JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Anti-osteoarthritis Effects on Fruit Extract of Litsea japonica
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 5,  2015, pp.591-599
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.5.591
 Title & Authors
Anti-osteoarthritis Effects on Fruit Extract of Litsea japonica
Yoon, Weon-Jong; Song, Sang Mok; Ham, Young-Min; Oh, Dae-Ju; Ko, Chang-Sik; Yoon, Sun-A; Lee, Yong-Bum; Park, Dae Won; Jeong, Yong Joon; Kwon, Jung Eun; Cho, Young-Mi; Cho, Ju-Hyun; Kim, Chang-Sook; Kang, Se Chan;
  PDF(new window)
 Abstract
Osteoarthritis (OA) is a degenerative disease characterized by the progressive degradation of joint cartilage and is accompanied by secondary inflammation of synovial membranes. The purpose of this study describes a preliminary evaluation of the anti-inflammatory activity on test material of Litsea japonica. fruit (LJTM) Also, this study was to evaluate the effects of LJTM on the joint cartilage of rat with OA induced by monosodium iodoacetate (MIA). To study for anti-inflammatory agents effectively, we first examined the inhibitory effect of the LJTM on the production of pro-inflammatory factors and cytokines stimulated with lipopolysaccharide. We identified anti-nociceptive effects of the LJTM by using in vivo peripheral and central nervous pain models. In addition, the aim of this study was to evaluate the effects on mRNA expression of MMP-2, -3, -7, -9, -13, TIMP-1 and –2 in cartilage of OA. In the LJTM inhibited production of pro-inflammatory mediators (NO and PGE2) and pro-inflammatory cytokines (TNF-α and IL-6). In cartilage, Expression of MMPs and TIMPs mRNA was suppressed in LJTM treatment group than in the control group. This study suggests that LJTM are potential candidates as anti-inflammation and anti-osteoarthritis agents (painkillers) for the treatment of OA.
 Keywords
Osteoarthritis;Litsea japonica fruit;Inflammation;Monosodium iodoacetate;mRNA expression;
 Language
Korean
 Cited by
 References
1.
Altman, R., E. Asch and D. Bloch. 1986. The American Collage of Rheumatology criteria for the classification and reporting of osteoarthritis of the knee. Arthritis Rheuma. 26:1039-1049.

2.
Dannerman, P.J. 1977. In Monitoring of analgesia in anesthesia and analgesia in laboratory animals. Academic Press. USA. pp. 83-99.

3.
Ding, C., F. Cicuttini, J. Li and G. Jones, 2009. Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. Expert. Opin. Investig. Drugs. 18:1457-1466. crossref(new window)

4.
Guzmán-Gutiérrez, S.L., R. Gómez-Cansino, J.C. García-Zebadúa, N.C. Jiménez-Pérez and R. Reyes-Chilpa. 2012. Antidepressant activity of Litsea glaucescens essential oil: identification of β-pinene and linalool as active principles. J. Ethnopharmacol. 143:673-9. crossref(new window)

5.
Heo, S.J., W.J. Yoon, K.N. Kim, G.N. Ahn, S.M. Kang, D.H. Kang, A. Affan, C. Oh, W.K. Jung and Y.J. Jeon. 2010. Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chem. Toxicol. 48:2045-2051. crossref(new window)

6.
Jiménez-Pérez, N., N. Jiménez-Pérez, C. del, F.G. Lorea-Hernández, C.K. Jankowski and R. Reyes-Chilpa. 2011. Essential oils in Mexican Bays (Litsea spp., Lauraceae): taxonomic assortment and ethnobotanical implications. Econ. Bot. 65:178–89. crossref(new window)

7.
Jin, S.Y., S.S. Kang, D.W. Lee, S.J. Yim, Y.H. Yun and B.I. Lee. 2001. Expression of matrix metalloproteinase (MMP)-1, MMP-3 nitrotyrosine and apoptosis in articular catilage of human osteoarthritis. Korean J. Pathol. 35:31-29.

8.
Kim, J.Y., K.S. Jung and H.G. Jeong. 2004. Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. FEBS Lett. 56:321-326.

9.
Kim, E.Y. and K.D. Moudgil. 2008. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol. Lett. 120:1-5. crossref(new window)

10.
Kim, J.H., R.A. Bachmann and J. Chen. 2009 Interleukin-6 and insulin resistance. Vitam. Horm. 80:613-633. crossref(new window)

11.
Koo, HJ, W.J. Yoon, E.H. Sohn, Y.M. Ham, S.A. Jang, J.E. Kwon, Y.J. Jeong, J.H. Kwak, E. Sohn, S.Y. Park, K.H. J, S. Namkoong, H.S. Han, Y.H. Jung and S.C. Kang. 2014. The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-κB and JNK/p38 MAPK activation. Int. Immunopharmacol. 22:84-97. crossref(new window)

12.
Kraus, V.B. 1997. Pathogenesis and treatment of osteoarthritis. Med. Clinics North Am. 81:85-112. crossref(new window)

13.
Lee, H.J., E.A. Hyun, W.J. Yoon, B.H. Kim, M.H. Rhee, H.K. Kang, J.Y. Cho and E.S. Yoo. 2006. In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. J. Ethnopharmacol. 103:208-216. crossref(new window)

14.
Martel-Pelletier, J., R. McCollum, N. Fujimoto, K. Obata, J.M. Cloutier and J.P. Pelletier. 1994. Excess of metalloproteinases over tissue inhibitor of metalloproteinase may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. Lab. Invest. 70:807-15.

15.
McDaniel M.L., G. Kwon, J.R. Hill, C.A. Marshall and J.A. Corbett. 1996. Cytokines and nitric oxide in islet inflammation and diabetes. Proc. Soc. Exp. Biol. Med. 211:24-32. crossref(new window)

16.
Min, B.S., S.Y. Lee, J. H. Kim, O.K. Kwon, B.Y. Park, R.B. An, J.K. Lee, H.I. Moon, T.J.,Kim, Y.H. Kim, H. Joung and H.K. Lee. 2003. Lactones from the leaves of the Litsea japonica and their anti-complement activity. J. Nat. Prod. 66:1388-1390. crossref(new window)

17.
Moncada, S., R.M. Palmer and E.A. Higgs. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142.

18.
Mu, M.M., D. Chakravortty, T. Sugiyama, N. Koide, K. Takahashi, I. Mori, T. Yoshida and T. Yokochi. 2001. The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. J. Endotoxin. Res. 7:431-438. crossref(new window)

19.
Murakami, A. and H. Ohigashi. 2007. Targeting NOX, iNOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int. J. Cancer. 121:2357-2363. crossref(new window)

20.
Namkoong, S., S.A. Jang, E.H. Sohn, J.P. Bak, E. Sohn, H.J. Koo, W.J. Yoon, J.E. Kwon, Y.J. Jeong, X. Meng, H.S. Han and S.C. Kang. 2015. Comparative study of Litsea japonica leaf and fruit extract on the anti-inflammatory Effects. Korean J. Plant Res. 28:145-152. crossref(new window)

21.
Ren, K. and R. Torres. 2009. Role of interleukin-1beta during pain and inflammation. Brain. Res. Rev. 60:57-64. crossref(new window)

22.
Ryu, J.H., H. Ahn, J.Y. Kim and Y.K. Kim. 2003. Inhibitory activity of plant extracts on nitric oxide synthesis in LPSactivated macrophage. Phytother. Res. 17:485-489. crossref(new window)

23.
Takeda, K., K. Sakurawi and H. Ishii. 1972. Components of the Lauraceae family-l. New lactonic compounds from Litsea japonica. Tetrahedron 28:3757-3766. crossref(new window)

24.
Tanaka, H., T. Nakamura and K. Ichino. 1990. Butanolides from Litsea japonica. Phytochemistry 29:857-859. crossref(new window)

25.
Tizard, I.R. 1986. Immunology: An introduction inflammation. 2nd ed., Saunders College Publishing, New York, USA. pp. 423-441.

26.
Wearing, S.C., E.M. Henning, N.M. Byrne, J.R. Steele, A.P. Hills. 2006. Musculoskeletal disorders associated with obesity: a biomechanical perspective. Obes. Rev. 7:239-250. crossref(new window)

27.
Yoon, W.J., J.Y. Moon, G. Song, Y.K. Lee, M.S. Han, J.S. Lee, B.S. Ihm, W.J. Lee, N.H. Lee and C.G. Hyun. 2010. Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. Food. Chem. Toxicol. 48:1222-1229. crossref(new window)