Advanced SearchSearch Tips
Antioxidative Activity and Cytotoxicity of Fermented Allium victorialis L. Extract
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Plant Resources
  • Volume 24, Issue 1,  2011, pp.30-39
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2011.24.1.030
 Title & Authors
Antioxidative Activity and Cytotoxicity of Fermented Allium victorialis L. Extract
Doh, Eun-Soo; Chang, Jun-Pok; Kil, Ki-Jung; Choi, Myung-Suk; Yang, Jae-Kyung; Yun, Chung-Weon; Jeong, Sun-Mi; Jung, Yun-Hae; Lee, Gun-Hee;
  PDF(new window)
This study was conducted to investigate the antioxidative activity and cytotoxicity of fermented Allium victorialis extract. The results were as follows; The total polyphenol content of A. victorialis extract was 2.63 mg/g, and that of fermented A. victorialis extract was 1.65 mg/g which decreased a little by fermentation. The total flavonoid content of A. victorialis extract was 57.77 mg/g, and that of fermented A. victorialis extract was 62.27 mg/g, and this could increase a little from fermentation. Electron donating ability of A. victorialis extract was lower than vitamin C(97.71%), but before fermentation it was 82.29% and after fermentation it became 82.40%. Nitrite scavenging ability of A. victorialis extract before and after fermentation showed lower numerical value than that of butylated hydroxytoluene(BHT) at pH 2.5 but that of A. victorialis extract expressed higher than that of BHT. Superoxide dismutase-like activity showed relatively low level, 15%. Nitrite production increased by A. victorialis extract but was inhibited after fermentation. Methyl diamphetamine (MDA) content was inhibited with increased concentration of A. victorialis extract compared with treatment but there was not any difference before and after fermentation. Therefore, production of lipid peroxide(LPO) was inhibited by A. victorialis extract. Cell viability of fibroblast cell was tend to slightly decrease with increased concentration of A. victorialis extract, but not different with control.
Fermentation;Antioxidative activity;Cytotoxicity;A. victorialis;
 Cited by
산마늘 자생지의 임분구조와 식물종의 연관,김혜진;윤춘원;도은수;장준복;최명석;양재경;박희권;신학섭;이서희;배관호;조현제;

한국산림과학회지, 2011. vol.100. 4, pp.565-576
Alloxan에 의한 HIT-T15 세포의 산화적 손상에 대한 매실(Prunus mume Sieb. et Zucc.) 주정추출물의 세포보호효과,김인혜;김종배;조강진;김재현;엄애선;

한국자원식물학회지, 2012. vol.25. 2, pp.184-192 crossref(new window)
SK-N-SH 신경세포내 항산화 효과와 p38 인산화 억제에 의한 곤드레, 누룩치 그리고 산마늘의 신경 보호 효과,정미자;박용일;권기한;

한국식품영양과학회지, 2015. vol.44. 3, pp.347-355 crossref(new window)
제주 자생 식물들의 항산화 활성 능력 검색,장현주;부희정;이선주;

한국자원식물학회지, 2015. vol.28. 2, pp.158-167 crossref(new window)
비만 흰쥐에서 발효 서목태의 항산화 효과,배귀정;하배진;

한국식품위생안전성학회지, 2015. vol.30. 4, pp.383-389 crossref(new window)
배 품종별 생육 단계에 따른 산화방지 및 미백 효과,임순희;조광식;최진호;이주현;김명수;이별하나;

한국식품과학회지, 2016. vol.48. 1, pp.59-65 crossref(new window)
The Effects of Spring Kimchi Cabbage Pre-treatment and Storage Conditions on Kimchi Quality Characteristics,;;;;;

원예과학기술지, 2017. vol.35. 6, pp.747-757 crossref(new window)
Cytoprotective Effect of Ethanol Extract from Maesil (Prunus mume Sieb. et Zucc.) on Alloxan-induced Oxidative Damage in Pancreatic-cell, HIT-T15, Korean Journal of Plant Resources, 2012, 25, 2, 184  crossref(new windwow)
Effect of Various Pear Cultivars at Different Fruit Development Stages on Antioxidant and Whitening Activities, Korean Journal of Food Science and Technology, 2016, 48, 1, 59  crossref(new windwow)
Neuroprotective Effects of Cirsium setidens, Pleurospermum kamtschaticumin, and Allium victorials Based on Antioxidant and p38 Phosphorylation Inhibitory Activities in SK-N-SH Neuronal Cells, Journal of the Korean Society of Food Science and Nutrition, 2015, 44, 3, 347  crossref(new windwow)
Antioxidative Effect of Fermented Rhynchosia nulubilis in Obese Rats, Journal of Food Hygiene and Safety, 2015, 30, 4, 383  crossref(new windwow)
Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 24, 7465  crossref(new windwow)
Screening for Antioxidative Activity of Jeju Native Plants, Korean Journal of Plant Resources, 2015, 28, 2, 158  crossref(new windwow)
Evaluation of Antioxidant, Anti-Inflammatory, Antithrombotic, and Antiobesity Activities in Cultured Edible Plants to Increase Farm Income, The Korean Journal of Community Living Science, 2017, 28, 1, 29  crossref(new windwow)
Bae, Y.I., C.H. Jeong and K.H. Shim. 2002. Nitrite-scavenging and antimutagenic effect of various solvent extract from different parts of loquat (Eriobotrya japonica, Lindl). Kor. J. of Food Preservation. 9:92-96 (in Korean).

Baehner, R.L., S.K. Murrmann, J. Davis and R.B.Jr. Johnson. 1975. The role of superoxide anjon and hydrogen peroxide in phagocytosis-associated oxidative metabolic reactions. J. Clin Invest. 56:571-576. crossref(new window)

Boo, H.O., H.H. Lee, J.W. Lee, S.J. Hwang and S.U. Park. 2009. Different of total phenolics and flavonoids, radical scavenging activities and nitrite scavenging effects of Momordica charantia L. according to cultivars. Kor. J. of Medicinal Crop Sci. 17:15-20 (in Korean).

Choi, B.D., C.S. Park and E.Y. Joo. 2008a. Physiological activities of korean and chinese Viola mandshurica extracts. J. Kor. Soc. Food Sci. Nutr. 37:1101-1108 (in Korean). crossref(new window)

Choi, J.H and S.K. Oh. 1985. Studies on the antiaging of korean ginseng. Korean J. Food. Sci. Technol. 17:506- 515 (in Korean).

Choi, J.W., K.T. Lee, W.B. Kim, K.K. Park, W.Y. Chung, J.H. Lee, S.C. Lim, H.J. Jung and H.J. Park. 2005. Effect of Allium victorialis var. platyphyllum leaves on triton WR- 1339-induced and poloxamer-407-induced hyperlipidemic rats and on diet-induced obesity rats. Kor. J. Pharmacogn. 36:109-115 (in Korean).

Choi, S.R., D.H. You, J.Y. Kim, C.B. Park, J. Ryu, D.H. Kim and J.S. Eun 2008b. Antioxidant and antimicrobial activities of Artemisia capillaris Thunberg. Kor. J. Medicinal Crop Sci. 16:112-117 (in Korean).

Chung, H.S. 2001. Isolation of new bioactive phytochemicals from natural products. Food Industry and Nutrition 6:53-59 (in Korean).

Cross, E.E., B. Halliwell, E.T. Borish. W.A. Pryor, B.N. Ames, R.L. Saul and J.M. McCord. 1987. Oxygen radicals and human disease (clinical conference). Ann. Intren. Med. 107:526-545. crossref(new window)

Duh, P.D., Y.Y. Tu and G.C. Yen 1999. Antioxidant activity of water extract of Harng Jyur (Chrysanthemum morifolium Ramat). Lebensm Wiss Technol. 32:269-277 (in Korean). crossref(new window)

Folin, O. and W. Denis 1915. A colorimetric method for determination of phenols (phenol derivatives) in urine. J. Biol. Chem. 22:305-308.

Halliwell B. 1987. Oxidants and human disease: some new concepts. Fase. J. 1:258-364.

Ham, S.S., C.B. Cui, H.T. Choi and D.S. Lee. 2004. Antimutagenic and cytotoxic effects of Allium victorialis extracts. Kor. J. Food Preservation. 11:221 (in Korean).

Han, H.S., W.S. Park and Y.J. Lee. 2008. Studies on the immunomodulating activity of fermented Artemisiae Argyi Folium extract. Kor. J. Herbology 23:103-112 (in Korean).

Heo, S.I. and M.H. Wang. 2008. Antioxidant activity and cytotoxicity effect of extracts from Taraxacum mongolicum H. Kor. J. Pharmacogn. 39:255-259 (in Korean).

Hong, G.T., Y.R. Lee. M.H. Yim and C.N. Hyun. 2004. Physiological functionality and nitrite scavenging ability of fermentation extracts from pine needles. Kor. J. Food Preserv. 11:94-99 (in Korean).

Jang, E.K., J.H. Seo and S.P. Lee. 2008. Physiological activity and antioxidative effects of aged black garlic (Allium sativum L.) extract. Kor. J. Food Sci. Technol. 40:443-448 (in Korean).

Joo, E.Y., Y.S. Lee and N.W. Kim. 2007. Polyphenol compound contents and physiological activities in various extracts of the Vitex rotundifolia stems. J. Kor. Soc. Food Sci. Nutr. 36:813-818 (in Korean). crossref(new window)

Jung, M.H., Y. Yin, S.I. Heo and M.H. Wang. 2008. Antioxidant and anticancer activities of extract from Artemisia capillaries. Kor. J. Pharmacogn. 39:194-198 (in Korean).

Kato, H., I.E. Lee, N.V. Chuyen, S.B. Kim and F. Hayase. 1987. Inhibition of nitrosamine formation by nondialyzable melanoidines. Agric. Biol. Chem. Tokyo 51:1333-1338. crossref(new window)

Kawaguchi, K., T. Mizuno, K. Aida and K. Uchino. 1997. Hesperidin as an inhibitor of lipases from porcine pancreas and pseudomonas. Biosci. Biotech. and Biochem. 61:102-104. crossref(new window)

Kedziora, J. and G. Bartosz. 1998. Down's syndrome: a pathway involving the lack of balance of reactive oxygen species. Free Radic. Biol. Med. 4:317-330.

Kim, E.Y., I.H. Baik, J.H. Kim, S.R. Kim and M.R. Rhyu. 2004. Screening of the antioxidant activity of some medicinal plants. Kor. J. Food Sci. Technol. 36:333-338.

Kim, J.Y., J.A. Lee, K.N. Kim, G.P. Song and S.Y. Park. 2007. Antioxidative and antimicrobial activities of Euphorbia helioscopia extracts. J. Kor. Soc. Food Sci. Nutr. 36:1106- 1112 (in Korean). crossref(new window)

Kim, T.G., S.H. Kim, S.Y. Kang, K.K. Jung, D.H. Choi, Y.B. Park, J.H. Ryu and H.M. Han. 2000. Antiatherogenic effect of the extract of Allium victorialis on the experimental atherosclerosis in the rabbit and transgenic mouse. Kor. J. Pharmacogn. 31:149-156 (in Korean).

Kim, W.B., J.K. Kim, E.A. Lee, B.H. Kim and H.T. Lim. 1996. Intraspecific variations of the Allium victorials var. platphyllum by polymerase chain reaction. J. Kor. Soc. Hort. Sci. 38:129-132 (in Korean).

Kitani, K., C. Minami, T. Amamoto, S. Kanai, G.O. Ivy and M.C. Carrillo. 2002. Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. Ann. N. Y. Acad. Sci. 959:295-307. crossref(new window)

Lee, E.S. 2008. Effect of AVP (Allium victorialis var. palatyphyllum) extract on the apoptosis in human hepatoma cell. Duksung women's university. p. 44 (in Korean).

Lee, H.B., H.J. Kim, M.S. Chong, H.U. Cho, Y.H. Choi, K.S. Lim and K.N. Lee. 2008. Physiological activity of extracts from mixed culture of medical herbs and mycelia of Tricholoma matsutake and Cordyceps militaris by fermentation. Kor. J. Herbology 23:1-8 (in Korean).

Lee, H.J., S.K. Lee, Y.J. Choi, H.J. Jo, H.Y. Kang, S.S. Lee and D.H. Choi. 2007. Extractives from the Allium victorials. J. Kor. For. Soc. 96:620-624 (in Korean).

Lee, K.I. and S.M. Kim. 2009. Antioxidative and antimicrobial activities of Eriobotrya japonica Lindl. leaf extracts. J. Kor. Soc. Food Sci. Nutr. 38:267-273 (in Korean). crossref(new window)

Lee, S.G., H.J. Kim, S.P. Lee and I.S. Lee. 2009a. Antioxidant and anticancer activities of defatted soybean grits fermented by Bacillus subtilis NUCI. J. Kor. Soc. Food Sci. Nutr. 38:657-662 (in Korean). crossref(new window)

Lee, S.S., S.H. Moon, H.J. Lee, D.H. Choi and M.H. Cho. 2004. Cholesterol inhibitory activities of kaempferol and quercetin isolated from Allium victorialis var. platyphyllum. Mokchae Konghak. 32:17-27 (in Korean).

Lee, Y.S. 2007. Antioxidative and physiological activity of extracts of Angelica dahurica leaves. Kor. J. Food Preserv. 14:78-86 (in Korean).

Lee, Y.S., B.D. Choi, E.Y. Joo and S.R. Shin. 2009b. Antioxidative activities and tyrosinase inhibition ability in various extracts of the Vitex rotundifolia seeds. Kor. J. Food. Preserv. 16:101-108 (in Korean).

Leong, L.P. and G. Shui. 2002. An investigation of antioxidant capacity of fruits in singapore markets. Food Chemistry. 76:69-75. crossref(new window)

Lim, J.A., E.S. Lee and S.H. Baek. 2008. Antioxidative activity and nitrite scavenging ability of ethanol extract from Nelunmbo nucifera leaves. Kor. J. Oriental Physiology & Pathology 22:654-659 (in Korean).

Marklund, S. and G. Marklund. 1974, Involvement of superoxide anion radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47:468-474.

Marnett, L.J. 1987. Peroxyl free radicals: Potential mediators of tumor initiation and promotion. Carcinogenesis 8:1365-1373 crossref(new window)

Middleton, E. and C. Kandaswami. 1994. Potential health-promoting properties of citrus flavonoids. Food Tech. 48:115-119.

Nakagawa, M. and I. Amano. 1974. Evaluation method of green tea grade by nitrogen analysis. J. of Japanese Food Sci. and Tech. 21:57-63. crossref(new window)

Nishimura, H., C.H. Wijaya and J. Mizutani. 1998. Volatile flavor components and antithrombotic agents: Vinyldithiins from Allium victorialis L. J. Agric. Food Chem. 36:563-566.

Oh, H.J. and C.S. Kim. 2007. Antioxidant and nitrite scavenging ability of fermented soybean foods (chungkukjang, Doenjang). J. Kor. Soc. Food Sci. Nutr. 36:1503-1510 (in Korean). crossref(new window)

Ohkawa, H., N. Ohishi and K. Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. Jun. 95:351-8. crossref(new window)

Park, S.J., S.W. Song, D.H. Seong, D.S. Park, S.S. Kim, J.Y. Gou, J.H. Ahn, W.B. Yoon and H.Y. Lee. 2009. Biological activities in the extract of fermented Codonopsis lanceolata. J. Kor. Soc. Food Sci. Nutr. 38:983-988 (in Korean). crossref(new window)

Park, S.N. 1997. Skin aging and antioxidants. J. Soc. Cos. Chem. Kor. 23:75-132 (in Korean).

Patt, J., A.H. Harken, L.K. Burton, T.C. Rodell, D. Piermareei, W.J. Schorr, N.B. Parker, E.M. Berger, I.R. Horesh, L.S. Terada, S.I. Linas, J.C. Cheronis and J.E. Repine. 1988. Xanthine oxidase derived hydrogen peroxide contributes to reperfusion induced edema in gebril brains. J. Clin. Invest. 81:1556-1562. crossref(new window)

Seo, H.S., B.H. Chung and Y.G. Cho. 2008. Antioxidant and anticancer effects of agrimony (Agrimonia pilosa L.) and chinese lizardtail (Saururus chinenses Baill). Kor. J. Medicinal Crop Sci. 16:139-143 (in Korean).

Shon, M.Y. 2007. Antioxidant and anticancer activities of Poria cocos and Machilus thunbergii fermented with mycelial mushrooms. Food Industry and Nutrition. 12:51-57 (in Korean).

Woo, J.H., H.S. Jeong, J.S. Yu, Y.D. Chang and C.H. Lee. 2008. Antioxidant effect of extracts obtained from four aster species native to korea. Korean J. Plant Res. 21:52-59 (in Korean).

Yen, G.C. and C.L. Hsieh. 1998. Antioxidant activity of extracts from Du-zhong (Eucommia ulmoides) toward various lipid peroxidation models in vitro. J. Agric. Food Chem. 46: 3431-3436 (in Korean). crossref(new window)

Yu, B.P. 1993. Oxidative damage by free radicals and lipid peroxidation in aging. In : Yu B.P. Free radicals in aging. CRC Press, Boca Raton. 57-88.

Zhishen, J., T. Mengcheng and W. Jianming. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64:555-559. crossref(new window)