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Safflower Bud Dietary Prevents Ovariectomy-induced Osteoporosis in Rats
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  • Journal title : Korean Journal of Plant Resources
  • Volume 28, Issue 6,  2015, pp.704-709
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2015.28.6.704
 Title & Authors
Safflower Bud Dietary Prevents Ovariectomy-induced Osteoporosis in Rats
Choi, Joo Hee; Lim, Seul Ki; Jang, Ah Ra; Nho, Jong Hyun; Lim, Jae Oh; Cho, Seong Kang; Kim, Young Kuk; Lee, An Chul; Choi, Mi Young; Boo, Young Min; Park, Soo Hyun;
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Safflower (Carthamus tinctorius L.) seeds have long been clinically used in Korea to promote bone formation and prevent osteoporosis. In addition, the safflower buds (SB) were found to have more useful functional ingredients than safflower seed. Thus, we investigated the preventive effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E2 10 μg/kg, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 3%) to OVX rats markedly increased trabecular formation in femur compared to OVX rats. Feeding of SB diet (0.3% or 3%) to OVX rats also decreased TRAP activity compared to OVX rats. These results suggest that SB diets have bone sparing effects by the decrease of osteoclast activity. We also observed that OVX rats fed with SB diet (0.3% or 3%) exhibited the decrease of calcium and phosphorus in serum compared to OVX-induced rats. Therefore, SB may be beneficial for the patients of osteoporosis, especially in postmenopausal women.
Ovariectomized rats;Safflower bud;Osteoporosis;Osteoclast;
 Cited by
Alam, M.R., S.M. Kim, J.I. Lee, S.K. Chon, S.J. Choi, I.H. Choi and N.S. Kim. 2006. Effects of safflower seed oil in osteoporosis induced-ovariectomized rats. Am. J. Chin. Med. 34:601-612. crossref(new window)

Bae, S.J., S.M. Shim, Y.J. Park, J.Y. Lee, E.J. Chang and S.W. Choi. 2002. Cytotoxicity of phenolic compounds isolated from seeds of safflower (Carthamus tiractorious L.) on cancer cell lines. Food Sci. Biotechnol. 11:140-146.

Brennan, O., J.S. Kuliwaba, T.C. Lee, I.H. Parkinson, N.L. Fazzalari, L.M. McNamara and F.J O'Brien. 2012. Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis. Calcif. Tissue Int. 91:440-449. crossref(new window)

Cauley, J.A., D.E. Thompson, K.C. Ensrud, J.C. Scott and D. Black. 2000. Risk of mortality following clinical fractures. Osteoporos. Int. 11:556-561. crossref(new window)

Cummings, S.R. and L.J. Melton. 2002. Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761-1767. crossref(new window)

Hiramatsu, M., T. Takahashi, M. Komatsu, T. Kido and Y. Kasahara. 2009. Antioxidant and neuroprotective activities of Mogami-benibana (safflower, Carthamus tinctorius L.). Neurochem. Res. 34:795-805. crossref(new window)

Holzer, G., H. Noske, T. Lang, L. Holzer and U. Willinger. 2005. Soluble cathepsin K: a novel marker for the prediction of nontraumatic fractures? J. Lab. Clin. Med. 146(1):13-17. crossref(new window)

Kalu, D.N. 1991. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15(3):175-191. crossref(new window)

Kim, H.J., D.S. Sim and E.H. Sohn. 2014. Anti-osteoporotic effects of unripe fructus of Rubus coreanus Miquel in osteoblastic and osteoclastic cells. Korean J. Plant Res. 27(6):593-600. crossref(new window)

Kim, H.Y., C.S. Kim, G.J. Jhon, I.S. Moon, S.H. Choi, K.S. Cho, J.K. Chai and C.K. Kim. 2002. The effect of safflower seed extract on periodontal healing of 1-wall intrabony defects in beagle dogs. J. Periodontol. 73:1457-1466. crossref(new window)

Lelovas, P.P., T.T. Xanthos, S.E. Thoma , G.P. Lyritis and I.A. Dontas. 2008. The laboratory rat as an animal model for osteoporosis research. Comp. Med. 58:424-430.

Kneissel., M., N.H. Luong-Nguyen, M. Baptist, R. Cortesi, S. Zumstein-Mecker, S. Kossida, T. O`Reilly, H. Lane and M. Susa. 2004. Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts. Bone 35(5):1144-1156. crossref(new window)

Osterhoff, G., G. Diederichs, A. Tami, J. Theopold, C. Josten and P. Hepp. 2012. Influence of trabecular microstructure and cortical index on the complexity of proximal humeral fractures. Arch. Orthop. Trauma. Surg. 132(4):509-515. crossref(new window)

Qin, D.W., Z. Gu, L. Dai and C. Ji. 2013. Protective effects of gallium, germanium, and strontium against ovariectomized osteoporosis in rats. Biol. Trace Elem. Res. 153(1-3):350-354. crossref(new window)

Rahman, M.M., G. Fernandes and P. Williams. 2014. Conjugated linoleic acid prevents ovariectomy-induced bone loss in mice by modulating both osteoclastogenesis and osteoblastogenesis. Lipids 49(3):211-24. crossref(new window)

Seo, H.J., J.H. Kim, D.Y. Kwak, S.M. Jeon, S.K. Ku, J.H. Lee, K.D. Moon and M.S. Choi. 2000. The effects of safflower seed powder and its fraction on bone tissue in rib-fractured rats during the recovery. Korean J. Nutr. 33:441-420 (in Korean).

Wensel, T.M., M.M. Iranikhah and T.W. Wilborn. 2011. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. Pharmacotherapy 31(5):510-523. crossref(new window)

Yogesh, H.S., V.M. Chandrashekhar, H.R. Katti, S. Ganapaty, H.L. Raghavendra, G.K. Gowda and B. Goplakhrishna. 2011. Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats. J. Ethnopharmacol. 134(2):334-338. crossref(new window)