Advanced SearchSearch Tips
Anti-melanogenesis and Anti-wrinkle Properties of Korean Native Dendrobium speciosum Ethanol Extract
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Plant Resources
  • Volume 29, Issue 2,  2016, pp.155-162
  • Publisher : The Plant Resources Society of Korea
  • DOI : 10.7732/kjpr.2016.29.2.155
 Title & Authors
Anti-melanogenesis and Anti-wrinkle Properties of Korean Native Dendrobium speciosum Ethanol Extract
Sim, Mi-Ok; Lee, Hyo-Eun; Jang, Ji-Hun; Jung, Ho-Kyung; Kim, Tae-Muk; Kim, Min-Suk; Jung, Won Seok;
  PDF(new window)
Melanin is produced by melanocytes of the melanoepidermic unit and other cell types. These cells secrete and distribute the melanin pigment, which provides protection from ultraviolet radiation. In this study, the inhibitory activity against tyrosinase and melanin biosynthesis in B16F10 melanoma cells and anti-wrinkling effects on human dermal fibroblasts of Dendrobium speciosum ethanol extract were investigated. The Dendrobium speciosum extract inhibited melanin biosynthesis and tyrosinase activity in a dose-dependent manner in comparison with an untreated control group. Treatment with the Dendrobium speciosum extract suppressed α-MSH-stimulated melanogenesis in B16F10 cells and the dendrite outgrowth of melanocyte/melanoma cells. The α-MSH-induced mRNA expression of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2) and microphthalmia-associated transcription factor (MITF) was significantly attenuated in a concentration-dependent manner by Dendrobium speciosum treatment. In addition, Dendrobium speciosum treatment increased production of type I procollagen synthesis in human dermal fibroblasts. Dendrobium speciosum ethanol extract exhibited a potent inhibitory effect on melanin biosynthesis, tyrosinase activity and increased procollagen synthesis. These results indicate that Dendrobium speciosum shows promise as an ingredient in cosmeceutical products due to its whitening and anti-wrinkle effects.
Dendrobium speciosum;Melanin;Tyrosinase;Whiteni;
 Cited by
Ahn, J.J., T.Y. Hwang and H.S. Kim. 2015. Study on the physiological activities of Cleyera japonica extract. Korean J. Plant Res. 28:153-157 (in Korean). crossref(new window)

Ando, H.Y., M. Niki, K. Ito, M.S. Akiyama, D.B. Matsui, M. Yarosh and M. Ichihashi. 2012. Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion. J. Invest. Dermatol. 132:1222-1229. crossref(new window)

Bentley, N.J., T. Eisen and C.R. Goding. 1994. Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol. Cell Biol. 14:7996-8006. crossref(new window)

Berneburg, M., H. Plettenberg and J. Krutmann. 2000. Photoaging of human skin. Photodermatol. Photoimmunol. Photomed. 16:239-244. crossref(new window)

Chun, H.J., W.H. Choi, S.H. Baek and W.H. Woo. 2002. Effect of quercetin on melanogenesis in melan-a melanocyte cells. Korean J. Pharmacogn. 33:245-251 (in Korean).

Dumont, S., L. Cattuzzato, G. Trouvé, N. Chevrot and C. Stoltz. 2010. Two new lipoaminaocids with complementary modes of action: new prospects to fight out against skin aging. Int. J. Cosmet. Sci. 32:9-27. crossref(new window)

Fisher, G.J., H.S. Talwar, J. Lin and J.J. Voorhees. 1999. Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid. Photochem. Photobiol. 69:154-157. crossref(new window)

Hemesath, T.J., E.R. Price, C. Takemoto, T. Badalian and D.E. Fisher. 1998. MAP kinase links the transcription factor microphthalmia to C-Kit signalling in melanocytes. Nature 391:298-301. crossref(new window)

Jung, H.K., J.H. Jang, J.H. Ko, B.M. Kang, J.H. Yeo, J.H. Cho, H.W. Cho, C.G. Bean, S.C. Kim and W.S. Jung. 2014. Whitening and anti-wrinkle effects of Korean native Dendrobium moniliforme methanol extract. Korean J. Medicinal Crop. Sci. 22:331-338 (in Korean). crossref(new window)

Kim, N.Y., D.S. Park and H.Y. Lee. 2015. Effect of anti-skin wrinkle and antioxidant of Agastache rugosa Kentz through fermentation process of the lactic acid. Korean J. Medicinal Crop. Sci. 23:37-42 (in Korean). crossref(new window)

Kim, T.H., M.J. Kim, J.M. Baek, T.W. Kim, D.J. Kim, J.H. Park and M. Choe. 2011. Antioxidant and whitening effects of Agrimonia pilosa Ledeb water extract. Korean J. Medicinal Crop. Sci. 19:177-184 (in Korean). crossref(new window)

Lee, S.Y., J.H. An and H.Y. Cho. 2003. Isolation and characterization of MMP-1 inhitor peptide from Crataegus pinnatifida bunge in fibroblast cell line HS68 cells. J. Korean. Soc. Appl. Biol. Chem. 46:60-65 (in Korean).

Liu, J.J. and D.E. Fisher. 2010. Lighting a path to pigmentation: mechanisms of MITF induction by UV. Pigment Cell Melanoma Res. 23:741-745. crossref(new window)

Miyamura, Y., S.G. Coelho, R. Wolber, S.A. Miller, K. Wankamatsu, B.Z. Zmudzka, S. Ito, C. Smuda, T. Passeron, W. Choi, J. Batzer, Y. Yamaguchi, J.Z. Beer and V.J. Hearing. 2007. Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Res. 20:2-13. crossref(new window)

Moretti, M., L. Cossignani, F. Messina, L. Dominici, M. Villarini, M. Curini and M.C. Marcotullio. 2013. Antigenotoxic effect, composition and antioxidant activity of Dendrobium speciosum. Food Chem. 140:660-665. crossref(new window)

Olivares, C. and F. Solano. 2009. New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins. Pigment Cell Melanoma Res. 22:750-760. crossref(new window)

Park, E.Y., S.H. Lee and Y.C. Kim. 2013. Whitening efficacy of water-soluble extracts from Prunophora salicina’s (Daeseokjosaeng, Purplekin, Formosa) Peel. J. Invest. Cosmetology 9:27-32 (in Korean). crossref(new window)

Park, H.Y., M. Kosmadaki, M. Yaar and B.A. Gilchrest. 2009. Cellular mechanisms regulating human melanogenesis. Cell. Mol. Life Sci. 66:1493-1506. crossref(new window)

Schiaffino, M.V. 2010. Signaling pathways in melanosome biogenesis and pathology. Int. J. Biochem. Cell Biol. 42:1094-1104. crossref(new window)

Seiberg, M. 2001. Keratinocyte-melanocyte interactions during melanosome transfer. Pigment Cell Res. 14:236-242. crossref(new window)

Seo, S.Y., V.K. Sharma and N. Sharma. 2003. Mushroom tyrosinase: recent prospects. J. Agric. Food Chem. 51:2837-2853. crossref(new window)

Wu, M., T.J. Hemesath, C.M. Takemoto, M.A. Horstmann, A.G. Wells, E.R. Price, D.Z. Fisher and D.E. Fisher. 2000. C-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev. 14:301-312.

Yang, S.Y. and H.O. Boo. 2013. Phenolic compounds, antimicrobial effects and tyrosinase inhibition activities of cucumber grown greenhouse according to cultivars and growth stages. Korean J. Plant Res. 26:645-651 (in Korean). crossref(new window)

Yang, Y.M., Y.O. Son, S.A. Lee, Y.M. Jeon and J.C. Lee. 2011. Quercetin inhibits α-MSH-stimulated melanogenesis in B16F10 melanoma cells. Phytother. Res. 25:1166-1173. crossref(new window)

Yoo, J.M., Y.J. Kang, H.B. Pyo, E.S. Choung, S.Y. Park, J.H. Choi, G.J. Han, C.H. Lee and T.J. Kim. 2010. Anti-wrinkle effects of Korean rice wine cake on human fibroblast. J. Life Sci. 20: 1838-1843 (in Korean). crossref(new window)

Yoon, M.Y. and Y.S. Han. 2014. Effect of anti-oxidant activity and the skin whitening action on Plantago asiatica L. root extract. KSBB J. 29:199-204 (in Korean). crossref(new window)