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Anti-osteoarthritis Effects on Fruit Extract of Litsea japonica
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 5,  2015, pp.591-599
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.5.591
 Title & Authors
Anti-osteoarthritis Effects on Fruit Extract of Litsea japonica
Yoon, Weon-Jong; Song, Sang Mok; Ham, Young-Min; Oh, Dae-Ju; Ko, Chang-Sik; Yoon, Sun-A; Lee, Yong-Bum; Park, Dae Won; Jeong, Yong Joon; Kwon, Jung Eun; Cho, Young-Mi; Cho, Ju-Hyun; Kim, Chang-Sook; Kang, Se Chan;
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Osteoarthritis (OA) is a degenerative disease characterized by the progressive degradation of joint cartilage and is accompanied by secondary inflammation of synovial membranes. The purpose of this study describes a preliminary evaluation of the anti-inflammatory activity on test material of Litsea japonica. fruit (LJTM) Also, this study was to evaluate the effects of LJTM on the joint cartilage of rat with OA induced by monosodium iodoacetate (MIA). To study for anti-inflammatory agents effectively, we first examined the inhibitory effect of the LJTM on the production of pro-inflammatory factors and cytokines stimulated with lipopolysaccharide. We identified anti-nociceptive effects of the LJTM by using in vivo peripheral and central nervous pain models. In addition, the aim of this study was to evaluate the effects on mRNA expression of MMP-2, -3, -7, -9, -13, TIMP-1 and –2 in cartilage of OA. In the LJTM inhibited production of pro-inflammatory mediators (NO and PGE2) and pro-inflammatory cytokines (TNF-α and IL-6). In cartilage, Expression of MMPs and TIMPs mRNA was suppressed in LJTM treatment group than in the control group. This study suggests that LJTM are potential candidates as anti-inflammation and anti-osteoarthritis agents (painkillers) for the treatment of OA.
Osteoarthritis;Litsea japonica fruit;Inflammation;Monosodium iodoacetate;mRNA expression;
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