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Effect of Pycnogenol on Skin Wound Healing
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  • Journal title : Applied Microscopy
  • Volume 43, Issue 4,  2013, pp.133-139
  • Publisher : Korean Society of Electron Microscopy
  • DOI : 10.9729/AM.2013.43.4.133
 Title & Authors
Effect of Pycnogenol on Skin Wound Healing
Jeong, Moon-Jin; Jeong, Soon-Jeong; Lee, Soo-Han; Kim, Young-Soo; Choi, Baik-Dong; Kim, Seung-Hyun; Go, Ara; Kim, Se Eun; Kang, Seong-Soo; Moon, Chang-Jong; Kim, Jong-Choon; Kim, Sung-Ho; Bae, Chun-Sik;
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This study was carried out to investigate the effects of pycnogenol (PYC) on the cutaneous wound healing of the mice. The wounds were extracted on days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area, infiltrating inflammatory cells, wound contracture including collagen deposition. As the result, the wound area of PYC-treated group was larger than the control group on days 1 to 7. Inflammatory cells in the PYC-treated wounds were decreased at day 1 compared to the control wound tissue. From day 3 to 7, there was no significant difference between the control and the PYC-treated skin wounds. Though the degree of contraction in the PYC-treated group was lower than that of the control group from days 1 to 5, but appeared significantly higher on day 7. Compared to the control group, collagen accumulation in the PYC-treated group was higher than that of the control group from days 5 to 7. From this result, it may support the possibility that PYC would be useful agent for early inflammatory response and matrix remodeling phase of the skin wounds.
Skin wound healing;Pycnogenol;Mice;
 Cited by
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