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The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats
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  • Journal title : Applied Microscopy
  • Volume 43, Issue 2,  2013, pp.54-64
  • Publisher : Korean Society of Electron Microscopy
  • DOI : 10.9729/AM.2013.43.2.54
 Title & Authors
The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats
Lee, Yoon Jeong; Jeune, Kyung Hee;
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The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, -cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues were also vividly recorded. In the STZ+rutin administered group, the heart and retina tissues were shown to be preserved normally while the liver and kidney tissues showed reduced histopathology in general compared to the STZ-treated group. Conclusionally, the rutin has the effect on the antioxidant activities and anti-inflammation in the STZ-induced diabetic rats.
Rutin;Diabetic rats;Streptozocin;Antioxidant;Anti-inflammation;
 Cited by
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