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A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 4,  2015, pp.371-381
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.4.371
 Title & Authors
A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats
Kim, Min-Kyeoung; Lee, Ji Sun; Park, Yeong Chul; Choi, Sun Mi; Lee, Sanghun;
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 Abstract
The object of this study was to obtain single oral dose toxicity of Arisaema Rhizome (Arisaema amurense f. serratum (Nakai) Kitag) aqueous extracts. Arisaema Rhizome (Chunnamsong in Korean) is one of the most important folk remedy plants used in Asia. In the study, a 28-day rat oral gavage study has been conducted with the extracts from Arisaema Rhizome at dose of 1,250, 2,500 and 5,000 ㎎/㎏/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000 ㎎/㎏/day of the water-extracts from Arisaema Rhizome.
 Keywords
Arisaema Rhizome;Toxicity test;NOEL;NOAEL;Folk remedy;
 Language
Korean
 Cited by
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