JOURNAL BROWSE
Search
Advanced SearchSearch Tips
The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in Dinitrochlorobenzene-Induced BALB/c Mice
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Applied Microscopy
  • Volume 44, Issue 2,  2014, pp.53-60
  • Publisher : Korean Society of Electron Microscopy
  • DOI : 10.9729/AM.2014.44.2.53
 Title & Authors
The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in Dinitrochlorobenzene-Induced BALB/c Mice
Chu, Han-Na; Kim, Jeong-Sang;
  PDF(new window)
 Abstract
In the present study, we investigated the effects of Polygonum tinctoria Niram (PTN) on atopic dermatitis (AD) in BALB/c mice induced by 2,4-dinitrochlorobenzene (DNCB). They were divided into four groups; Control, DNCB, DNCB+1%PTN (1% PTN extract) and DNCB+5%PTN (5% PTN extract), for evaluating the change of appearance of skin surface, skin hydration, thickness of epidermis and mast cell numbers during 4 weeks. PTN suppressed symptoms of AD in appearance of skin and increased skin hydration for DNCB+1%PTN and DNCB+5%PTN. Treatment with PTN significantly decreased the levels of eosinophils. In histopathological examination, DNCB+1%PTN and DNCB+5%PTN significantly reduced the thickness of epidermis and number of mast cell in dermis. These results suggested that the PTN improved symptoms of AD in BALB/c mice.
 Keywords
Polygonum tinctoria Niram;Atopic dermatitis;Mast cell;2,4-dinitrochlorobenzene;BALB/c mice;
 Language
English
 Cited by
 References
1.
Ahn J Y, Im L R, Kim J H, Park J H, Kim D K, and Lee Y M (2009) Effects of Rumecis Radix water extract on development of atopic dermatitis in BALB/c mice. Korean J. Pharmacogn. 40, 218-223.

2.
Choi M J, Jung H K, Jeong Y S, Park S C, and Hong J H (2010) Anti-allergic activities of fermented Eriobotrya japonica and Saurus chinensis extracts in 2,4-dinitrochlorobezene-induced BALB/c mice. J. Korean Soc. Food Sci. Nutr. 39, 1611-1618. crossref(new window)

3.
Choi E Y (2006) Comparison of state of skin surface using skin instrumental measurements. Korean J. Aesthet. Cosmetol. 4, 1-10.

4.
Choi Y J, Lee C S, and Kim J M (2012) Distribution of mouse uterine mast cells during estrous cycles. Dev. Reprod. 16, 113-120.

5.
Facoetti A, Fakkarini S, Miserere S, Bertolotti A, Ferrero I, Tozzi R, Gatti C, Palladimi G, Perlini S, and Nano R (2006) Histrochemical study of cardiac mast cells degranulation and collagen deposition: interaction with the cathecolaminergic system in the rat. European J. Histochem. 50, 133-140.

6.
Haoli J, Rui H, Michiko O, and Raif S G (2009) Animal models of atopic dermatitis. J. Invest. Dermatol. 129, 31-40. crossref(new window)

7.
Jang S E, Lee N K, Lee Y R, Choi M S, and Jeong Y S (2013) Isolation and characterization of Commanomase sp. and Microbacterium sp. from deep blue sediment dye of Polygoum tictoria, Niram. J. Korean Soc. Biotechnol. Bioeng. 28, 60-64.

8.
Jencrowicz D, Czarnecka-Operacz M, and Silny W (2007) Peripheral blood eosinophilia in atopic dermatitis. Acta Dermatov. APA 16, 47-52.

9.
Ki H P, Jang S I, and You Y G (2013) Ameliorative effects of Hwangnyeonhaedok- tang on atopic dermatitis. Herb. Form. Sci. 21, 80-90. crossref(new window)

10.
Kim D H, Lee K J, Qi X F, Lee Y M, Yoon Y S, Kim J L, Chang B S, and Ryang Y S (2008) The effects of magnesium rich sea mineral water on atopic dematitis-like skin lesions in hairless mice. Korean J. Microsc. 38, 167-174.

11.
Kim H S, Oh T H, Song J C, Kim D I, Lim A K, Yang D C, In J G, Kim Y C, and Kim K S (2010) Inhibitory effects of korean red ginseng extract on atopic dermatitis in NC/Nga mice. Lab. Anim. Res. 26, 365-271.

12.
Kwon H Y (2013) The anti-atopic effect on flavonol content from Ginkgo biloba leaves on NC/Nga murine model with mast cell and DNCBinduced atopy. Dept. of Beauty and Health Care. Thesis, (Graduate School of Daejeon University, Daejeon).

13.
Lee G S, Pena I D, Choi J Y, Yoon S Y, and Choi J H (2008) Effect of SPZZC, a composition of herb extracts, on atopic dermatitis in BALB/c and NC/Nga mouse. J. Pharm. Soc. Korea 52, 232-239.

14.
Lee M S and Chung K H (2012) The development bedclothes design through the application of natural indigo dyeing. J. Korean Soc. Design Culture 18, 356-367.

15.
Lee S H, Kim Y C, and Lee J S (2011) A study on potential effectiveness of german chamomile oil in Atopic dermatitis. J. Korea Soc. Beauty Art 12, 37-48.

16.
Lee Y H, Kim K T, Han U H, Kim H T, Park B G, Lee M S, and Song C H (2006) Histochemical Characteristics and Ultrastructure of Mast Cells in Pheasant (Phasianus colchicus). Korean J. Anat. 39, 367-374.

17.
Li C, Lasse S, Lee P, Nakasaki M, Chen S W, Yamasaki K, Gallo R L, and Jamora C (2010) Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proceedings of the National Academy of Sciences of the United States of America 107, 22248-22254.

18.
Li Y Z, Lu X Y, Jiang W, and Li L F (2013) Anti-inflammatory effect of Qingpeng ointment in atopic dermatitis-like murine model. Evid. Based Complement. Alternat. Med. doi: 10.1155/2013/907016. crossref(new window)

19.
Mizutani H, Nishiguchi T, and Murakami T (2004) Animal models of atopic dermatitis. J. Japan Med. Assoc. 47, 501-507.

20.
Nagai M and Okunishi I (2009) The effect of Wasabi Rhizome extract on atopic dermatitis-like symptoms in HR-1 hairless mice. J. Nutr. Sci. Vitaminol. 55, 195-200. crossref(new window)

21.
Park B S, Park S O, Ahn Y S, Ryu C M, Noh H Y, and Noh G Y (2012) Therapeutic effects of atobeauty cream in atopic dermatitis model mice induced DN CB. Research J. Med. Sci. 6, 71-76.

22.
Park D H and Kim Y U (2008) Screening of anti-atopic dermatitis material by using NC/Nga mouse whole blood system. Immun. Netw. 8, 98-105. crossref(new window)

23.
Park S O, Park B S, Ryu C M, and Ahn Y S (2012) Effect of herb extracts mixed with Houttuynia Cordata on antiatopic dematitis in DNCBincluded BALB/c mouse. J. Korean Oil Chem. Soc. 29, 175-183.

24.
Seema V and Pattankar V L (2011) Mast cell variation in some commonly encountered lesions of salivary glands. Res. J. Pharm. Biol. Chem. Sci. 2, 19-27.

25.
Shukla S A, Veerappan R, Whittimore J S, Miller L E, and Youngberg G A (2005) Mast cell ultrastructure and staining in tissue. Method Mol. Biol. 315, 63-76.

26.
Yagi R, Nagai H, Iigo Y, Akimoto T, Arai T, and Kubo M (2002) Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice. J. Immunol. 168, 2020-2027. crossref(new window)

27.
Zheng H, Jeong Y J, Song J M, and Ji G E (2011) Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitislike skin lesions induced by oxazolone in hairless mice. Int. Immunopharm. 11, 511-518. crossref(new window)

28.
Zhou S L, Tan G H, Huang F Y, Wang H, Lin Y Y, and Chen S L (2014) Sanpao herbs inhibit development of atopic dermatitis in Balb/cmice. Asian Pac. J. Allergy Immunol. 32, 3-7.