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Degradation Behaviors of Poly(l-lactide) using Model Systems
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 Title & Authors
Degradation Behaviors of Poly(l-lactide) using Model Systems
Min Seong-Kee; Moon Myong-Jun; Lee Won-Ki;
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The hydrolytic kinetics of biodegradable poly(l-lactide) (PLLA) have been studied by using two model systems, solution-grown single crystal (SC) and Langmuir monolayer techniques, for elucidating the mechanism for both alkaline and enzymatic degradations. The present study investigated the parameters such as degradation medium and time. The Langmuir mono layers of PLLA showed faster rates of hydrolysis when they were exposed to a basic subphase rather than they did when exposed to neutral subphase. Both degradation mediums had moderate concentrations to show a maximized activity, depending on their sizes. An alkaline degradation of SCs of PLLA showed the decrease of molecular weight of the remained crystals due to the erosion of chain-folding surface. However, the enzymatic degradation of SCs of PLLA occurred in the crystal edges thus the molecular weight of remained crystals was not changed. This behavior might be attributed to the size of enzymes which is much larger than that of alkaline ions; that is, the enzymes need larger contact area with monolayers to be activated.
Poly(l-lactide);Langmuir monolayer;Solution-grown crystals;Degradation;
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입체화학을 이용한 생분해성 고분자의 분해속도에 관한 연구,박찬영;최용해;이원기;

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