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Diastereoselective Reduction of 2,3-Dioxo-4-carboxy-5-substituted Pyrrolidines Using NaBH4/AcOH and Heterogenous Hydrogenation Reactions
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 Title & Authors
Diastereoselective Reduction of 2,3-Dioxo-4-carboxy-5-substituted Pyrrolidines Using NaBH4/AcOH and Heterogenous Hydrogenation Reactions
Mohammat, Mohd Fazli; Mansor, Nurul Shulehaf; Shaameri, Zurina; Hamzah, Ahmad Sazali;
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 Abstract
Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidine 1 by and heterogenous hydrogenation were reported. Stereochemical assignment and diastereomeric ratios of the products were determined using NMR and single crystal X-ray analyses. The steric factors of the C-5 substituents of the pyrrolidinone was shown to have an interesting influence on both the yield and diastereoselectivity of the reduced product.
 Keywords
2,3-Dioxo-pyrrolidine;Diastereoselective;Enol reduction;
 Language
English
 Cited by
1.
NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462, Scientific Reports, 2017, 7, 1  crossref(new windwow)
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