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Preparation of Positively and Negatively Charged Carbon Nanotube-Collagen Hydrogels with pH Sensitive Characteristic
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 Title & Authors
Preparation of Positively and Negatively Charged Carbon Nanotube-Collagen Hydrogels with pH Sensitive Characteristic
Seo, Jae-Won; Shin, Ueon Sang;
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 Abstract
In this study, preparation of positively and negatively charged carbon nanotube (CNT)-collagen (CG) hydrogels with pH sensitive characteristic was reported. The positive and negative characteristics of the prepared hydrogels were created by introduction of positively functionalized CNT-NH2 and negatively functionalized CNT-COOH, respectively, into the collagen hydrogel. The surface charge of CNTs (CNT-NH2 and CNT-COOH), CG and CNTs/CG hydrogels was measured by Zetasizer. The swelling ratios of CNT-NH2/CG and CNT-COOH/CG hydrogels in aqueous solution were checked by measuring of weight changes of the hydrogels in the range of pH 2~10. In detail, the positively charged CNT-NH2/CG hydrogel swelled up to 5% at pH 4 in comparison to the weight at pH 7, while the negatively charged CNT-COOH/CG hydrogel swelled up to 10% at pH 10. The prepared CNT-NH2/CG and CNT-COOH/CG hydrogels will be very useful as pH sensitive oral drug-delivering systems for gastrointestine (pH ~2) and small intestine (pH ~9), respectively.
 Keywords
Oral drug carrier;pH sensitive;Collagen;CNTs;Hydrogel;
 Language
Korean
 Cited by
 References
1.
Chugh, I.; Seth, N.; Rana, A. C.; Gupta, S. International Research Journal of Pharmacy 2012, 5, 57.

2.
Bhagwat, R. R.; Vaidhya, I. S. International Research Journal of Pharmacy Science and Research 2013, 4, 970.

3.
Vinay, K.; Prajapati, S. K.; Girish, C. S.; Mahendra, S.; Neerajkumar. World Journal of Pharmacy and Pharmaceutical Sciences 2012, 1, 934.

4.
Balamuralidhara, V.; Pramodkumar, T. M.; Srujana, N.; Venkatesh, M. P.; Gupta, N. V.; Krishana, K. L.; Ganagadharappa, H. V. American Journal of Drug Discovery and Development 2011, 1, 24. crossref(new window)

5.
Michael, C. K.; Joseph, F. G.; Malvika, G.; Annie , Z.; Nicholas, A. P. Journal of Controlled Release 2016, 221, 18. crossref(new window)

6.
Mohamed, S. M. E.; Elbadawy, A. K.; Mamdouh, A. S.; Smaher, M. E. Arabian Journal of Chemistry 2015, 8, 355. crossref(new window)

7.
Yu, C. Y.; Ling, Y. D.; Kai, D.; Wei, X.; Yan, Y.; Lu, Z.; Ke, W.; Feng, J. X. Carbohydrate Polymers 2015, 130, 243. crossref(new window)

8.
Nannan, G.; Shaoyu, L.; Chunmei, G.; Xinggang, W.; Xiubin, X.; Xiao, B.; Chen, F.; Mingzhu, L. Chemical Engineering Journal 2016, 287, 20. crossref(new window)

9.
Dong, M.; Jiantao, L.; Yuyun, C.; Wei, X.; Li, M. Z. Carbon 2012, 50, 3001. crossref(new window)

10.
Mara, G.; Priscilla, F.; Dina, M.; João, R.; Xue, Q.; Changsheng, L.; Helena, T.; Yulin, L. Acta Biomaterialia 2014, 10, 300. crossref(new window)

11.
Cho, E. J.; Sun, B.; Doh, K. O.; Wilson, E. M.; Torregrosa-Allen, S.; Elzey, B. D.; Yeo, Y. Biomaterial 2015, 37, 312. crossref(new window)

12.
Kraemer, J.; Ludwig, J.; Bickert, U.; Owczarek, V.; Traupe, M. Ideas And Technical Innovations 1997, 6, 357.

13.
Lofthouse, S.; Nagahara, S.; Sedgmen, B.; Barcham, G.; Brandon, M.; Sano, A. Vaccine 2001, 19, 4318. crossref(new window)

14.
Hicks, B. G.; Lopez, E. A.; Eastman Jr., R.; Simonovsky, F. I.; Ratner, B. D.; Wessells, H.; Voelzke, B. B.; Bassuk, J. A. Biomaterials 2011, 32, 797. crossref(new window)

15.
Xanthippi, C.; Rameshwar, R. R.; David, J. C.; Alexis, W. P.; Blake, M. A.; Yuan, Y. W.; Li, Z.; Fenno, J. C. F.; Jan, P. S.; Petros, P. Journal of Non-Crystalline Solids 2016, 432, 143. crossref(new window)

16.
Tsai, M. C.; Hung, K. C.; Hung, S. C.; Hsu, S. Colloids and Surfaces B: Biointerfaces 2015, 125, 34. crossref(new window)

17.
Pourjavadi, A.; Ayyari, M.; Amini-Fazl, M. S. European Polymer Journal 2008, 44, 1209. crossref(new window)

18.
Isabelle, B.; Marek, K.; Sylvie, R.; Bhuvanesh, G.; Jons, H.; Florian, W.; Peter, F. Biomaterials 2002, 23, 3149. crossref(new window)

19.
Pinto, V. C.; Ramos, T.; Alves, S.; Xavier, J.; Tavares, P.; Moreira, P. M. G. P.; Guedesa, R. M. Procedia Engineering 2015, 114, 635. crossref(new window)

20.
Yoon, I. K.; Hwang, J. Y.; Seo, J. W.; Jang, W. C.; Kim, H. W.; Shin, U. S. Carbon 2014, 77, 379. crossref(new window)