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Evaluation of Nattokinase for Antithrombotic Effect and Pharmacological Efficacy by a Biological Test and Clinical Trial
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  • Journal title : KSBB Journal
  • Volume 26, Issue 5,  2011, pp.393-399
  • Publisher : Korean Society for Biotechnology and Bioengineering
  • DOI : 10.7841/ksbbj.2011.26.5.393
 Title & Authors
Evaluation of Nattokinase for Antithrombotic Effect and Pharmacological Efficacy by a Biological Test and Clinical Trial
Kim, Jae-Bum; Yoo, Chul-Bae; Shin, Hyun-Man; Jung, Joon-Ki; Jang, Hyung-Wook;
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Bacillus subtilis natto producing high level of a fibrinolytic enzyme was selected and Ultra Nattokinase was manufactured by fermentation and purification. It was performed the evaluation of the antithrombotic effect of Ultra Nattokinase (20,000 FU/g) with rat blood plasma. The maximum aggregation (inhibition ratio) was 71% (0%), 69% (2.8%), 62% (12.7%), 16% (77.5%) and 9% (87.3%), respectively, in the order of 0, 5, 10, 50 and 100 mg/mL of Ultra Nattokinase solutions. Ultra Nattokinase had antithrombotic effect, which was associated with the suppression of collagen-induced platelet aggregation. Ultra Nattokinase in the topic of the FDP (fibrinogen degradation products) in blood coagulation tests showed a significant increasing trend. And based on the daily record of meal 39 people of ITT (what ?) group consisted with 19 people of NP (what ?) group and 20 people of PN (what ?) group except four people, two people who took vitamin K affecting the experiment and two people who took alcohol, finding to be taken Ultra Nattokinase showed an increase in the FDP value after four weeks. In addition, FDP value of 41 people of ITT group except two people having metabolic syndrome was increased by Ultra Nattokinase.
Bacillus subtilis natto;Ultra Nattokinase;Antithrombotic effect;Pharmacological efficacy;FDP;
 Cited by
Bacillus subtilis Natto가 생산하는 Nattokinase의 항혈전 및 피브린 용해능 효능평가,이다령;홍성유;장양수;장형욱;맹창재;유철배;백대헌;

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