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Anti-Obesity Effect of By-Product from Soybean on Mouse Fed a High Fat Diet
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 2,  2015, pp.168-177
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.2.168
 Title & Authors
Anti-Obesity Effect of By-Product from Soybean on Mouse Fed a High Fat Diet
Park, Young Mi; Lim, Jae Hwan; Seo, Eul Won;
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Here we study the anti-obesity effects of by-product from soybean on mouse fed high fat diet. The body weight gain, visceral and subcutaneous adipose tissue weight, liver and epididymal adipose tissue weight in freeze-dried soybean-soaking-water (SSW) powder fed group showed lower level than those in high fat diet (HFD) group by determining with weight measuring and histological methods. Also, histological analyses of the liver and fat tissues of SSW grouped mice revealed significantly less number of lipid droplets formation and smaller size of adipocytes compared to the HFD group. Moreover, the levels of total serum cholesterol, LDL-cholesterol and the atherogenic index were decreased in the SSW groups. Especially, in SSW group, the levels of phosphorylation of two lipid oxidation enzymes, adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylasse (ACC) were elevated hence that may activate fatty acid oxidation. But AST and ALT levels were not changed in blood. By micro-CT analysis of abdomen, SSW groups significantly showed a tendency to decrease visceral and subcutaneous fats as well as fat-deposited areas compared to HFD group. Taken together, we suggest that soybean soaking water has a function in ameliorating obesity through inhibiting lipid synthesis as well as stimulating fatty acid oxidation.
Soybean curd whey;Soybean soaking water;Micro-CT;Lipid metabolism;Anti-obesity;
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Adlercreutz, H., Y. Mousavi, J. Clark, K. Hockerstedt, E. Hamalainen, K. Wahala, T. Makela and T. Hase. 1992. Dietary phytoestrogens and cancer: in vitro and in vivo studies. J. Steroid Biochem. Mol. Biol. 41:331-337. crossref(new window)

Ahn, I.S., K.Y. Pack and M.S. Do. 2007. Weight control mechanisms and antiobesity functional agents. J. Korean Soc. Food Sci. Nutr. 36:503-513 (in Korean). crossref(new window)

Anne, W.H. and B.H. Joyce. 2001. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am. J. Physiol. Cell Physiol. 280:C807-C813.

Bae, E.A., T.W. Kwon and G.S. Moon. 1997. Isoflavone contents and antioxidative effects of soybean, soybean curd and their by-products. J. Korean Soc. Food Sci. Nutr. 26:371-375 (in Korean).

Biorntorp, P. 1988. The associations between obesity, adipose tissue distribution and disease. Acta. Med. Scand. 723:121-134.

Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254. crossref(new window)

Chen, J.R., S.F. Chiou, K. Suetsuna, H.Y. Yang and S.C. Yang. 2003. Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non dialyzed soybean protein fraction. Nutrition 19:676-680. crossref(new window)

Chin, H.S., K.J. Pack, S.H. Pack and J.K. Kim. 2009. The effects of herbal extract mixture on anti-obesity. J. Korean Soc. Food Sci. Nutr. 38:32-38 (in Korean). crossref(new window)

Choi, Y.B., K.S. Kim and H.S. Sohn. 1995. Recovery of soy-oligosaccharides using calcium oxide. J. Food Sci. 27:225-229 (in Korean).

Despres, J.P. 1993. Abdominal obesity as important component of insulin-resistant syndrome. Nutrition 19:452-459.

Friedewald, W.T., R.I. Levy and D.S. Fredrickson. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18:499-502.

Frings, C.S. and R.M. Dunn. 1970. A colorimetric method for determination of total serum lipids based on the sulfo-phospho-vanillin reaction. Am. J. Clin. Pathol. 53:89-91.

Galvez, A.F. and B.O. de Lumen. 1999. A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells. Nat. Biotechnol. 17:495-500. crossref(new window)

Hackler, L.R. and B.R. Stillings. 1967. Amino acid compostion of heat-processed soymilk and its correlation with nutritive value. Cereal Chem. 44:70-77.

Kaufman, P.B., J.A. Duke, H. Brielmann, J. Boik and J.E. Hoyt. 1997. A comparative survey of leguminous plants as sources of the isoflavones, genistein and daidzein: implications for human nutrition and health. J. Altern. Complement Med. 3:7-12. crossref(new window)

Kim, A.R., J.J. Lee, S.S. Cha, H.C. Chang and M.Y. Lee. 2012. Effect of soybeans, chungkukjang, and doenjang on blood glucose and serum lipid profile in streptozotocin-induced diabetic rats. J. Korean Soc. Food Sci. Nutr. 41:621-629 (in Korean). crossref(new window)

Kim, K.S., H.K. Chun and H.S. Sohn. 1994. Purification of oligosaccharides from soybean using activated charcoal. Korean J. Food Sci. Technol. 3:156-156 (in Korean).

Kim, K.S., J.H. Hong and D.I. Kim. 2012. Anti-obesity effects of capsule-filled cheonggukjang added with arrowroot (Pueraria thunbergiana) extracts in ob/ob mice. J. Korean Soc. Food Sci. Nurt. 41:782-789 (in Korean). crossref(new window)

Koo, H.J., S.C. Kang, S.A. Jang, J.E. Kwon, E.S. Sohn and E.H. Sohn. 2014. Effects of protocatechuic acid derived from Rubus coreanus on the lipid metabolism in high cholesterol diet induced mice. Korean J. Plant Res. 27:271-278 (in Korean). crossref(new window)

Kopelman, P.G. and L. Albon. 1997. Obesity, non-insulin-dependent diabetes mellitus and the metabolic syndrome. Brit. Med. Bull. 53:322-340. crossref(new window)

Lee, H.S., J.H. Choi, Y.E. Kim and C.H. Lee. 2012. Effect of dietary intake of Salicornia herbacea L. hot water extract on anti-obesity in diet-induced obese rats. J. Korean Soc. Food Sci. Nutr. 41:950-956 (in Korean). crossref(new window)

Lew, E.A. 1985. Mortality and weight: insured lives and the american cancer society studies. Ann. Intern. Med. 103:1024-1029. crossref(new window)

Matsumoto, K., Y. Watanabe and S. Yokoyama. 2007. Okara, soybean residue, prevents obesity in a diet-induced murine obesity model. Biosci. Biotechnol. Biochem. 71:720-727. crossref(new window)

McGee, D.L. 2005. Body mass index and mortality: a meta-analysis based on person-level data from twenty-six observational studies. Ann. Epidemiol. 15:87-97. crossref(new window)

Noma, A., K. Nezu-Nakayama, M. Kita and H. Okabe. 1978. Simultaneous determination of serum cholesterol in high- and low-density lipoproteins with use of heparin, Ca2+, and an anion-exchange resin. Clin. Chem. 24:1504-1508.

Potter, S.M. 1995.Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J. Nutr. 125:606S-611S.

Reitman, S. and S.A. Frankel. 1957. Colorimetric method for determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28:56-63.

Richmond, W. 1976. Use of cholesterol oxidase for assay of total and free cholesterol in serum by continuous flow analysis. Clin. Chem. 22:1579-1588.

Ruderman, N.B, A.K. Saha, D. Vavvas and L.A. Witters. 1999. Malonyl-CoA, fuel sensing, and insulin resistance. Am.J. Physiol. 276:1-18.

Saha, A.K.R.N. 2003. Malonyl-CoA and AMP-activated protein kinase: An expanding partnership. Mol. Cell Biochem. 253:65-70. crossref(new window)

Sharma, O.P., H. Adlercreutz, J.D. Strandberg, B.R. Zirkin, D.S. Coffey and L.L. Exing. 1992. Soy of dietary source playsd a preventive role against the pathogenesis of prostatitis in rats. J. Steroid. Biochem. Mol. Biol. 43:557-564. crossref(new window)

Sollof, L.A., H.L. Futenberg and A.G. Lacko. 1973. Serum cholesterol esterfication in patients with coronary artery disease. Am. Heart J. 85:153-161. crossref(new window)

Villanueva, M.J., W.H. Yokoyama, Y.J. Hong, G.E. Barttley and P. Rupérez. 2011. Effect of high-fat diets supplemented with okara soybean by-product on lipid profiles of plasma, liver and faeces in syrian hamsters. Food Chem. 124:72-79. crossref(new window)

Wat, E., S. Tandy, E. Kapera, A. Kamili, R.W.S. Chung, A. Brown, A. Brown, M. Rowney and J.S. Cohn. 2009. Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high fat diet. Atherosclerosis 205:144-150. crossref(new window)

Wei, H.L., F. Frenkel, R. Browen and S. Barnes. 1993. Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutr. Cancer 20:1-20. crossref(new window)

Won, C.U., Y.S. Jung, K.H. Yoon, H.Y. Lee, M.C. Yoon, B.K. Kim, S.D. Park and S.S. Shin. 2008. Herba ephedrae and Rhizoma amorphophalli modulates visceral obesity in micro-CT of high fat induced obese male mice. J. Korean Ori. Med. Pres. 16:205-217 (in Korean).