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One-Pot and Green Procedure for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using ZnO Nanoparticles as a Solid Acid Catalyst
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 Title & Authors
One-Pot and Green Procedure for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using ZnO Nanoparticles as a Solid Acid Catalyst
Hassanpour, Akbar; Abolhasani, Jafar; Khanmiri, Rahim Hosseinzadeh;
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 Abstract
A convenient and efficient method has been developed for the one-pot synthesis of dihydropyrimidinones (DHPMs) compounds. Dihydropyrimidinone derivatives were synthesized in good yields using ethyl acetoacetate, aldehyde (aromatic and aliphatic) and urea or thiourea in the presence of ZnO nanoparticles as a catalyst in as solvent at . This green chemistry procedure applied to the Biginelli reaction using ZnO nanoparticles as catalyst and illustrated as a rapid preparation of DHPMs in water as solvent. The products were identified by physical data (mp) by comparison with those reported in the literatures.
 Keywords
Biginelli reaction;Multicomponent reaction;ZnO nanoparticles;Dihydropyrimidinone;
 Language
English
 Cited by
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Green and recyclable sulfonated graphene and graphene oxide nanosheet catalysts for the syntheses of 3,4-dihydropyrimidinones, Monatshefte für Chemie - Chemical Monthly, 2017, 148, 2, 321  crossref(new windwow)
2.
Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction, New J. Chem., 2016, 40, 12, 10412  crossref(new windwow)
3.
A reactant promoted solvent free synthesis of 3,4-dihydropyrimidin-2(1 H )-thione analogues using ammonium thiocyanate, Tetrahedron Letters, 2017, 58, 18, 1778  crossref(new windwow)
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