JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Ultrasound-Triggered Drug Release of Hydroxyapatite Coated Liposomes
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Ultrasound-Triggered Drug Release of Hydroxyapatite Coated Liposomes
Cho, Sung Keun; Wee, Tae In; Ha, Jeung; Cho, Sun Hang; Han, Kun; Han, Hee Dong; Shin, Byung Cheol;
  PDF(new window)
 Abstract
Liposomes, which can deliver payload at target site, have been studied as drug carrier. However, conventional liposomes have limitation for drug release at target site. Therefore, we developed hydroxyapatite (HA) coated ultrasound sensitive liposomes to increase drug release at target site and to enhance stability in blood stream. Control liposome was prepared using hydrogenated soy phosphatidylcholine (HSPC) and cholesterol, and then we assessed HA coating on the surface of control liposomes using calcium acetate, phosphoric acid, and 25% ammonium solution. Doxorubicin was used as a model drug. Size of HA coated liposomes was 120 nm and encapsulation efficiency of doxorubicin in liposomes was up to 95%. Size of HA coated liposomes are not changed in 30% serum solution, however, the control liposomes was 1.4 fold increased. After ultrasound triggered drug release from liposomes, intracellular efficiency of drug released from HA coated liposomes was 3 fold increased compared to control liposomes. In this study, we developed ultrasound sensitive liposomes to enhance drug release, which will be applied in controlled drug release at disease site.
 Keywords
Hydroxyapatite;Liposome;Ultrasound;Drug release;Stability;
 Language
English
 Cited by
1.
Enhanced Stability of Hydroxyapatite-coated Liposomes for Ultrasound-triggered Drug Release,;;;;;;

Bulletin of the Korean Chemical Society, 2015. vol.36. 1, pp.83-87 crossref(new window)
1.
Enhanced Stability of Hydroxyapatite-coated Liposomes for Ultrasound-triggered Drug Release, Bulletin of the Korean Chemical Society, 2015, 36, 1, 83  crossref(new windwow)
 References
1.
Torchilin, V. P. Nat. Rev. Drug Discov. 2005, 4, 145. crossref(new window)

2.
Han, H. D.; Shin, B. C.; Choi, H. S. Eur. J. Pharm. Biopharm. 2006, 62, 110. crossref(new window)

3.
XueMing, Li.; LiYan, Ding.; Yuanlong, Xu.; Yonglu, Wang.; QiNeng, Ping. Int. J. Pharm. 2009, 373, 116. crossref(new window)

4.
Moghimi, S. M.; Szebeni, J. Prog. Lipid Res. 2003, 42, 463. crossref(new window)

5.
Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. J. Control. Release 2000, 65, 271. crossref(new window)

6.
Muhlen, A. Z.; Schwarz, C.; Mehnert, W. Eur. J. Pharm Biopharm. 1998, 45, 149. crossref(new window)

7.
Paoli, E. E.; Kruse, D. E.; Seo, J. W.; Zhang, H.; Kheirolomoom, A.; Watson, K. D.; Chiu, P.; Stahlberg, H.; Ferrara, K. W. J. Control. Release 2010, 143, 13. crossref(new window)

8.
Gopal, R.; Anyarambhatla.; David, Needham. J. Liposome Res. 1999, 9, 491. crossref(new window)

9.
Simoes, S.; Moreira, J. N.; Fonseca, C.; Duzgune , N.; de Lima, M. C. Adv. Drug Delivery Rev. 2004, 56, 947. crossref(new window)

10.
Zhang R. S.; Tang, M. G.; Bowyer, A.; Eisenthal, R.; Hubble, J. Biomaterials 2005, 26, 4677. crossref(new window)

11.
Angelatos, A. S.; Radt, B.; Caruso, F. J. Phys. Chem B 2005, 109, 3071. crossref(new window)

12.
Kulkarni, R. V.; Biswanath, S. J. Appl. Biomater. Biomech. 2007, 5, 125.

13.
Liu, C. Y.; Guo, J.; Yang, W. L.; Hu, J. H.; Wang, C. C.; Fu, S. K. J. Mater. Chem. 2009, 19, 4764. crossref(new window)

14.
Huang, S. L. Adv. Drug. Delivery Rev. 2008, 60, 1167. crossref(new window)

15.
Liu, Y. Y.; Miyoshi, H.; Nakamura, M. J. Control. Release 2006, 114, 89. crossref(new window)

16.
Liu, Y.; Yang, H.; Sakanishi, A. Biotechnol. Adv. 2006, 24, 1. crossref(new window)

17.
Xu, Q.; Tanaka, Y.; Czernuszka, J. T. Biomaterials 2007, 28, 2687. crossref(new window)

18.
Rose, F.; Hou, Q. P.; Oreffo, R. O. C. J. Pharm. Pharmacol. 2004, 56, 415. crossref(new window)

19.
Bohmer, M. R.; Klibanov, A. L.; Tiemann, K.; Hall, C. S.; Gruell, H.; Steinbach, O. C. Eur. J. Radiol. 2009, 70, 242. crossref(new window)

20.
Schroeder, A.; Honen, R.; Turjeman, K.; Gabizon, A.; Kost, J.; Barenholz Y. J. Control. Release 2009, 137, 63. crossref(new window)

21.
Fritze, A.; Hens, F.; Kimpfler, A.; Schubert, R.; PeschkaSuss, R. Biochim. Biophys. Acta 2006, 1758, 1633. crossref(new window)

22.
Liu, T. Y.; Huang, T. C. Acta Biomater. 2011, 7, 3927. crossref(new window)