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Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives
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 Title & Authors
Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives
Mhaske, Pravin C.; Shelke, Shivaji H.; Raundal, Hemant N.; Jadhav, Rahul P.;
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 Abstract
In the present study a novel series of (2-substituted-4-methylthiazol-5-yl)(4-substituted piperazin-1-yl)methanone derivatives were synthesized by reaction of 2-substituted-4-methylthiazole-5-carboxylic acid with N-substituted benzyl piperazine by using 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDCl) and 1-hydroxybenzotriazole (HOBt) in DMF. All the newly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro antibacterial activity. Most of the compounds show moderate to good antimicrobial activity.
 Keywords
Thiazole;Piperazine;EDCl-HOBt;Antimicrobial activity;
 Language
English
 Cited by
 References
1.
Hutchinson, I.; Jennings, S. A.; Vishnuvajjala, B. R.; Westwell, A. D.; Stevens, M. F. G. J. Med. Chem. 2002,45, 744. crossref(new window)

2.
Nicolaou, K. C.; Roschanger, F.; Vourloumis, D. Angew. Chem. Int. Ed. 1998, 37, 2014. crossref(new window)

3.
Ojika, M.; Suzuki, Y.; Tsukamoto, A.; Sakagami, Y.; Fudou, R.; Yoshimura, T.; Yamanaka, S. J. Antibiot. 1998, 51, 275. crossref(new window)

4.
Suzuki, Y.; Ojika, M.; Sakagami, Y.; Fudou, R.; Yamanaka, S. Tetrahedron 1998, 54, 11399. crossref(new window)

5.
EI-Subbagh, H. I.; Al-Obaid, A.M. Eur. J. Med. Chem. 1996, 31, 1017. crossref(new window)

6.
Zhang, C.; Zink, D. L.; Ushio, M.; Burgess, B.; Onishi, R.; Masurekar, P.; Barrett, J. F.; Singh, S. B. Bioorg. Med. Chem. 2008, 16, 8818. crossref(new window)

7.
Kalkhambkar, R. G.; Kulkarni, G. M.; Shivkumar, H.; Rao, N. R. Eur. J. Med. Chem. 2007, 42, 1272. crossref(new window)

8.
Franklin, P. X.; Pillai, A. D.; Rathod, P. D.; Yerande, S.; Nivsarkar, M.; Padh, K. K.; Sudarsanam, V. Eur. J. Med. Chem. 2008, 43, 129. crossref(new window)

9.
Zitouni, G. T.; Ozdemir, A.; Kaplancikli, Z. A.; Benkli, K.; Chevallet, P.; Akalin, G. Eur. J. Med. Chem. 2008, 43,981. crossref(new window)

10.
Bekhit, A. A.; Ashour, H. M. A.; Abdel Ghany, Y. S.; Bekhit, A. E. A.; Baraka, A. Eur. J. Med. Chem. 2008, 43, 456. crossref(new window)

11.
Karegoudar, P.; Karthikeyan, M. S.; Prasad, D. J.; Mahalinga, M.; Holla, B. S.; Kumari, N. S. Eur. J. Med. Chem. 2008, 43, 261. crossref(new window)

12.
Verma, A.; Saraf, S. K. Eur. J. Med. Chem. 2008, 43, 897. crossref(new window)

13.
Kumar, A.; Rajput, C. S. Eur. J. Med. Chem. 2009, 44, 83. crossref(new window)

14.
Misturu, O.; Atsushi, K.; Hiroyoshi, S.; Hisashi, T. Chem. Pharma Bull. 1995, 43, 947. crossref(new window)

15.
Kim, J. Y.; Seo, H. J.; Lee, S.-H.; Jung, M. E.; Ahn, K. W.; Kim, J. M.; Lee, J. H. Bioorg. Med. Chem. Lett. 2009, 19,142. crossref(new window)

16.
Sidique, S.; Ardecky, R.; Su, Y.; Narisawa, S.; Brown, B.; Millan, J. L.; Sergienko, E.; Cosford, N. D. P. Bioorg. Med. Chem. Lett. 2009, 19, 222. crossref(new window)

17.
Collins, H. A.; Microbiological Methods, 2nd ed; Butterworth: London, 1976.

18.
Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically NCCLS Approval Standards, Wayne, PA, USA, 2003.

19.
NCCLS Approval Standard Document M2-A7, National Committee for Clinical Laboratory Standards, Vilanova, PA, USA, 2000.