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Inhibitory Effects of Ginseng Extracts on Histamine-release from Rat's Mast Cell
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  • Journal title : Korean Journal of Plant Resources
  • Volume 24, Issue 1,  2011, pp.98-104
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2011.24.1.098
 Title & Authors
Inhibitory Effects of Ginseng Extracts on Histamine-release from Rat's Mast Cell
Park, Kwang-Hyun; Kim, Young-Seon; Jeong, Jae-Hun;
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We investigated inhibitory effects of ginseng extracts against compound 48/80-induced responses in rat peritoneal mast cells. Initially, we optimized extraction condition with various temperature and time for recovery of high saponin contents in extracts. Using a primary rat peritoneal mast cells, we examined whether ginseng extracts inhibit compound 48/80-induced histamine release form rat mast cells. High red ginseng-spercific saponin containing extracts were recovered at for 48 hr, and had no cytotoxicity with relatively high dose of extracts on rat peritoneal mast cells(<0.5 mg/ml). For examine of ameliorate effects of mast cells responses by ginseng extract, we pre-treated the extracts or saline to mast cells and treated compound 48/80. In results, compound 48/80 treatment was increased histamine release (approximately 30%) from mast cells than normal group, whereas ginseng treatment was completely inhibited histamine release. These results suggested that ginseng extracts inhibits the compound 48/80-induced mast cell activation, and ginseng extracts is a candidate for effective therapeutic tools of allergic diseases.
 Cited by
홍삼의 생체 내 사이토카인 분비에 대한 면역조절효과,손은화;윤재웅;구현정;박대원;정용준;남궁승;한효상;강세찬;

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