Advanced SearchSearch Tips
Risk Assessment of Nitrogen Dioxide for Hematological and Biochemical Parameter in Mice
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Risk Assessment of Nitrogen Dioxide for Hematological and Biochemical Parameter in Mice
Jeong, Seong-Wook; Han, Yong-Soo; Park, Heung-Jai;
  PDF(new window)
In this study, we evaluated the property change and relationship between hematological and biochemical parameters in exposure group and control group by multiple inhalation exposure, of . In case of leukocyte, change of hematological property increased significantly in statistics (p<0.05) in mice experiment. in case of hematocrit of exposure group, it was of decreased significantly in statistics. the tendency of hemoglobin and hematocrit was similar to all for three case. in case of methmoglobin that of the exposure group in mice experiment was meaning increased(p<0.05). For the influence in biochemical property, total protein and triglyceride was decreased but not significant in statistics, albumin was decreased in the exposure group in the animal experiments, blood urea nitrogen and creatinine increased significantly in statistics in the animal experiments. uric acid and lactate dehydrogenase in serum increased significantly in the exposure group. We have to evaluate risk assessment for the of indoor air pollutant in low concentration and long time.
Nitrogen dioxide();Hematological parameter;Biochemical parameter;Inhalation exposure;Risk assessment of Nitrogen Dioxide;
 Cited by
William N. R., 1998, Environmental and Occupational disease ; Nitrogen Dioxide/Nitric oxide. 3rd. ed., Lippincott Raven, 617-629pp

Krishna M. T., Holgate S. T., 1999, Inflammatory mechanisms underlying potentiation of effects of inhaled aeroallergens in response to nitrogen dioxide in allergic airway disease, Clinical and Experimental Allergy, 29, 150-154 crossref(new window)

Farrar D., Dingle P., Tan R., 2001, Exposure to nitrogen dioxide in Buses, Taxis and Bicycles in perth, Western Australia. Bull. Environ. Contam. Toxicol., 66, 433-438 crossref(new window)

Rebecca L. P., Wendy M. B., Nicholas H. H., 2001, Nitrogen dioxide Induces death in lung Epithelial cells in a Density Dependent Manner. Am. J. Respir. Cell Mol. Biol., 24, 583-590 crossref(new window)

Susanne B., Joleen M. S., 1999, Effect of nitrogen dioxide on Respiratory Vial Infection in Airway Epithelial Cells. Environ. Research Section A, 81, 159-166 crossref(new window)

Rernijin B., Fischer P., Brunekreef B., 1985, Indoor air pollution and its effect on pulmonary function of adult non smoking women : I. Exposure estimates for nitrogen dioxide and passive smoking, Int. J. Epidemil., 14, 215-220 crossref(new window)

Ana O. M., Amaya A. D., 2000, nitric oxide reactivity and mechanism involved in its biological effects, Pharmacological Research, 42(5), 421-427 crossref(new window)

Kelly F. J., Blomberg A., Frew A., Holgate S.T., Sandstrom T., 1996,Antioxidant kinetic in lung lavage fluid following exposure of humans to nitrogen dioxide. Am. J. Respir. Crit. Care Med., 154, 1700-1705 crossref(new window)

양용석, 변대훈, 김성미, 2001, 최신임상혈액학, 대학서림, 27-28pp

Solomon C., Christian D. L., Chen L. L., Welch B. S., Kieinman M. T., Dunham E., Erle D. J., Balmes J. R., 2000, Effect of serialday exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. Eur. Respir. J, 15(5), 922-928 crossref(new window)

Rutowski J., Moszczynski P., Dobrowolski J,W., 1998. The effects of occupational exposure to nitrogen dioxide$NO_{2}$) on the immunological parameters in workers. Med. Pr., 49(4), 341-35

이귀녕, 이종순. 1990, 임상병리파일, 의학문화사, 82-96pp

Posin C., Buckley R. D., Chark K., Hackney J, D., Jones M. P., Patterson J, V., 1978. nitrogen dioxide inhalation and human blood biochemistry. Arch. Environ. Health., 33(6), 318-324 crossref(new window)

Mark W., Joseph boscia F., Norbert J, R., Jr., 2002, Nitrogen dioxide exposure: effects on airway and blood cells. Am. J. Physiol. Lung cell Physiol., 282, 155-165

William J, M., Michael T. K., Deepal K. B., Robert F. P., 2001, Respiratory Tract Responses to Repeated Inhalation of an Oxidant and Acid Gas-Particle Air Pollutant Mixture, Toxicological science, 61, 331-34l crossref(new window)

Frampton M. W., Finkelstein J. N., 1989.Effects of nitrogen dioxide exposure on bronc-hoalveolar lavage proteins in humans, Am. J. Respir. Cell Mol. Biol.,1(6), 499-505 crossref(new window)

Giroux M., Ferrieres J., 1998, Serum nitrites and creatinine in workers exposed to atmospheric nitrogen oxides and ammonia, The science of the total environment, 217, 265-269 crossref(new window)