Stimuli-Sensitive Poly(NIPA-co-APA) Hydrogels for the Controlled Release of Keterolac Tromethamine

Kim, Yonghyun; Babu, V. Ramesh; Rao, K.S.V. Krishna; Lim, Jae-Min; Thangadurai, T. Daniel; Lee, Yong-Ill

doi:10.5012/jkcs.2014.58.1.92

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Stimuli-Sensitive Poly(NIPA-co-APA) Hydrogels for the Controlled Release of Keterolac Tromethamine

Journal title : Journal of the Korean Chemical Society
Volume 58, Issue 1, 2014, pp.92-99
Publisher : Korean Chemical Society
DOI : 10.5012/jkcs.2014.58.1.92

Title & Authors

Stimuli-Sensitive Poly(NIPA-co-APA) Hydrogels for the Controlled Release of Keterolac Tromethamine
Kim, Yonghyun; Babu, V. Ramesh; Rao, K.S.V. Krishna; Lim, Jae-Min; Thangadurai, T. Daniel; Lee, Yong-Ill;

Abstract

The pH sensitive hydrogels composed of N-isopropylacrylamide (NIPA) and acryloyl phenylalanine (APA) were prepared by redox polymerization using N,N`-methylenebisacrylamide (MBA) as a crosslinker. Anti-inflammatory and analgesic agent, Keterolac Tromethamine (KT), was loaded successfully into poly(NIPA-co-APA) copolymeric hydrogels by swelling equilibrium method. To understand the nature of drug in the polymeric matrix, the newly synthesized drug loaded poly(NIPA-co-APA) copolymeric hydrogels were characterized by using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques. The scanning electron microscopy (SEM) technique result indicates the spherical smooth surface of the hydrogels. The drug (KT) releasing nature of the poly(NIPA-co-APA) hydrogels was studied in pH 1.2 and 7.4. Effects of drug loading, crosslinking agent, pH and the ionic strength of the external medium on swelling of hydrogels were also investigated.

Keywords

Hydrogel;Keterolac tromethamine;Controlled Release;Stimuli-responsive;

Language

English

Cited by

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