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Development of Bioavailability Enhancement System for the Skin Permeation Promotion of Psolarea corylifolia Extract
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  • Journal title : KSBB Journal
  • Volume 26, Issue 6,  2011, pp.505-512
  • Publisher : Korean Society for Biotechnology and Bioengineering
  • DOI : 10.7841/ksbbj.2011.26.6.505
 Title & Authors
Development of Bioavailability Enhancement System for the Skin Permeation Promotion of Psolarea corylifolia Extract
Cho, Young-Ho; Ahn, Ghe-Whan; Yang, Seung-Won; Cho, Kwan-Hyun; Kim, Sang-Won; Baek, Ki-Myoung; Lee, Gye-Won;
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Psolarea corylifolia extract that contains bakuchiol is known to have anti-microbial, anti-inflammatory and anti-scarring effects. In this study, a vesicles such as liposome, niosome, and transfersome were produced to encapsulate P. corylifolia extract and measured their stability and physiochemical property. The skin permeation and partitioning of P. corylifolia extract in the vesicles were elucidated in nude mouse skin by using Franz diffusion cells after topical application for 24 h. After storage at 25, 40, , and light, the stability of bakuchiol incorporated into the vesicles was maintained for 30 days. The optimal concentration of P. corylifolia extract entrapped into the vesicles was found to be 5~10%. From the physicochemical studies, after storage at 4, 25, and , the viscosity and particle size of the vesicles remained in 30~80 cP and the nanosize range for 6 months, respectively. From the permeation experiments, niosome showed a higher amount of bakuchiol permeated through the mouse skin compared to liposome and transfersome after 24 h. From these results, niosome and transfersome could be a good bioavailability enhancement system (BAES) for P. corylifolia extract to improve the skin permeation and stability.
Psolarea corylifolia extract;bioavailability enhancement system;skin permeation;skin deposition;
 Cited by
Oh, S. J. (2008) BAES. Trademark 0115076.

Barry, B. W. (2001) Novel mechanism and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci. 14: 101-114. crossref(new window)

Kim, S. (1993) Liposomes as carriers of cancer chemotherapy: current status and future prospects. Drugs. 46: 618-638. crossref(new window)

Booser, D. and G. Hortobagyi (1994) Anthracycline antibiotics in cancer therapy: focus on drug resistance. Drugs. 47: 223-258. crossref(new window)

Barber, R. and P. Shek (1993) Pharmaceutical Particulate Carriers. pp. 1-20. In: A. Rolland (eds.). Liposomes as a topical acular drug delivery system. Marcel Dekker, NY, USA.

Wong, M. and T. Thompson (1982) Aggregation of dipamitoylphosphatidylcholine vesicles. Biochemistry. 21: 4133-4139. crossref(new window)

Vora, B., A. J. Khopade, and N. K. Jain (1998) Proniosome based transdermal delivery of levonorgestrel for effective contraception. J. Control. Rel. 54: 149-165. crossref(new window)

Yoshioka, T., B. Sternberg, and A. T. Florence (1994) Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) a sorbitan triester (Span 85). Int. J. Pharm. 105: 1-6. crossref(new window)

Liu, T., R. Guo, W. Hua, and J. Qui (2007) Structure of hemoglobin in PEG 6000/Tween 80/Span 80/$H_2O$ noisome system. Colloids and surface A: Physicochem. Eng. Aspects. 293: 255-261. crossref(new window)

Knepp, V. M., R. S. Hinz, F. C. Szoka, and R. H. Guy (1998) Controlled drug release from a novel liposomal delivery system. I. Investigation of transdermal potential. J. Control. Rel. 5: 211-221.

Knepp, V. M., F. C. Szoka, and R. H. Guy (1990) Controlled drug release from a novel liposomal delivery system. II. Transdermal delivery characteristics. J. Control. Rel. 12: 25-30. crossref(new window)

Fang, J. Y., C. H. Hong, W. T. Chiu, and Y. Y. Wang (2001) Effect of liposome and niosomes on skin permeation of enoxacin. Int. J. Pharm. 219: 61-72. crossref(new window)

Cevc, G. (1992) Liposome Technology. 2nd ed., pp. 1-36. In: G. Gregoriadis (eds.). Lipid Properties as a Basis for the Modelling and Design of Liposome Membranes. CRC-Press, Boca Raton, FL.

G. Cevc (1995) Handbook of Physics vol. I. pp. 441-466. In: R. Lipowsky and E. Sackmann (eds.). Material Transport Across Permeability Barriers by Means of Lipid Vesicles. Elsevier Science, NY, USA.

Kaul, R. (1976) Kinetics of the anti-staphylococcal activity of bakuchiol in vitro. Arzneimittelforschung. 26: 486-489.

Katsura, H., R. I. Tsukiyama, A. Suzuki, and M. Kobayashi (2001) In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob Agents Chemother. 45: 3009-3013. crossref(new window)

Chaudhuri, R., K. Bojanowski, and F. Marchio (2011) Retinol and retinol-like compounds in skin care. Expression Cosmetique. 227-233.

Chaudhuri, R. and F. Marchio (2011) Bakuchiol in the management of acne affected skin. Cosmetics & Toiletries. 126: 502-510.

Lee, S. J. & Kim, J. H. (1993) Emulsive cosmetic composition of micromultiple lamella small ball structure and preparation thereof. KR Patent 0115076.

So, K. S. & Park, D. L. (1993) Micromultiple sphere composition containing cosmetic component with skin activity and its preparation. KR Patent 0107609.

Han, J. W. and J. C. Lim (1999). Study on solubilization of Bunker-C by nonionic surfactans. Applied Chemistry. 3: 324-327.

Laia, C. A. T., W. Brown, M. Almgren, and S. M. B. Costa (2000) Light scattering study of water-in-oil AOT microemusions with poly(oxy)ethylene. Langumuir. 16: 465-470. crossref(new window)

Lehner, D., H. Lindner, and O. Glatter (2000) Determination of the translational and rotational diffusion coefficients of rodlike particles using depolarized dynamic light scattering. Lagumuir. 16: 1689-1695. crossref(new window)