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Effect of Pycnogenol on Skin Wound Healing
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  • Journal title : Applied Microscopy
  • Volume 43, Issue 4,  2013, pp.133-139
  • Publisher : Korean Society of Electron Microscopy
  • DOI : 10.9729/AM.2013.43.4.133
 Title & Authors
Effect of Pycnogenol on Skin Wound Healing
Jeong, Moon-Jin; Jeong, Soon-Jeong; Lee, Soo-Han; Kim, Young-Soo; Choi, Baik-Dong; Kim, Seung-Hyun; Go, Ara; Kim, Se Eun; Kang, Seong-Soo; Moon, Chang-Jong; Kim, Jong-Choon; Kim, Sung-Ho; Bae, Chun-Sik;
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 Abstract
This study was carried out to investigate the effects of pycnogenol (PYC) on the cutaneous wound healing of the mice. The wounds were extracted on days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area, infiltrating inflammatory cells, wound contracture including collagen deposition. As the result, the wound area of PYC-treated group was larger than the control group on days 1 to 7. Inflammatory cells in the PYC-treated wounds were decreased at day 1 compared to the control wound tissue. From day 3 to 7, there was no significant difference between the control and the PYC-treated skin wounds. Though the degree of contraction in the PYC-treated group was lower than that of the control group from days 1 to 5, but appeared significantly higher on day 7. Compared to the control group, collagen accumulation in the PYC-treated group was higher than that of the control group from days 5 to 7. From this result, it may support the possibility that PYC would be useful agent for early inflammatory response and matrix remodeling phase of the skin wounds.
 Keywords
Skin wound healing;Pycnogenol;Mice;
 Language
English
 Cited by
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