JOURNAL BROWSE
Search
Advanced SearchSearch Tips
One Pot Synthesis of Bioactive Novel Cyanopyridones
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
One Pot Synthesis of Bioactive Novel Cyanopyridones
Khokhani, Kamlesh; Khatri, Taslimahemad; Patel, Praful;
  PDF(new window)
 Abstract
Cyanopyridone was prepared by the condensation of cyanoacetamide, substituted arylaldehydes and malononitrile in presence of pipyridine. The structure of the synthesized compound CP 1-20 was assigned on the basis of elemental analysis, IR, -NMR and mass spectroscopy. These compounds were also screened for antimicrobial activity. The Minimum Inhibitory Concentration (MIC) of all the synthesized compounds was compared with standard drugs.
 Keywords
Cyanopyrimidones;Cyanoacetamide;Antimicrobial activity;Malononitrile;Pipyridine;
 Language
English
 Cited by
1.
One Pot Synthesis of Novel Cyanopyridones as an Intermediate of Bioactive Pyrido[2,3-d]Pyrimidines,;;

대한화학회지, 2014. vol.58. 4, pp.366-376 crossref(new window)
1.
One Pot Synthesis of Novel Cyanopyridones as an Intermediate of Bioactive Pyrido[2,3-d]Pyrimidines, Journal of the Korean Chemical Society, 2014, 58, 4, 366  crossref(new windwow)
 References
1.
Choi, W.; Houpis, I. N.; Charchil, H. R. O.; Molina, A.; Lynch, J. E.; Volante, R. P.; Reider, P. J.; King, A. O. Tetrahedron 1995, 36, 4571. crossref(new window)

2.
Bhupathy, M.; Conlon, D. A.; Wells, K. M.; Wells, M.; Nolson, J. R.; Reider, P. J.; Rossen, K.; Sager, J. W.; Volante, R. P. Cyanoacetanilides Intermediates in Heterocyclic Synthesis. Part 1: A Facile Synthesis of Polysubstituted and Condensed Pyridones J. Heterocyclic Chem. 1995, 32, 1283. crossref(new window)

3.
Kappe, O. C.; Kappe, T. Synthesis of substituted 3-pyridine carbo nitriles with potential biological activity Monatshefte fur Chemie 1989, 120, 1095. crossref(new window)

4.
Saiki, A. Y. C.; Shen, L. L.; Chen, C. M.; Baranowski, J.; Lerner, C. G. DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones Antimicrob. Agents Chemother. 1999, 43, 1574.

5.
Brickner, S. Regio and Selective Synthesis of 4,6-Disubstituted-2-pyridones. Chem. Ind. 1997, 131.

6.
Cheney, I. W.; Yan, S.; Appleby, T.; Walker, H.; Vo, T.; Yao, N.; Hamatake, R.; Hong, Z.; Wu, J. Z. Bioorg. Med. Chem. Lett. 2007, 17, 1679. crossref(new window)

7.
Wendt, M. D.; et al. Bioorg. Med. Chem. Lett. 2007, 17, 3122. crossref(new window)

8.
Hardie, D. G. Endocrinology 2003, 144, 5179. crossref(new window)

9.
Hardie, D. G.; Scott, J. W.; Pan, D. A.; Hudson, E. R. FEBS Lett. 2003, 546, 113. crossref(new window)

10.
Kahn, B. B.; Alquier, T.; Carling, D.; Hardie, D. G. Cell Metab. 2005, 1, 15. crossref(new window)

11.
Hawley, S. A.; Boudeau, J.; Reid, J. L.; Mustard, K. J.; Udd, L.; Makela, T. P.; Alessi, D. R.; Hardie, D. G. J. Biol. 2003, 2, 28. crossref(new window)

12.
Li, Q.; Mitscher, L. A.; Shen, L. L. The 2-Pyridone Antibacterial Agents: Bacterial Topoisomerase Inhibitors Med. Res. Rev. 2000, 20, 231. crossref(new window)

13.
Gupta, A, K.; Plott, T. Ciclopirox: A Broad-Spectrum Antifungal with Antibacterial and Anti-inflammatory Properties. Int. J. Dermatol. 2004, 43, 3. crossref(new window)

14.
Collins, I.; et al. 3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for $\alpha2$/$\alpha3$-Subtypes of Human GABAA Receptor-Ion Channels J. Med. Chem. 2002, 45, 1887. crossref(new window)

15.
Robert, N.; Verrier, C.; Hoarau, C.; Celanire, S.; Marsais, F. Solid-phase Synthesis of 3-Hydroxy-2-methylenealkanenitriles Using Polymer-Supported $\alpha$-Selenopropionitrile. ARKIVOC 2008, 7, 92.

16.
Sollogoub, M.; Fox, K. R.; Powers, V. E. C.; Brown, T. First Synthesis of 1-Deazacytidine, the C-nucleoside Analogue of Cytidine Tetrahedron Lett. 2002, 43, 3121. crossref(new window)

17.
Parsons, S.; Winpenny, R. E. P. Structural Chemistry of Pyridonate Complexes of Late 3d-Metals Acc. Chem. Res. 1997, 30, 89. crossref(new window)

18.
Murray, T.; Zimmerman, S. 7-Amido-1,8-naphthyridines as Hydrogen Bonding Units for the Complexation of Guanine Derivatives: The Role of 2-Alkoxyl Groups in Decreasing Binding Affinity Tetrahedron Lett. 1995, 36, 7627. crossref(new window)

19.
Werbitzky, O.; Studer, P. Process for the Production of 2-Chloro-5-chloromethyl-pyridine. U.S. Patent 6,022,974, Feb 8, 2008.

20.
Murata, T.; Shimizu, K.; Narita, M.; Manganiello, V.; Tagawa, T. Characterization of Phosphodiesterase 3 in Human Malignant Melanoma Cell Line Anticancer Res. 2000, 22, 3171.

21.
Ahmed Ali, F.; Samir, B.; Ramy, R.; Hassan Ali, E. Cyanoacetamide Derivatives as Synthons in Heterocyclic Synthesis Turk. J. Chem. 2008, 32, 259.

22.
National Committee for Clinical and Laboratory Standards (NCCLS). Method for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, 4th ed. NCCLS, Villanova, Italy. 1997, Document M 100-S7. S100-S157.

23.
Isenberg, D. H. Essential Procedure for Clinical Microbiology; American Society for Microbiology: Washington, 1998.

24.
Zgoda, J. R.; Porter, J. R. Pharm. Biol. 2001, 39, 221-25. crossref(new window)