JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Synthesis and Characterization of Novel Oxadiazole Derivatives from Benzimidazole
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Synthesis and Characterization of Novel Oxadiazole Derivatives from Benzimidazole
Vishwanathan, Balasubramanaya; Gurupadayya, Bannimath;
  PDF(new window)
 Abstract
In the present study, a series of novel N-(1H-benzo[d]imidazol-2-yl)methyl-5-[(hetero)aryl-1,3,4-oxadiazol-2-yl]methanamine (4a-4j) were efficiently synthesized. Condensation of hydrazide derivative 3 with various carboxylic acid derivatives yielded N-[(1H-benzo[d]imidazol-2-yl)methy](5-substituted-1,3,4-oxadiazol-2-yl)methanamine (4a-4j) and compound 5-{[(1H-benzo[d]imidazol-2-yl)methylamino]methyl}-1,3,4-oxadiazole-2-thiol (4k) was obtained on treating hydrazide 3 with carbon disulfide. All the newly synthesized analogues were characterized by IR, NMR, NMR and mass spectral data.
 Keywords
Benzimidazole;Oxadiazole;
 Language
English
 Cited by
 References
1.
Cramer, R. D.; Patterson, D. E.; Bunce, J. D. J. Am. Chem. Soc. 1988, 110, 5959. crossref(new window)

2.
Subudhi, B. B.; Panda, P. K.; Kundu, T.; Sahoo, S.; Pradhan, D. J. Pharm. Res. 2007, 6, 114.

3.
Afaf, H. E.; Fanmy, H. H.; Abdelwad, S. H. Molecules 2000, 5, 1429. crossref(new window)

4.
Ozden, S.; Karatas, H.; Yildiz, S.; Goker, H. Arch. Pharm. Chem. Life Sci. 2004, 337, 556. crossref(new window)

5.
Tebbe, M. J.; Spitzer, W. A.; Victor, F.; Miller, S. C.; Lee, C. C.; Sattelberg, T. R.; McKinney, E.; Tang, J. C. J. Med. Chem. 1997, 40, 3937. crossref(new window)

6.
Migawa, M. T.; Girardet, J. L.; Walker, J. A.; Koszalka, G. W.; Chamberlain, S. D.; Drach, J. C.; Townsend, L. B. J. Med. Chem. 1998, 41, 1242. crossref(new window)

7.
Sidwell, R. W.; Huffman, J. H. Appl. Microbiol. 1971, 22, 797.

8.
Hayden, F. G.; Gwaltney, J. M. Antimicrob. Agents Chemother. 1982, 21, 892. crossref(new window)

9.
Tamm, I.; Sehgal, P. B. Adv. Virus. Res. 1978, 22, 187. crossref(new window)

10.
Aydin, S.; Beis, K.; Can, D. D. Pharmazie 2003, 58, 405.

11.
Bhat, A. K.; Karadiya, H.; Parmer, M. R. Ind. J. Het. Chem. 2003, 13, 187.

12.
Kumar, V. R.; Vaidya, S. D.; Kumar, B. V. S.; Bhise, U. N.; Bhirud, S. B.; Mashelkar, U. C. Eur. J. Med. Chem. 2008, 43, 986. crossref(new window)

13.
Kumar, B. V. S.; Vaidya, S. D.; Kumar, V. R.; Bhirud, S. B.; Mane, R. B. Eur. J. Med. Chem. 2006, 41, 599. crossref(new window)

14.
Goker, H.; Ozden, S.; Yildiz, S.; Boykin, D. W. Eur. J. Med. Chem. 2005, 40, 1062. crossref(new window)

15.
Padmavathi, V.; Reddy, G. S.; Padmaja, A.; Kondaiah, P.; Shazia, A. Eur. J. Med. Chem. 2009, 44, 2106. crossref(new window)

16.
El-Emam, A. A.; Al-Deeb, O. A.; Al-Omar, M. A.; Lehmann, J. Bioorg. Med. Chem. 2004, 12, 5107. crossref(new window)

17.
Kadi, A. A.; El-Brollosy, N. R.; Al-Deeb, O. A.; Habib, E. E.; Ibrahim, T. M.; El-Emam, A. A. Eur. J. Med. Chem. 2007, 42, 235. crossref(new window)

18.
Ali, M. A.; Yar, M. S.; Bioorg. Med. Chem. Lett. 2007, 17, 3314. crossref(new window)

19.
Ladva, K.; Patel, P.; Upadhyay, P.; Parekh, H. Ind. J. Chem. 1996, 35, 1062.

20.
Sahin, G.; Palaska, E.; Ekizoglu, M.; Ozalp, M. Farmaco II. 2002, 57, 539. crossref(new window)

21.
Amir, M.; Javed, S. A.; Kumar, H. Ind. J. Chem. 2007, 46, 1014.

22.
Wagle, S.; Adhikari, A. V.; Kumari, N. S. Ind. J. Chem. 2008, 47, 439.

23.
Najer, H.; Giudicelli, R.; Moral, C.; Menin, M. Bull. Soc. Chem. France 1996, 153.

24.
Almasirad, A.; Tabatabai, S. A.; Faizi, M.; Kebriaceezadeh, A.; Mehrabi, N.; Dalvandi, A.; Shafiee, A. Bioorg. Med. Chem. Lett. 2004, 14, 6057. crossref(new window)

25.
Zarghi, A.; Tabatabai, S. A.; Faizi, M.; Ahadian, A.; Navabi, P.; Zanganeh, V. A. Bioorg. Med. Chem. Lett. 2005, 15, 1863. crossref(new window)

26.
Burbuliene, M. M.; Jakubkiene, V.; Mekuskeine, G.; Vdrenaite, E.; Smicius, R.; Vainilavicius, P. Farmaco II. 2004, 59, 767. crossref(new window)

27.
Sengupta, P.; Dash, D. K.; Yeligar, C. V.; Murugesh, K.; Rajalingam, D.; Singh, J.; Maity, T. K. Ind. J. Chem. 2008, 47, 460.

28.
Yale, H. I.; Losee, K. J. Med. Chem. 1996, 9, 478.

29.
Vu, C. B.; et al. J. Med. Chem. 1999, 42, 4088. crossref(new window)