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Effects of the Actindia chinensis on Loperamide-induced Constipation in Rat
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  • Journal title : Korean Journal of Plant Resources
  • Volume 24, Issue 1,  2011, pp.61-68
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2011.24.1.061
 Title & Authors
Effects of the Actindia chinensis on Loperamide-induced Constipation in Rat
Kim, Dong-Geon; Jin, Young-Geon; Jin, Ju-Youn; Kim, Sang-Cheol; Kim, Seong-Cheol; Han, Chang-Hoon; Lee, Young-Jae;
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 Abstract
Loperamide-induced constipation reduced gastric emptying, small-intestinal and colonic motility, and these effects were prevented by Actindia chinensis(Gold Kiwi Fruit, GKF). In this study, the effects of Actindia chinensis on constipated male Sprague-Dawley rats induced by loperamide(2 mg/kg, s.c.,5 days) were investigated. Rats were randomly assigned to the normal control rats(regular diet), constipated rats(regular diet plus loperamide), constipated rats treated with 2.5% GKF(regular diet supplemented with 2.5% GKF plus loperamide), constipated rats treated with 5% GKF (regular diet supplemented with 5% GKF plus loperamide). There was less fecal excretion and lower fecal water content in loperamide-treated rats than in control rats. Oral administration of GKF blocked the decrease of fecal excretion and fecal water content in the loperamide-treated rats. Mucus production of crypt cell and mucus contents at fecal and mucosa surface were reduced by loperamide-treated rat. But colonic crypt cell contained increased mucin in the GKF treated group and mucus layer stained with alcian blue was significantly thicker in GKF treated rats compared with in loperamide-treated rats. In isolated rat ileum, loperamide produced inhibition of ileal motility. Pretreatment with methanolic extracts of GKF in isolated rat ileum prevented inhibition by loperamide. These findings indicated that the GKF was effective for alleviation of inhibition of colonic peristalsis by loperamide and that GKF might be of value in the prevention of constipation.
 Keywords
Actindia chinensis;Gold kiwi fruit;Constipation;Isolated rat ileum;Loperamide;
 Language
Korean
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 References
1.
Lembo. A. and M. Camilleri. 2003. Chronic constipation. N Engl. J. Med. 349:1360-1368. crossref(new window)

2.
Awouters. F., A. Megens, M. Verlinden, J. Schuurkes, C. Niemegeers and P.A. Jaassen. 1993. Loperamide, survey of studies on mechanism of its antidiarrheal activity. Dig. Dis. Sci. 38:977-995. crossref(new window)

3.
Burleigh. D.E. 1988. Opioid and non-opioid actions of loperamide on cholinergic nerve function in human isolated colon. Eur. J. Pharmacol. 152:39-46. crossref(new window)

4.
Cepinskas. G., R.D. Specian and P.R. Kvietys. 1993. Adaptive cytoprotection in the small intestine:role of mucus. Am. J. Physiol. 264:921-927.

5.
Chen. H.L., V.S. Haack, C.W. Janecky, N.W. Vollendorf and J.A. Marlett. 1998. Mechanism by which wheat bran and oat bran increase stool weight in humans. Am. J. Clin. Nutr. 68:711-719.

6.
Deossman. D.A., J.E. Richter and N.S. Talley. 1994. The functional gastrointestinal disorders. 1st ed., Brown and Company, Boston: Little.

7.
John H.C. 1984. Constipation, dietary fibre and the control of large bowel function. Postgrad Med. J. 60:811-819. crossref(new window)

8.
Kim, HS., BY. Kim. and MH. Kim. 2003. Utility of post-mature kiwi fruit powder in bakery products. J. Kor. Soc. Food Sci. Nutr. 32:581-585 (in Korean). crossref(new window)

9.
Kim. JH., HK. Yang, HJ. Hong, WY. Kang, DG. Kim, SC. Kim, KS. Song, D. King, CH. Han and YJ. Lee. 2010. Neuroprotective effects of Korean kiwifruit against t-BHPinduced cell damage in PC12 cells. J. Korea. Plant Res. 23(2):165-171 (in Korean).

10.
Lee, DH., SC. Lee and YI. Hwang. 2000. Processing properties of kiwifruit treated with protopectinase. J. Kor. Soc. Food Sci. Nutr. 29:401-406 (in Korean).

11.
Lembo A and M. Camilleri. 2003. Chronic constipation. N Engl. J. Med. 349:1360-1368. crossref(new window)

12.
Locke GR III. 1996. The epidemiology of functional gastrointestinal disorders in North America. Gastroenterol. Clin. North Am. 25:1-19.

13.
Matich. A.J., H. Young, J.M. Allen, M.Y. Wang, S. Fielder, M.A. McNeilge and E.A. MacRae. 2003. Actinidia arguta: volatile compounds in fruit and flowers. Phytochemistry 63:285-301. crossref(new window)

14.
Motohashi. N., Y. Shirataki, M. Kawase, S. Tani, H. Sakagami, K. Satoh, T. Kurihara, H. Nakashima, I. Musci, A. Varga and J. Molnar. 2002. Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts. J. Ethnopharmacol. 81:357-364. crossref(new window)

15.
Muller-Lissner. S.A., M.A. Kamm, C. Scarpinato and A. Wald. 2005. Myths and misconceptions about chronic constipation. Am. J. Gastroenterol. 100:231-242.

16.
Nakamura. T., G. Agata, M. Mizutani and H. Iino. 2001. Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats. Biosci. Biotech. Bioch. 65:774-780. crossref(new window)

17.
Oh, JH., KE. Lee, JM. Kim and SC. Lee. 2001. Preparation and chracteristics of whelk internal organ Jeotgal with the addition of fruit juice. J. Kor. Soc. Food Sci. Nutr 30:641-645 (in Korean).

18.
Park. YS., ST. Jung, SG. Kang, J. Drzewiecki, J. Namiesnik, R. Haruenkit, D. Barasch, S. Trakhtenberg. and S. Gorinstein. 2006. In vitro stuides polyphenols, antioxidants and other dietary indices in kiwifruit (Actinidia deliciosa). Int. J. Food Sci. Nutr. 57:107-122. crossref(new window)

19.
Read. N.W. 1983. Speculations on the role of motility in the pathogenesis and treatment of diarrhea. J. Gastroenterol. 84:45-63.

20.
Rush. E.C., M. Patel, L.D. Plank. and L.R. Ferquson. 2002. Kiwifruit promotes laxation in the elderly. Asia Pac J. Clin. Nutr. 11:164-168. crossref(new window)

21.
Schiller. L.R., C.A. Santa Ana, S.G. Moravski. and J.S. Fordtran. 1984. Mechanism of the antidiarrheal effect of loperamide. Gastroenterology 86:1475-1480.

22.
Shimotoyodome. A., S. Meguro, T. Hase, I. Tokimitsu and T. Sakata. 2000. Decreased colonic mucus in rats with loperamide-induced constipation. Comp. Biochem. Physiol. 126(2):203-211. crossref(new window)

23.
Siproudhis. L., F. Pigot, P. Godberge, H. Damon, D. Soudan and M.A. Bigard. 2006. Defecation disorders; a french population survey. Dis. Colon. Rectum 49:219-227. crossref(new window)

24.
Smith. B. 1968. Effect of irritant purgatives on the myenteric plexus in man and the mouse. Gut: an International J. of Gastroenterology and Hepatology 9:139-143.

25.
Smith. B. 1973. Pathologic changes in the colon produced by anthraquinone laxatives. dis. Colon. Rectum 16:455-458. crossref(new window)

26.
Stoll. R., H. Ruppin and W. Domschke. 1988. Calmodulinmediated Calmodulinmediated effects of loperamide on chloride transpor by brush border membrane vesicles from human ileum. Gastroenterology 95:59-76.

27.
Sugiyama, S., K. Ohtsuki, K. Sato and M. Kawabata. 1997. Enzymatic properties, substrate specificities and pHactivity profiles of two kiwifruits proteases. J. Nutr. Sci. Vitaminol. 43:581-589. crossref(new window)

28.
Sugiyama, S., A. Hirota, C. Okada, T. Yorita, K. Sato and K. Ohtsuki. 2005. Effect of kiwifruit juice on beef collagen. J. Nutr. Sci. Vitaminol. 51:27-33. crossref(new window)

29.
Theodoru. V., J. Fioramonti, T. Hachet and L. Bueno. 1991. Absortive and motor components of the antidiarrheal action of loperamide: an in vivo study in pigs. Gut: an International J. of Gastroenterology and Hepatology 11: 1355-1359.

30.
Watanabe. T., N. Nakaya, K. Kurachima, S. Kuriyama, Y. Tsubono and I. Tsuji. 2004. Constipation, Laxative use and risk of colorectal cancer: the Miyagi cohort study. Eur. J. Cancer 40:2109-2115. crossref(new window)

31.
Kim. YS. and GS. Song. 2002. Characteristics of kiwifruitadded traditional Kochujang. Kor. J. food Sci. Technol. 34:1091-1097 (in Korean).

32.
Zhong. Z., W. Zhang, F. Zhang, X. Chen and C. Huang. 2005. Experimental study on the antitumor effects from roots of Actinidia indochinensis in carcinoma cell lines. Zhong Yao Cai 28:215-218.