Advanced SearchSearch Tips
The Antioxidant and Anticancer Effects of MeOH Extract of Liriodendron tulipifera
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Plant Resources
  • Volume 24, Issue 1,  2011, pp.23-29
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2011.24.1.023
 Title & Authors
The Antioxidant and Anticancer Effects of MeOH Extract of Liriodendron tulipifera
Xu, Ming-Lu; Wang, Lan; Wang, Myeong-Hyeon;
  PDF(new window)
In order to screen the functional constituents from nature resource, we studied the bioactivities of methanol extract of the Liriodendron tulipifera branch(MLT). The total phenolic and flavonoid contents, DPPH radical scavenging capacity, reducing power, chelating ability, inhibition of lipid peroxidation and cell toxicity of MLT were investigated in this study. We found that the total phenolic and flavonoid content of MLT is 75.34 mg gallic acid/g and 20.15 mg quercetin/g respectively. MLT exhibited the antioxidant activity on DPPH radical with a value of /mL, the absorbance is 0.388 at /mL in reducing power assay, MLT prevented 38.56% lipid peroxidation at /mL. Furthermore, MLT exhibits the potent anti-proliferative activity which inhibited 56.94%, 35.73% growth of HT-29 and Hela cell at /mL respectively. It showed that the antioxidant activities of MLT were correlated with its total phenolic and flavonoid contents. However further study need to be exploring in the future.
Liriodendron tulipifera;Antioxidant;Anticancer;Anti-lipid peroxidation;
 Cited by
녹비작물 추출물의 감자 더뎅이병균에 대한 항균력 검정,박종인;정희정;배용희;강권규;노일섭;

한국자원식물학회지, 2011. vol.24. 5, pp.622-627 crossref(new window)
숙지황(Rehmannia glutinosa) 추출물의 생리활성,조영제;

생명과학회지, 2012. vol.22. 7, pp.943-949 crossref(new window)
딱총나무(Sambucus williamsii var. coreana) 추출물의 항산화효과,채정우;조영제;

한국자원식물학회지, 2012. vol.25. 4, pp.363-371 crossref(new window)
Inhibitory Effect of the Ethyl Acetate Fraction from Tulip Tree Leaf (Liriodendron tulipifera L.) on Adipogenesis in 3T3-L1 Cells,;;;;

Natural Product Sciences, 2013. vol.19. 3, pp.263-268
감마선 조사에 의한 총목피(Aralia elata Cortex)의 추출수율 증대 및 항산화 효과,박혜진;조영제;

한국자원식물학회지, 2014. vol.27. 5, pp.429-438 crossref(new window)
The Effect on Anti-oxidative Activity and Increasing Extraction Yield of Aralia elata Cortex by Gamma Irradiation, Korean Journal of Plant Resources, 2014, 27, 5, 429  crossref(new windwow)
Charactrization of Biological Activities of Rehmannia glutinosa Extracts, Journal of Life Science, 2012, 22, 7, 943  crossref(new windwow)
Antioxidative Activity of Extracts from Sambucus williamsii var. coreana, Korean Journal of Plant Resources, 2012, 25, 4, 363  crossref(new windwow)
LED Lights Enhance Metabolites and Antioxidants in Chinese Cabbage and Kale, Brazilian Archives of Biology and Technology, 2016, 59, 0  crossref(new windwow)
Antimicrobial Activity against Potato Common Scab (Streptomyces scabiei) of Green Manure Crop Extracts, Korean Journal of Plant Resources, 2011, 24, 5, 622  crossref(new windwow)
Banerjee, A., N. Dasgupta and B. De. 2005. In vitro study of antioxidant activity of Syzygium cumini fruit. Food Chem. 90:727-733. crossref(new window)

Birt, B.F., S. Hendrich and W.Q. Wang. 2001. Dietary agents in cancer prevention: flavonoids and isoflavoids. Pharmacol. Ther. 90:157-177. crossref(new window)

Blois, M.S. 1958. Antioxidant determination by the use of a stable free radical. Nature 181:1199-1200. crossref(new window)

Buchanan, M.A. and E.E. Dickey. 1960. Liriodenine, a nitrogen-containing pigment of yellow poplar heartwood (Liriodendron tulipifera L.). J. Org. Chem. 25:1389-1391 crossref(new window)

Chang, C.C., M.H. Yang, H.M. Wen and J.C. Chern. 2002. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J. of Food and Drug Analysis 10:178-182.

Chen, C.L., H.M. Chang and E.B. Cowling. 1976. Aporphine alkaloids and lignans in heartwood of Liriodendron tulipifera. Phytochemistry 15:547-550. crossref(new window)

Chen, C.L., H.M. Chang, E.B. Cowling, C.Y. Huang Hsu, R.P. Gates. 1976. Aporphine alkaloids and lignans formed in response to injury of sapwood in Liriodendron tulipifera. Phytochemistry 15:1161-1167. crossref(new window)

Chen, C.L. and H.M. Chang. 1978. Lignans and aporphine alkaloids in bark of Liriodendron tulipifera. Phytochemistry 17:779-782. crossref(new window)

Choi, C.H., E.S. Song, J.S. Kim and M.H. Kang. 2003. Antioxidative activities of Castanea crenata Flos. methanol extracts. Kor. J. Food Sci. Technol. 35:1216-1220 (in Korean).

Choi, S.Y., S.H. Lin, T.Y. Ha, S.R. Kim, K.S. Kang and I.K. Hwang. 2005. Evaluation of the estrogenic and antioxidant activity of some edible and medicinal plant. Kor. J. Food Sci. Technol. 37:549-556.

Cohen, J., W. Von Langenthal and W. Taylor. 1961. Notesthe alkaloids of Liriodendron tulipifera L. The structure and synthesis of the unnamed yellow alkaloid and the isolation of D-glaucine. J. Org. Chem. 26:4143-4144. crossref(new window)

Doskotch, R.W. and F.S. El-Feraly. 1969. Antitumor agents. II. Tulipinolide, a new ger-macranolide sesquiterpene, and constunolide. Two cytotoxic substances from Liriodendron tulipifera L. J. Pharm. Sci. 58:877-880. crossref(new window)

Doskotch, R.W. and F.S. El-Feraly. 1970. The structure of tulipinolide and epitulipino- lide. Cytotoxic sesquiterpenes from Liriodendron tulipifera L. J. Org. Chem. 35:1928-1936. crossref(new window)

Doskotch, R.W., F.S. El-Feraly, E.H. Fairchild and C.-T. Huang. 1976. Peroxyferolide: a cytotoxic gerrnacranolide hydroperoxide from Liriodendron tulipifera. J. Chem. Soc. Chem. Comm. 402-403.

Doskotch, R.W., F.S. El-Feraly, E.H. Fairchild and C.-T. Huang. 1977. Isolation and characterization of peroxyferolide, a hydroperoxy sesquiterpene lactone from Liriodendron tulipifera. J. Org. Chem. 42:3614-3618. crossref(new window)

Doskotch, R.W., S.L. Keely, C.D. Hufford, F.S. El-Feraly. 1975. New sesquiterpene lactones from Liriodendron tulipifera. Phytochemistry 14:769-773. crossref(new window)

Eom, S.H., H.J. Park, C.W. Jin, S.M. Park, M.J. Kim, C.Y. Yu and D.H. Cho. 2007. Changes of antioxidant activity in Juglans mandshurica Maxim. leaves by far infrared ray inradiation. Kor. J. Med. Crop Sci. 15:266-270 (in Korean).

Goh, E.J., E.S. Seong, J.G. Lee, J.K. Na, J.D. Lim, M.J. Kim, N.Y. Kim, G.H. Lee, J.S. Seo, D.S. Cheoi, I.M. Chung and C.Y. Yu. 2009. Antioxidant activities according to peelling and cultivated years of Astragalus membranaceus Roots. Kor. J. Med. Crop Sci. 17:233-237 (in Korean).

Gordon, M.F. 1990. The mechanism of antioxidant action in vitro. In Food antioxidants. Hudson BJF, ed. Elsevier Applied Science, London, UK. p 1-18.

Graziose, R., T. Rathinasabapathy, C. Lategan, A. Poulev, P.J. Smith, M. Grace, M.A. Lila and I. Raskin. 2010. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L. J. of Ethnopharmacology (in press).

Green, L.M., J.L. Reade and C.F. Ware. 1984. Rapid colometric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines. J. of Immunological Methods 70:257-268. crossref(new window)

Hasegawa, G.R. 2007. Quinine substitutes in the confederate army. Military Medicine 172:650-655. crossref(new window)

Kang Y.H., Y.K. Park, S.R. Oh and K.D. Moon. 1995. Studies on the physiological functionality of ine needle and mugwort extracts. Kor. J. Food Sci. Technol. 27: 978-984 (in Korean).

Kim, H.S. and Y.H. Kang. 2010. Antioxidant activity of ethanol extracts of non-edible parts (stalk, stem.leaf, seed) from oriental Melon. Kor. J. Plant Res. 23(5): 451-457 (in Korean).

Kim, T.W. 1995. The woody plants of Korea in color, Kyo- Hak publishing Co. Ltd. Seoul. p. 101.

Lee, J.H. and S.R. Lee. 1994. Analysis of phenolic substances content in Korean plants foods. Kor. J. Food Sci. Technol. 26:310-316 (in Korean).

Lee, Y.R., M.Y. Kang, H.J. Koh, J.H. Chin and S.H. Nam. 2004. Screeing of physiological functionality of germainatedgiant embryonic rices. J. Kor. Soc. Appli. Biolo. Chem. 47:216-221.

Lin, J.Y., and C.Y. Tang. 2007. Determination of total phenolic and flavonoid contents in selected freits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chem. 101:140-147. crossref(new window)

Merkle, S.A. and H.E. Sommer. 1991. Yellow-poplar (Liriodendron spp.). In YPS Bajaj, ed, Biotechnology in agriculture and forestry, trees III, Vol.16, Springer-verlag, Berlin, p. 94-110.

Muhammad, I. and C.D. Hufford. 1989. Phenylpropanoids, sesquiterpenes, and alka- loids from the seeds of Liriodendron tulipifera. J. Nat. Prod. 52:1177-1179. crossref(new window)

Rafinesque, C.S. and A. Atkinson. 1828. Medical Flora, or, Manual of the Medical Botany of the United States of North America. In: Rafinesque, C.S., Atkinson, Alexander (Eds.), Alexander, Philadelphia.

Rhim, T.J. and M.Y. Choi. 2010. The antioxidative effects of Ampelopsis brevipedunculata extracts. Kor. J. Plant Res. 23(5):445-450 (in Korean).

Spencer, C.F., F.R. Koniuszy, E.F. Rogers, J. Shavel, N.R. Easton, E.A. Kaczka, F.A. Kuehl, R.F. Phillips, A. Walti, K. Folkers, C. Malanga and A.O. Seeler. 1947. Survey of plants for antimalarial activity. Lloydia 10:145-174.

Taylor, W.I. 1961. The structure and synthesis of liriodenine, a new type of isoquino- line alkaloid. Tetrahedron 14:42-45. crossref(new window)

Yen, G.C., P.D. Duhb, and H.L. Tsaia. 2002. Antioxidant and pro-oxidant properties of ascorbic acid and gallic acid. Food Chem. 79:307-313. crossref(new window)