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Synthesis, Characterization and Antimicrobial Activity of Bifunctional Sulfonamide-Amide Derivatives
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 Title & Authors
Synthesis, Characterization and Antimicrobial Activity of Bifunctional Sulfonamide-Amide Derivatives
Abbavaram, Babul Reddy A.; Reddyvari, Hymavathi R.V.;
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 Abstract
A convenient synthesis of bifunctional sulfonamide-amide derivatives was reported. Amide coupling of 4-methyl benzoic acid 1 followed by reaction with chlorosulfonic acid produce ethyl-4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine-1-carboxylate 4. The resulted compound on further treatment with various anilines produces the title sulfonamide-amide derivatives 5a-n. The configurations of these compounds were established by elemental analysis, IR, NMR, mass spectra, and by their preparation from the corresponding 4-methyl benzoic acid 1 and chlorosulfonic acid. All these new compounds demonstrate significant in vitro antibacterial and antifungal activities against all bacterial and fungal strains.
 Keywords
Sulfonamide-amide;4-Methyl benzoic acid;Chlorosulfonic;Antibacterial and antifungal activities;
 Language
English
 Cited by
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