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Comparative Study of Litsea japonica Leaf and Fruit Extract on the Anti-inflammatory Effects
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 2,  2015, pp.145-152
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.2.145
 Title & Authors
Comparative Study of Litsea japonica Leaf and Fruit Extract on the Anti-inflammatory Effects
Namkoong, Seung; Jang, Seon-A; Sohn, Eun-Hwa; Bak, Jong Phil; Sohn, Eunsoo; Koo, Hyun Jung; Yoon, Weon-Jong; Kwon, Jung-Eun; Jeong, Yong Joon; Meng, Xue; Han, Hyo-Sang; Kang, Se Chan;
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The present study aimed to investigate comparative anti-inflammatory effects of Litsea japonica fruit and leaf extract considering the balance of safety and efficacy. Dose response studies were performed to determine the inhibitory effects of 70% EtOH extract of leaf (L70%) on the pro-inflammatory enzymes expression, COX-2/PGE2 and NO/iNOS, and pro-inflammatory cytokines production, IL-, IL-6, and TNF- in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. We also examined comparative effects of 30 and 70% EtOH extract of fruits (F30% and F70%) at low concentration ( ) in the same conditions. L70% at 50 and showed inhibitory effects on almost all the inflammatory mediators we examined except for COX-2 regulation, but there were no effects at . Since of L70% have 18.2% cytotoxicity, we compared the effects of fruit extract, F30% and F70% at on the regulation of NO/iNOS, PGE2, IL-, IL-6, and TNF- and obtained that fruit extacts are more efficacious and safe than leaf. This study suggests that the 30% EtOH fraction of L. japonica fruit could be a good candidate for development as a functional food supplement in the prevention of inflammatory disorders.
Anti-inflammatory;Fruit;Leaf;Lipopolysaccharide;Litsea japonica;
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