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The Microsponge Delivery System of Itraconazole: Preparation, Characterization and Release Studies
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  • Journal title : KSBB Journal
  • Volume 26, Issue 3,  2011, pp.217-222
  • Publisher : Korean Society for Biotechnology and Bioengineering
  • DOI : 10.7841/ksbbj.2011.26.3.217
 Title & Authors
The Microsponge Delivery System of Itraconazole: Preparation, Characterization and Release Studies
Cho, Young-Ho; Lee, Jong-Hwa; Kim, Hak-Hyung; Lee, Gye-Won;
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 Abstract
Itraconazole is a triazole antifungal agent to inhibit most fungal pathogens. To improve the oral absorption and dissolution of poorly water-soluble itraconazole, microsponge system composed of E100 and polyvinyl alcohol(PVA) formulated by quasi-emulsion solvent diffusion method, and its physicochemical properties and pharmacokinetic parameters of itraconazole were studied. The microsponge of itraconazole were discrete free flowing micro sized particles with perforated orange peel like morphology as visualized by scanning electron microscope (SEM). Results showed that the drug loading efficiency, production yield, and particle size of itraconazole microsponge were affected by drug to polymer ratio, the volume of internal phase containing methylene chloride, stirring rate and the concentration of PVA used. Also, the results showed that the dissolution rate of itraconazole from the microsponges was affected by drug to polymer ratio. In other words, the release rate of itraconazole from microsponges was increased from at least 27.43% to 64.72% after 2 h. The kinetics of dissolution mechanism showed that the dissolution data followed Korsmeyer-Peppas model. Therefore, these results suggest that microsponge system can be useful for the oral delivery of itraconazole by manipulating the release profile.
 Keywords
microsponge;itraconazole; E 100;polymer;dissolution rate;
 Language
Korean
 Cited by
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