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Effect of Ore Minerals on the Healing of Full-Thickness Skin Injury Model of Rat
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 Title & Authors
Effect of Ore Minerals on the Healing of Full-Thickness Skin Injury Model of Rat
Choi, Kwang-Man; Lee, Chang-Won; Lee, Mi-Young;
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The oriental ore minerals, which mainly consisted of talc, actinolite, sericite, and halloysite were developed, and then used to examine the healing effect on the skin wound in rats. Full-thickness square wounds were formed on the backs of rats after the hairs on the dorsal surface were shaved. The ore minerals were applied to examine the healing effect from day 0 to 15 after wounding. Notable wound healings in terms of congestion around the wound, wound contraction and epithelialization were found in ore mineral-treated groups. Moreover, microscopic results revealed the formation of epithelial layer, hair follicles and progressive angiogenesis in ore mineral-treated groups, while complete epithelial layer could not be found in the control. These results suggest that ore minerals from Korean indigenous ores may have wound healing effect on the skin injury in rats.
Ore minerals;Skin wound;Wound healing;Rats;
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Celso de Sousa F. G., Joao Baptista P. S., 2007, Minerals and clay minerals in medical geology, Applied Clay Sci., 36, 4-21 crossref(new window)

Viseras C., Aguzzi C., Cerezo P., Lopez-Galindo A., 2007, Uses of clay minerals in semisolid health care and therapeutic products, Applied Clay Sci., 36, 37- 50 crossref(new window)

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Han D. O., Kim G. H., Choi Y. B., Shim I. S., Lee H. J., 2005, Healing effects of astragali radix extracts on experimental open wound in rat, Oriental Physiology & Pathology, 19(1), 92

Probst C. W., 1993, Wound healing and specific tissue regeneration. In: Textbook of small animal surgery, 2nd ed, Philadelphia:WB Saunders, 53-63

Qi S. H., Liu P., Xie J. L., Shu B., Xu Y. B., 2008, Experimental study on repairing of nude mice skin defects with composite skin consisting of xenogeneic dermis and epidermal stem cells and hair follicle dermal papilla cells, Burns, 34(3), 385-392 crossref(new window)

Adam J., Singer M. D., Richard A. F., Clark M. D., 1999, Cutaneous wound healing, N. Engl. J. Med., 341(10), 738-746 crossref(new window)

Coulombe P. A., 2003, Wound epithelialization: accelerating the pace of discovery, J. Invest. Dermatol, 121(2), 219-230 crossref(new window)

Martin P., 1997, Wound healing-aiming for perfect skin regeneration, Science, 276(5309), 75-81 crossref(new window)

Iseri S. O., Gedik I. E., Erzik C., Uslu B., Arbak S., 2008, Oxytocin ameliorates skin damage and oxidant gastric injury in rats with thermal trauma, Burns, 34(3), 361-369 crossref(new window)

Hosgood G., 2003, Wound repair and specific tissue response to injury. In: Textbook of small animal surgery, 3rd ed, Philadelphia: Saunders, 66-86

Goldman R., 2004, Growth factors and chronic wound healing: past, present, and future, Adv. Skin Wound Care, 17(1), 24-35 crossref(new window)

Lauren M., David S., Richard A. F., Clark M. D., 2007, Growth factor binding to the pericellular matrix and its importance in tissue engineering, Adv. Drug Deliv. Rev., 59(13), 1366-1381 crossref(new window)

Joeng S. I., Kang S. S., Cho S. K., Choi S. H., 2000, Effect of propolis on healing of full-thickness skin wound in rabbits, Korean J. Vet. Clin. Med., 17(1), 62-69

Cass D. L., Sylvester K. G., Yang E. Y., Crombleholme T. M., Adzick N. S., 1997, Myofibroblast persistence in fetal sheep wounds is associated with scar formation, J. Pediatr. Surg., 32(7), 1017-1021 crossref(new window)

Estes J. M., Vande Berg J. S., Adzick N. S., MacGillivray T. E., Desmouliere A., 1994, Phenotypic and functional features of myofibroblasts in sheep fetal wounds, Differentiation, 56(3), 173-181 crossref(new window)

Liu M., Warn J. D., Fan Q., Smith P. G., 1999, Relationships between nerves and myofibroblasts during cutaneous wound healing in the developing rat, Cell Tissue Res., 297(3), 423-433 crossref(new window)

Nedelec B., Dodd C. M., Scott P. G., Ghahary A., Tredget E. E., 1998, Effect of interferon-alpha2b on guinea pig wound closure and the expression of cytoskeletal proteins in vivo, Wound Repair Regen., 6(3), 202-212 crossref(new window)

Swaim S. F., Henderson R. A., 1998, Small animal wound management, 27(2), 148-158

Myers S. R., Leigh I. M., Navsaria H., 2007, Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade, Wound Repair Regen., 15(5), 693-701 crossref(new window)

Schilling J. A., 1968, Wound healing, Physiol. Rev., 48(2), 374-423 crossref(new window)

Page R. C., Davies P., Allison A. C., 1974, Pathogenesis of the chronic inflammatory lesion induced by group a streptococcal cell walls, Lab. Invest., 30(5), 568- 581

Saygun I., Karacay S., Serdar M., Ural A. U., Sencimen M., 2008, Effects of laser irradiation on the release of basic fibroblast growth factor (bFGF), insulin like growth factor-1 (IGF-1), and receptor of IGF-1 (IGFBP3) from gingival fibroblasts, Lasers in Medical Science, 23(2), 211-215 crossref(new window)