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Fermented Saccharina japonica (Phaeophyta) improves neuritogenic activity and TMT-induced cognitive deficits in rats
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  • Journal title : ALGAE
  • Volume 31, Issue 1,  2016, pp.73-84
  • Publisher : The Korean Society of Phycology
  • DOI : 10.4490/algae.2016.31.11.10
 Title & Authors
Fermented Saccharina japonica (Phaeophyta) improves neuritogenic activity and TMT-induced cognitive deficits in rats
Park, Hyun-Jung; Lee, Mi-Sook; Shim, Hyun Soo; Lee, Gyeong-Ran; Chung, Sun Yong; Kang, Young Mi; Lee, Bae-Jin; Seo, Yong Bae; Kim, Kyung Soo; Shim, Insop;
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Marine organisms are frequently used to be harmful and have lower side effects than synthetic drugs. The cognitive improving efficacy of gamma aminobutyric acid-enriched fermented Saccharina japonica (FSJ) on the memory deficient rats, which were induced by trimethyltin chloride (TMT), was investigated by assessing the Morris water maze test and by performing choline acetyltransferase (ChAT), cAMP response element binding protein (CREB), and brain derived neurotrophic factor (BDNF) immunohistochemistry. The neurite outgrowth of Neuro2a cells was assessed in order to examine the underlying mechanisms of the memory enhancing effects of FSJ. Treatment with FSJ tended to shorten the latency to find the platform in the acquisition test of the Morris water maze at the second and fourth day compared to the control group. In the probe trial, the FSJ treated group increased time spent in the target quadrant, compared to that of the control group. Consistent with the behavioral data, these treatments recovered the loss of ChAT, CREB, and BDNF immunepositive neurons in the hippocampus produced by TMT. Treatment with FSJ markedly stimulated neurite outgrowth of the Neuro2a cells as compared to that of the controls. These findings demonstrate that FSJ may be useful for improving the cognitive function via regulation of neurotrophic marker enzyme activity.
brain derived neurotrophic factor;cAMP response element binding protein;gamma aminobutyric acid;Morris water maze;Saccharina japonica;trimethyltin;
 Cited by
정상 동물모델에서 다시마(Saccharina japonica) 발효물의 기억력 개선 효과,류제광;조영홍;장성준;이배진;

한국수산과학회지, 2016. vol.49. 2, pp.131-136 crossref(new window)
Effects of γ-aminobutyric acid-enriched fermented sea tangle (Laminaria japonica) on brain derived neurotrophic factor-related muscle growth and lipolysis in middle aged women,;;;;;;

ALGAE, 2016. vol.31. 2, pp.175-187 crossref(new window)
Ginsenoside Rd as a potential neuroprotective agent prevents trimethyltin injury, Biomedical Reports, 2017, 6, 4, 435  crossref(new windwow)
Effects of γ-aminobutyric acid-enriched fermented sea tangle (Laminaria japonica) on brain derived neurotrophic factor-related muscle growth and lipolysis in middle aged women, ALGAE, 2016, 31, 2, 175  crossref(new windwow)
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