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Inhibitory Effects of Extracts from Arabis glabra on Lipopolysaccharide Induced Nitric Oxide and Prostaglandin E2 Production in RAW264.7 Macrophages
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 5,  2015, pp.568-573
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.5.568
 Title & Authors
Inhibitory Effects of Extracts from Arabis glabra on Lipopolysaccharide Induced Nitric Oxide and Prostaglandin E2 Production in RAW264.7 Macrophages
Nam, Jung-Hwan; Seo, Jong-Taek; Kim, Yul-Ho; Kim, Ki-Deog; Yoo, Dong-Lim; Lee, Jong-Nam; Hong, Su-Young; Kim, Su-Jeong; Sohn, Hwang-Bae; Kim, Hyun-Sam; Kim, Bo-Sung; Shin, Ji-Sun; Lee, Kyung-Tea; Park, Hee-Jhun;
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Arabis glabra is a localized common rhizomatous flowering plant, This plant is often used in Korean traditional systems of medicine as a remedy for blood cleaning, detoxification, abscess, gastrospasm, arthritis, contraction and diarrhea. Generally drugs that are used for arthritis have antinociceptive and anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of A. glabra using the ethanolic extract and its sub-fractions. To evaluate the anti-inflammatory effects, we examined the inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) on RAW 264.7macrophages. Our results indicated that hexane and chloroform fraction significantly inhibited the LPS-induced NO and PGE2 production in the cells. The hexane fraction inhibitory activity for NO tests with IC50 values showed in 21.0 ㎍/㎖. The chloroform fraction inhibitory activity for PGE2 tests with IC50 values showed in 18.0 ㎍/㎖. These efficacy are expected to be able to present the potential for the development of health functional food for the prevention inflammatory diseases because it has sufficient preventive medical possibilities. Further, it is determined that it is necessary to further study the mechanism of cytokine and protein expression associated with inflammation.
Anti-inflammatory;Anti-inflammatory effect;Nitric oxide (NO);Prostaglandin E2 (PGE2);RAW 264.7 cells;
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