanol and potassium hydroxide under reflux yielded the respective dihydropyramidin-2(1H)-thiones. Each of the dihydropyrimidin thiones was, then subjected to the Mannich condensation in alkaline medium using three different secondary amines, viz., dimethylamine, diethylamine and morpholine to obtain a new series of S-Mannich bases. All the synthesised compounds () were evaluated for their antiulcer and antibacterial activities. Compounds , , , and exhibited relatively more potent antiulcer activity but not comparable to the standard; Omeprazole, while , , and were moderate in activity at 100 mg/kg p.o. All the compounds () showed mild to moderate activity against both Gram-positive (S.aureus, L.delbrueckii) and Gram-negative (P.vulgaris, E.coli) bacteria. Amongst the compounds tested, only , , and were found to be potent.
 Keywords
4, 6-diaryl-3,4-dihydropyramidin-2(1H)-thiones;Anti-ulcer activity;Antibacterial activity;
 Language
English
 Cited by
1.
Mannich bases in medicinal chemistry and drug design, European Journal of Medicinal Chemistry, 2015, 89, 743  crossref(new windwow)
2.
Biological Evaluations of some Synthesized Pyrimidothieno [2,3-b] Pyrimidine Candidates as Antiulcer Agents, International Journal of Pharmacology, 2015, 11, 7, 840  crossref(new windwow)
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