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A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 4,  2015, pp.371-381
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.4.371
 Title & Authors
A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats
Kim, Min-Kyeoung; Lee, Ji Sun; Park, Yeong Chul; Choi, Sun Mi; Lee, Sanghun;
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The object of this study was to obtain single oral dose toxicity of Arisaema Rhizome (Arisaema amurense f. serratum (Nakai) Kitag) aqueous extracts. Arisaema Rhizome (Chunnamsong in Korean) is one of the most important folk remedy plants used in Asia. In the study, a 28-day rat oral gavage study has been conducted with the extracts from Arisaema Rhizome at dose of 1,250, 2,500 and 5,000 ㎎/㎏/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000 ㎎/㎏/day of the water-extracts from Arisaema Rhizome.
Arisaema Rhizome;Toxicity test;NOEL;NOAEL;Folk remedy;
 Cited by
Bensky, D. and A. Gamble. 1986. Chinese Herbal Medicine - Revised Edition. Eastland Press, Seattle, WA (USA).

Chang, I.K and N.D. Hong. 1985. Experimental studies on the acute toxicity and the efficacy of phyllostachys juice. Korean J. Orient. Int. Med. 2:83-101.

Choi, H.K., H.S. Roh, J.Y. Jeong and H.Y. Ha. 2014. Acute oral toxicity of Atractylodes macrocepala KOIDZ. Korean J. Plant Res. 27(1):11-21 (in Korean). crossref(new window)

Dourish, C.T. 1987. Effects of drugs on spontaneous motor activity: In Greenshaw, A.J. and C.T. Dourish (eds.), Experimental Psychopharmacology. Humana Press. Clifton, New York (USA). pp. 325-334.

Gu, J.H., S.R. Kim, J.W. Lee, M.Y. Park, H.Y. Choi and J.D. Kim. 2011. Mouse single oral dose toxicity test of Taraxaci Herba aqueous extracts. J. of Oriental Medical Pathology 25(4):650-657.

Hong, M.K., J.O. Park and S.J. Wang. 2003. A case of toxicity caused by Arisaematis Rhizoma ingestion. J. The Korean Society of Clinical Toxicology 1(1): 40-42.

Huaug, K.C. 1999. The Pharmacology of Chinese Herb II. CRC press, Boca Raton (USA).

Hwang, S.Y., W. Kwon, H.Y. Chai, Y.M. Cho, N.J. Lee, J.M. Ryu, J.S, Sin, T.M. Kim, J.H. Cho, E.J.Kim, J.H. Pakr, J.K. Kang and Y.B. Kim. 2004. Four-week repeated-dose toxicity study on Mori Raddiceis cortex. The Korean Journal of Laboratory Animal Sci. 20(3):203-290.

Irwin, S. 1968.Comprehensive observational assessment: Ia. A systemic, quantitative procedure for assessing the behavioral and physiological state of the mouse. Psychopharmacology 13:222-257. crossref(new window)

Jang, I.Y. 2003. Treaties on Asian Herbal Medicines I. Natural Products Research Institute, Seoul National University Press, Korea. pp. 401-402.

Jeon, H. 2000. Effect of Arisaematis Rhizoma on the proliferation of transplanted - L1210 cells in Mice. Kor. J. Herbology 15(2):9-16

Jing, J.H., C.O. Lee, Y.C. Kim and S.S. Kang. 1996. New bioctive cerebrosides from arisaema amurense. J. Nat. Prod. 59:319-322. crossref(new window)

Korea Food and Drug Administration. 2005. Testing guidelines for safety evaluation of drugs, notification No. 2005-60. Korea Food and Drug Administration, Seoul, Korea.

Lee, L.E., H.J. Kim, E.K. Choi, H.Y. Chai, Y.W. Yun, D.J. Kim and S.Y. Nam. 2003. Four-week repeated-dose toxicity study on Pinellia Extract. Korean J. Lab. Anim. Sci. 19:127-153.

Oh, T.W., H.S. Bae, C.H. Yoon and Y.K. Park. 2010. Thirteenweek repeated-dose oral taxicity study of the modified Wenpitang-Hab-Wulingsan (WHWⓇ) in sprague-dawly rats. Korean Journal of Herbol. 25(3):43-51.

Park, Y.C.,J.S. Lee, D.Y. Kim, H.Y. Son, J.W. Lee, Y.S. Chei, K.K. Kim, C.Y. Yu, I.M. Chung, M.H. Im, K.J. Lee, R.N. Choi, H.S. Shim and J.D. Lim. 2013. A 90 day repeated dose-oral toxicity study of extracts from Astragalus membranaceus-Aboveground parts in rats. Korean J. Medicinal Crop Sci. 21(6):474-485. crossref(new window)

Yoo, T.W., B.I. Kim, J.B. Kim, D.J. Kim, J.W. Kim, S.K. Baik, K.S. Kim and G.J. Cheon. 2007. Survey for the actual condition of drug medication and development of health care cost associated with toxic liver injury in Korean: A multicenter study for the detection and the development of nationwide reporting system of toxic. Clinical and Molecular Hepatology 13:34-43.

Yoo, H.J., M.Y. Park, H.Y. Choi and J.D. Kim. 2010. Mouse single oral dose toxicity test of Lonicerae Flos aqueous extracts. Korean J. Oreiental Med. 31(3):539-53.