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Anti-Obesity Effect of By-Product from Soybean on Mouse Fed a High Fat Diet
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 2,  2015, pp.168-177
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.2.168
 Title & Authors
Anti-Obesity Effect of By-Product from Soybean on Mouse Fed a High Fat Diet
Park, Young Mi; Lim, Jae Hwan; Seo, Eul Won;
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Here we study the anti-obesity effects of by-product from soybean on mouse fed high fat diet. The body weight gain, visceral and subcutaneous adipose tissue weight, liver and epididymal adipose tissue weight in freeze-dried soybean-soaking-water (SSW) powder fed group showed lower level than those in high fat diet (HFD) group by determining with weight measuring and histological methods. Also, histological analyses of the liver and fat tissues of SSW grouped mice revealed significantly less number of lipid droplets formation and smaller size of adipocytes compared to the HFD group. Moreover, the levels of total serum cholesterol, LDL-cholesterol and the atherogenic index were decreased in the SSW groups. Especially, in SSW group, the levels of phosphorylation of two lipid oxidation enzymes, adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylasse (ACC) were elevated hence that may activate fatty acid oxidation. But AST and ALT levels were not changed in blood. By micro-CT analysis of abdomen, SSW groups significantly showed a tendency to decrease visceral and subcutaneous fats as well as fat-deposited areas compared to HFD group. Taken together, we suggest that soybean soaking water has a function in ameliorating obesity through inhibiting lipid synthesis as well as stimulating fatty acid oxidation.
Soybean curd whey;Soybean soaking water;Micro-CT;Lipid metabolism;Anti-obesity;
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