Advanced SearchSearch Tips
Detection Characteristics of Blood Lipid Lower Agents (BLLAs) in Nakdong River Basin
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Detection Characteristics of Blood Lipid Lower Agents (BLLAs) in Nakdong River Basin
Son, Hee-Jong; Seo, Chang-Dong; Yeom, Hoon-Sik; Song, Mi-Jung; Kim, Kyung-A;
  PDF(new window)
The aims of this study were to investigate and confirm the occurrence and distribution patterns of blood lipid lower agents (BLLAs) in Nakdong river basin (mainstream and its tributaries). 4 (atorvastatin, lovastatin, mevastatin and simvastatin) out of 5 statins and 2 (clofibric acid and zemfibrozil) out of 3 fibrates were detected in 29 sampling sites and simvastatin (>50%) was predominant compound followed by atorvastatin, lovastatin and clofibric acid. The total concentration levels of BLLAs on April, August and November 2009 in surface water samples ranged from ND~25.7 ng/L, ND~18.8 and ND to 38.8 ng/L, respectively. The highest concentration level of BLLAs in the mainstream and tributaries in Nakdong river were Goryeong and Jincheon-cheon, respectively. The sewage treatment plants (STPs) along the river affect the BLLAs levels in river and the BLLAs levels decreased with downstream because of dilution effects.
Blood lipid lower agents;Statin class;Fibrate class;Main stream;Tributary;Nakdong river basin;
 Cited by
Bendz, D., Paxeus, N. A., Ginn, T. R., Loge, F. J., 2005, Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Hoje River in Sweden, J. Hazard. Mater., 122, 195-204. crossref(new window)

Dorne, J. L. C., Ragas, A. M., Frampton, G. K., Spurgeon, D. S., Lewis, D. F., 2007, Trends in human risk assessment of pharmaceuticals, Anal. Bioanal. Chem., 387, 1167-1172. crossref(new window)

Farre, M., Ferrer, I., Ginebreda, A., Figueras, M., Olivella, L., Tirapu, L., Vilanova, M., Barcelo, D., 2001, Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri, J. Chromatogr. A, 938, 187-197. crossref(new window)

Fent, K., Weston, A. A., Caminada, D., 2006, Ecotoxicology of human pharmaceuticals, Aquat. Toxicol., 76, 122-159. crossref(new window)

Halling-Sorensen, B., Nielson, S. N., Lanzky, P. E., Ingerslev, L. F., 1998, Occurrence, fate and effects of pharmaceutical substances in the environment-a review, Chemosphere, 36(2), 357-393. crossref(new window)

Hernando, M. D., Agüera, A., Fernandez-Alba, A. R., 2007, LC-MS analysis and environmental risk of lipid regulators, Anal. Bioanal. Chem., 387(4), 1269-1285. crossref(new window)

Martin, J., Buchberger, W., Alonso, E., Himmelsbach, M., Aparicio, I., 2011, Comparison of different extraction methods for the determination of statin drugs in wastewater and river water by HPLC/QTOF- MS, Talanta, 85, 607-615. crossref(new window)

Mimeault, C., Woodhouse, A. J., Miao, X. S., Metcalfe, C. D., Moon, T. W., Trudeau, V. L., 2005, The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus, Aquat. Toxicol., 73, 44-54. crossref(new window)

Moldovan, Z., 2006, Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania, Chemosphere, 64, 1808-1817. crossref(new window)

Mompelat, S., Le Bot, B., Thomas, O., 2009, Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water, Environ. Int., 35, 803-814. crossref(new window)

Pal, A., Gin, K. Y. H., Lin, A. Y. C., Reinhard, M., 2010, Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects, Sci. Total Environ., 408, 6062-6069. crossref(new window)

Seo, C. D., Son, H. J., Lee, I. S., Oh, J. E., 2010, Detection of synthetic musk compounds (SMCs) in Nakdong River basin, J. Kor. Soc. Environ. Eng., 32(6), 615-624.

Son, H. J., Yeom, H. S., Jung, J. M., Jang, S. H., Kim, H. S., 2012, Caffeine and carbamazepine: detection in Nakdong River basin and behavior under drinking water treatment processes, J. Environ. Sci. Intl., 21(7), 837-843. crossref(new window)

Son, H. J., Hwang, Y. D., Yoom, H. S., Choi, J. T., Kwon, K. W., 2013a, Detection of perfluorinated compounds (PFCs) in Nakdong River basin, J. Kor. Soc. Environ. Eng., 35(2), 84-93.

Son, H. J., Yoom, H. S., Jung, J. M., Jang, S. H., 2013b, Application of on-line SPE-LC/MSD to measure perfluorinated compounds (PFCs) in water, J. Kor. Soc. Environ. Eng., 35(2), 75-83. crossref(new window)

Stumpf, M., Ternes, T. A., Wilken, R. D., Rodrigues, S. V., Baumann, W., 1999, Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil, Sci. Total Environ., 225, 135-141. crossref(new window)

Ternes, T, A., 1998, Occurrence of drug in German sewage treatment plants and rivers, Water Res., 32(11), 3245-3260. crossref(new window)

Westerhoff, P., Yoon, Y., Snyder, S., Wert, E., 2005, Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes, Environ. Sci. Technol., 39, 6649-6663. crossref(new window)

Yamamoto, H., Nakamura, Y., Nakamura, Y., Kitani, C., Imari, T., Sekizawa, J., 2007, Initial ecological risk assessment of eight selected human pharmaceuticals in Japan, Environ. Sci., 14, 177-193.