Advanced SearchSearch Tips
HPLC Analysis on the Cafffeoylquinic Acids of Aster altaicus var. uchiyamae Kitamura and Peroxynitrite-scavenging Effect
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Plant Resources
  • Volume 29, Issue 1,  2016, pp.20-25
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2016.29.1.020
 Title & Authors
HPLC Analysis on the Cafffeoylquinic Acids of Aster altaicus var. uchiyamae Kitamura and Peroxynitrite-scavenging Effect
Lim, Sang-Cheol; Park, Hee-Juhn;
  PDF(new window)
Five caffeoylquinic acids of Aster altaicus var. uchiyamae Kitamura (Compositae) leaves were identified using standard compounds by HPLC and determined as follows: 3,4-di-O-caffeoylquinic acid (4.92 ± 0.06 ㎎/g dried weight), 3,5-di-O-caffeoylquinic acid (3.95 ± 0.13 ㎎/g), 4,5-di-O-caffeoylquinic acid (1.39 ± 0.10 ㎎/g), 5-O-caffeoylquinic acid (chlorogenic acid, 8.05 ± 0.21 ㎎/g), 3-O-caffeoylquinic acid (4.97 ± 0.18 ㎎/g). The total content of five caffeoylquinic acids were calculated as 26.73 ± 0.26 ㎎/g dried weight while the percentage of the five compounds in the MeOH extract was calculated as 25.22 ± 0.25%. The IC50 value of the MeOH extract scavenging peroxynitrite (ONOO) was shown as 5.16 ± 0.15 ㎍/㎖.
Aster altaicus;Compositae;Caffeoylquinic acid;Peroxynitrite;HPLC;
 Cited by
Choi, S.Z., S.U. Choi and K.R. Lee. 2004. Phytochemical constituents of the Aerial parts from Solidago virga-aurea var. gigantea Miq. Arch. Pharm. Res. 27:164-168. crossref(new window)

Drel, V.R., P. Patcher, I. Vareniuk, I. Pavlov, V.V. Lyzogulbov, J.T. Grovez and I.G. Obrosova. 2007. A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice. Eup. J. Pharmacol. 569:48-58. crossref(new window)

Haenen, G.R., J.B. Paquay, R.E. Korthouwer and A. Bast. 1997. Peroxynitrite scavenging by flavonoids. Biochem. Biophys. Res. Commun. 236:591-593. crossref(new window)

Hotta, M., K. Ogata, A. Nitta, K. Hosokawa, M. Yanagi and K. Yamazaki. 1989. Useful Plants of the World. Heibonsha, Tokyo, Japan. pp. 125-127 (in Japanese).

Hsu, C.L., S.L. Huang and G.C. Yen. 2006. Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity. Agric. Food Chem. 54(12):4191-4197. crossref(new window)

Hur, J.Y., Y. Soh, B.H. Kim, K. Kang, N.W. Sohn, H.C. Kim, H.C. Kwon, K.R. Lee and S.Y. Kim. 2001. Neuroprotective and neurotrophic effects of quinic acids from Aster scaber in PC12 cells. Biol. Pharm. Bull. 24(8):921-924. crossref(new window)

Jeong, D.M., H.A. Jung and J.S. Choi. 2008. Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. Arch. Pharm. Res. 31(1):28-33. crossref(new window)

Kim, K.H., K.H. Lee, S.U. Choi, Y.H. Kim and K.R. Lee, 2008. Terpene and phenolic constituents of Lactuca indica L. Arch. Pharm. Res. 31(8):983-988. crossref(new window)

Kim, K.H., Y.H. Kim and K.R. Lee. 2007. Isolation of quinic acid derivatives and flavonoids from the aerial parts of Lactuca indica L. and their hepatoprotective activity in vitro. Bioorg. Med. Chem. Lett. 17(24):6739- 6743. crossref(new window)

Kooy, N.W., J.A. Royall, H. Ischiropoulos and J.S. Beckman. 1994. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic. Biol. Med. 16(2):149-156. crossref(new window)

Korda, M., R. Kubant, S. Patton and T. Malinski. 2008. Leptin-induced endothelial dysfunction in obesity. Am. J. Physiol. Heart Circ. Physiol. 295(4):1514-1521. crossref(new window)

Kwon, H.C., C.M. Jung, C.G. Shin, J.K. Lee, S.U. Choi, S.Y. Kim and K.R. Lee. 2000. A new caffeoyl quinic acid from Aster scaber and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. Chem. Pharm. Bull. 48(11):1796-1798. crossref(new window)

Lee, W.C. 1996. Coloured Standard Illustrations of Korean Plants. Academy Publishing Co., Seoul, Korea. p. 350 (in Korean).

Lei, C. and Y.H. Kang. 2014. Antioxidant activities of Agrimonia pilosa Ledeb: In vitro comparative activities of different fractions. Korean J. Plant Res. 27(6):642-649. crossref(new window)

Olmos, A., R.M. Giner, M.C. Recio, J.L. Rios, R. Gil-Benso and S. Manez. 2008. Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species. Arch. Biochem. Biophys. 475:66-71. crossref(new window)

Park, H.J. 2010. Chemistry and pharmacological action of caffeoylquinic acid derivatives and pharmaceutical utilization of Chwinamul (Korean mountainous vegetable). Arch. Pharm. Res. 33(11):1703-1720. crossref(new window)

Pacher, P., I.G. Obrosova, J.G. Mabley and C. Szabo. 2005. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Curr. Med. Chem. 12(3):267-275. crossref(new window)

Radi, R., J.S. Beckman, K.M. Bush and B.A. Freeman. 1991. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266(7):4244-4250.

Song, J.T., M.K. Park and Y.C. Jung. 1974. Hangook Jawon Shikmul Dogam. Gookchekmunwhasa, Seoul, Korea. p. 742 (in Korean).

Zhao, Y., J. Zhao. X.P. Li, C.X. Zhou, H.D. Sun, X.J Hao and P.G. Xiao. 2006. Advances in caffeoylquinic acid research. Zhonguo Zhongyao Zazhi 31(11):869-874 (in Chinese).