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Effects of Schizandra Cchinensis Fruit Extract on the Hyperglycemia and Hyperlipemia in Streptozotocin-induced Diabetic Rats
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  • Journal title : KSBB Journal
  • Volume 26, Issue 2,  2011, pp.126-130
  • Publisher : Korean Society for Biotechnology and Bioengineering
  • DOI : 10.7841/ksbbj.2011.26.2.126
 Title & Authors
Effects of Schizandra Cchinensis Fruit Extract on the Hyperglycemia and Hyperlipemia in Streptozotocin-induced Diabetic Rats
Chae, Hee-Jun; Lee, In-Soon; Moon, Hae-Yeon;
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 Abstract
To investigate the antihyperglycemic and antihyperlipemic effect of 80% ethanol extract of Schizandra Chinensis fruit, we induced diabetes in the rats with streptozotocin (STZ) and administered schizandra extract or Acarbose to diabetic rats for 21 days by oral administration. Consequently, the groups treated using schizandra extract decreased blood glucose levels more 39% than no treatment group and the case of Acarbose group was decreased it about 21%. The concentration of cholesterol, triglyceride and LDL-C in blood was also decreased while treating schizandra extract, on the other hand, HDL-C concentration was significantly increased it about 26%. Those results induced that anti-atherogenic index (AAI) in blood was improved more than 82% level like normal condition, especially in treatment of schizandra extract 100 mg. The lipid profiled in feces was likewise showed apparent tendency to decrease and food efficiency ratio of diabetic rats was became higher for treatment with schizandra extract, but Acarbose group had low efficiency in compared with the result of glucose level and lipid profile in blood. As a result, schizandra extract is regard a good medicine for diabetes due to improve physical constitution, blood glucose and lipid level caused hyperglycemia and suggest that schizandra extract has real effects on the diabetes complication as atherosclerosis, coronary heart disease, high blood pressure.
 Keywords
Schizandra Chinensis;hyperglycemia;Diabetes;hyperlipemia;anti-atherogenic index (AAI);
 Language
Korean
 Cited by
1.
백출이 streptozotocin 유발 당뇨흰쥐에서 췌장 및 신장에 미치는 영향,한윤경;박용기;

대한본초학회지, 2011. vol.26. 4, pp.23-30 crossref(new window)
2.
고지방·고탄수화물 식이와 Streptozotocin-유도 당뇨병 흰쥐에서 삼릉추출물의 개선효능 연구,강안나;강석용;송미영;박용기;

한방비만학회지, 2016. vol.16. 2, pp.92-100 crossref(new window)
3.
오미자(五味子) 추출물의 인간 전립선암 세포주 PC-3에 대한 성장 억제 효과,문정민;석가형;조수인;

대한본초학회지, 2012. vol.27. 4, pp.17-23 crossref(new window)
4.
지골피, 산수유의 streptozotocin 유발 당뇨흰쥐에서의 효과 비교 연구,한윤경;박용기;

대한본초학회지, 2013. vol.28. 6, pp.71-77 crossref(new window)
5.
창출이 제 2형 당뇨병 흰쥐에 미치는 영향,이대훈;한재민;양웅모;

대한한의학회지, 2015. vol.36. 1, pp.75-85 crossref(new window)
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Effects of Spagranii Rhizoma Extract on High Fat·High Sucrose Diet and Streptozotocin Administration-Induced Diabetic Rats, Journal of Korean Medicine for Obesity Research, 2016, 16, 2, 92  crossref(new windwow)
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The effects of Koidz. on type 2 diabetic rats, Journal of Korean Medicine, 2015, 36, 1, 75  crossref(new windwow)
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