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Effects of Alternate Treatment of Estrogen Receptor Antagonist and Agonist on Morphology of Male Reproductive Organs of Adult Mice
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  • Journal title : Applied Microscopy
  • Volume 43, Issue 3,  2013, pp.103-109
  • Publisher : Korean Society of Electron Microscopy
  • DOI : 10.9729/AM.2013.43.3.103
 Title & Authors
Effects of Alternate Treatment of Estrogen Receptor Antagonist and Agonist on Morphology of Male Reproductive Organs of Adult Mice
Choi, Hayana; Seong, Chi Nam; Park, Mi Suk; Cho, Hyun Wook;
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 Abstract
ICI 182,780 (ICI) is known as an estrogen receptor antagonist, whereas propyl pyrazole triol (PPT) is an estrogen receptor agonist. In this study, ICI or ICI added with PPT was injected into adult male mice. Body and reproductive organ weights were reduced in the ICI added with PPT group compared to the control group. Further, the ICI and ICI added with PPT groups both showed increases in luminal areas of the seminiferous tubules of the testis, whereas cell heights of efferent ductules and the initial segment of the epididymis were reduced. Sperm count in the caudal epididymis was reduced in the ICI and ICI added with PPT groups. These results show that reproductive tissues were more deeply affected in the ICI added with PPT group. We also demonstrated that treatment with ICI resulted in histological changes in the testis, efferent ductule, and epididymis. Further, alternate treatment with ICI and PPT induced abnormalities in reproductive organs. These results indicate that a high concentration of PPT together with ICI may cause histological abnormalities instead of histological restoration in reproductive organs.
 Keywords
Estrogen receptor agonist;Antagonist;Testis;Efferent ductule;Epididymis;
 Language
English
 Cited by
1.
Effects of Short-Term Treatment with Estrogen Receptor Agonist on Morphological Changes in Reproductive Organs of Adult Male Mice,;;;;;;

Applied Microscopy, 2016. vol.46. 4, pp.193-200 crossref(new window)
1.
Disruption of estrogen receptor signaling and similar pathways in the efferent ductules and initial segment of the epididymis, Spermatogenesis, 2014, 4, 2, e979103  crossref(new windwow)
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