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Synthesis and Pharmacological Evaluation of Some Novel 2-Mercapto Benzimidazole Derivatives
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 Title & Authors
Synthesis and Pharmacological Evaluation of Some Novel 2-Mercapto Benzimidazole Derivatives
Nevade, Sidram A.; Lokapure, Sachin G.; Kalyane, Navanath V.;
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 Abstract
The present study is synthesis of derivatives of N`-(4-amino-5-sulfanyl-4H-1,2,4-triazole-3-yl)-2-(1H-benzimidazole-2-ylsulfanyl) acetohydrazide (IV). Antibacterial activity tested against the E. coli and A. Substilis. Biological activities conducted by disc diffusion method. Compound , , inhibit the appreciable microbial growth while rest of the compound possess the moderate activities. Anti-inflammatory activity tested by reduces local edema induced in the rat paw by injection of phlogestic agent. Compound , , , and exhibit satisfying anti-inflammatory activity while analgesic activity conducted by acetic acid induced writhing effect in mice while compound , and having the good analgesic activity. The chemical structures of all newly synthesized compounds were confirmed by their IR, NMR and mass spectral data.
 Keywords
2-Mercaptobenzimidazole;Dimethyl sulfoxide;Anti-inflammatory;Analgesic and antibacterial activity;
 Language
English
 Cited by
1.
Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine, Archiv der Pharmazie, 2016, 349, 7, 475  crossref(new windwow)
2.
Alkylation and Aminomethylation of 1,3-Dihydro-2Н-Benzimidazole-2-Thione, Chemistry of Heterocyclic Compounds, 2015, 50, 11, 1547  crossref(new windwow)
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